RhoA-ROCK-IN-1 (Compound b19) is an inhibitor of RhoA/ROCK. RhoA-ROCK-IN-1 can significantly inhibit cell proliferation, migration, and invasion, while promoting cell apoptosis. RhoA-ROCK-IN-1 demonstrates remarkable anticancer activity by inhibiting the RhoA/ROCK pathway [1].
References:
[1]. Liang J, et al. Synthesis and in vitro evaluation of benzo [b] thiophene-3-carboxylic acid 1, 1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39(1): 2390911.
References:
[1]. Liang J, et al. Synthesis and in vitro evaluation of benzo [b] thiophene-3-carboxylic acid 1, 1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39(1): 2390911.