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Melanocortin (MC) Receptors

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Melanocortin receptors (MCRs) comprise a family of five, class A, G protein-coupled receptors designated MC1R-MC5R with diverse physiological roles. MCRs are found in chordates and are regarded as having evolved from a single ancestral receptor, possibly corresponding most closely to MC4R. Signaling by MCRs has primarily been observed as occurring through the stimulatory α unit Gs which activates adenylyl cyclase to produce cAMP.

The central nervous melanocortin system is involved in energy homeostasis, regulating food intake and energy expenditure. The brain melanocortin system is defined as the primary neurons that express neuropeptide ligands, and secondary neurons expressing the predominant neural melanocortin receptors (MC3R, MC4R). Mutations in the gene encoding melanocortin receptor agonists, or the genes encoding MC3R or MC4R cause obesity. The other members of the melanocortin receptor family are primarily expressed in the periphery, and are involved in regulating pigmentation (MC1R), adrenal gland function (MC2R), immune function (MC1R/MC3R), and sebaceous gland activity (MC5R).

Products Related to Melanocortin (MC) Receptors(57)

  • GC10701 structure
    GC10701JKC 363
    CAS: 436083-30-6
    Purity: >98%

    melanocortin MC4 receptor antagonist

  • GC10747 structure
    GC10747HS 024
    CAS: 212370-59-7
    Purity: >98%

    melanocortin MC4 receptor antagonist

  • GC10947 structure
    GC10947[D-Trp8]-γ-MSH
    CAS: 321351-81-9
    Purity: >98%

    [D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells.

  • GC12163 structure
    GC12163PG 106
    CAS: 944111-22-2
    Purity: >98%

    hMC3 receptor antagonist

  • GC12239 structure
    GC12239Adrenocorticotropic Hormone (ACTH) (1-39)
    CAS: 12279-41-3
    Purity: >98.00%

    Adrenocorticotropic Hormone (ACTH) (1-39) is a potent melanocortin 2 receptor (MC2R) agonist produced by the anterior pituitary gland.

  • GC12840 structure
    GC12840HS 014
    CAS: 207678-81-7
    Purity: >98%

    HS 014 is a potent and selective melanocortin MC4 receptor antagonist (K i =3.16nM).

  • GC13068 structure
    GC13068[Nle4,D-Phe7]-α-MSH
    CAS: 75921-69-6
    Purity: >99.00%

    [Nle4,D-Phe7]-α-MSH is a potent non-selective melanocortin receptor (MCR) agonist. [Nle4,D-Phe7]-α-MSH is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. [Nle4,D-Phe7]-α-MSH can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. [Nle4,D-Phe7]-α-MSH can be used for sunlight-induced skin cancers research.

  • GC13565 structure
    GC13565SHU 9119
    CAS: 168482-23-3
    Purity: >98.00%

    melanocortin MC3 and MC4 receptor antagonist

  • GC13798 structure
    GC13798ML 00253764 hydrochloride
    CAS: 1706524-94-8
    Purity: >98%

    melanocortin MC4 receptor antagonist

  • GC13806 structure
    GC13806Lys-γ3-MSH
    CAS: 156159-18-1
    Purity: >98%

    Lys-γ3-MSH is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC).

  • GC14127 structure
    GC14127MCL 0020
    CAS: 475498-26-1
    Purity: >98%

    melanocortin MC4 receptor antagonist

  • GC14374 structure
    GC14374α-MSH
    CAS: 581-05-5
    Purity: >98.00%

    Alpha-melanocyte-stimulating hormone (α-MSH) is a neuropeptide with immunomodulatory properties that is produced by post-translational processing of proproiomelanocortin (POMC).

  • GC16069 structure
    GC16069THIQ
    CAS: 312637-48-2
    Purity: >98.00%

    melanocortin 4 (MC4) receptor agonist

  • GC16276 structure
    GC16276Melanotan II
    CAS: 121062-08-6
    Purity: >99.50%

    Melanotan II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.

  • GC17002 structure
    GC17002γ1-MSH
    CAS: 72629-65-3
    Purity: >98%

    γ1-MSH is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor.

  • GC17626 structure
    GC17626PG 931
    CAS: 667430-81-1
    Purity: >98%

    melanocortin 4 (MC4) receptor agonist

  • GC18458 structure
    GC18458Terrein
    CAS: 582-46-7
    Purity: >98.00%

    Terrein is a fungal metabolite produced by A.

  • GC30194 structure
    GC30194JNJ-10229570
    CAS: 524923-88-4
    Purity: >98.00%

    JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids.

  • GC31109 structure
    GC31109ACTH 1-17 (α1-17-ACTH)
    CAS: 7266-47-9
    Purity: >98%

    ACTH 1-17 (α1-17-ACTH), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.

  • GC31560 structure
    GC31560SNT-207858
    CAS: 1104080-42-3
    Purity: >98%

    SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist.

  • GC31600 structure
    GC31600SNT-207707
    CAS: 1064662-40-3
    Purity: >99.00%

    SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

  • GC31629 structure
    GC31629MC-4R Agonist 1
    CAS: 455957-28-5
    Purity: >98%

    MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R), used in the research of obesity, diabetes, and sexual dysfunction.

  • GC31954 structure
    GC31954ACTH 11-24 (Adrenocorticotropic Hormone (11-24))
    CAS: 4237-93-8
    Purity: >98%

    ACTH 11-24 (Adrenocorticotropic Hormone (11-24)) is an adrenocorticotropic hormone (ACTH) receptor antagonist.

  • GC33693 structure
    GC33693β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human))
    CAS: 17908-57-5
    Purity: >98%

    β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)), a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.