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Terrein (Synonyms: NSC 291308)

Catalog No.GC18458 Copy One-Click Copy Product Info

Terrein is a fungal metabolite produced by A.

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Terrein Chemical Structure

Cas No.: 582-46-7

Size Price Stock Qty
1mg
$187.00
In stock
5mg
$656.00
In stock
10mg
$1,030.00
In stock

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Customer Reviews

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Sample solution is provided at 25 µL, 10mM.



Product has been cited by 1 publications

Description of Terrein

Terrein is a fungal metabolite produced by A. terreus with diverse biological activities. It reduces melanin production in Mel-Ab mouse melanocytes in a dose-dependent manner via ERK activation and downregulation of microphthalmia-associated transcription factor (MITF). Terrein inhibits proliferation of human keratinocytes and thins the epidermis in a skin equivalent model of psoriasis vulgaris. It is antimicrobial, inhibiting the growth of S. aureus, A. hydrophila, E. faecalis, A. flavus, A. alternata, B. sorokiniana, and P. drechsleri (MICs = 1-40 μg/ml). Terrein also inhibits growth of A549 lung cancer cells in a dose-dependent manner.

Chemical Properties of Terrein

Cas No. 582-46-7 SDF
Synonyms NSC 291308
Chemical Name 4S,5R-dihydroxy-3-(1E)-1-propen-1-yl-2-cyclopenten-1-one
Canonical SMILES O=C1[C@H](O)[C@@H](O)C(/C=C/C)=C1
Formula C8H10O3 M.Wt 154.2
Solubility DMSO: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Terrein

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 6.4851 mL 32.4254 mL 64.8508 mL
5 mM 1.297 mL 6.4851 mL 12.9702 mL
10 mM 648.5 μL 3.2425 mL 6.4851 mL
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In vivo Formulation Calculator (Clear solution) of Terrein

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Reviews

Review for Terrein

Average Rating: 5 ★★★★★ (Based on Reviews and 20 reference(s) in Google Scholar.)

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