MM 07 is an apelin-biased receptor agonist with KD of 300 nM in CHO-K1 cells and 172 nM in human heart.
MM 07 competes with nanomolar affinity for binding to [Glp65,Nle75,Tyr77] [125I]apelin-13 is receptor-dependent on human apelin in CHO-K1 cells (KD, 300 nM) and human heart (KD, 172 nM, n=3). body [1].
MM 07 caused a dose-dependent increase in cardiac output with no corresponding effect on blood pressure despite a decrease in vascular resistance. In both the [Pyr1]apelin-13 and MM 07-treated groups, SNAP administration resulted in a significant decrease in blood pressure; however, while SNAP-responsive cardiac output was significantly increased in the MM 07 group, the [Pyr1]apelin-13 group Cardiac output is significantly reduced. Neither peptide caused significant changes in heart rate, breathing rate or temperature. [Pyr1] Both apelin 13 and MM 07 increase the peak speed above the base level [1].
References:
[1]. Brame AL et al. Design, characterization, and first-in-human studies of a novel biased apelin receptor agonist for vascular effects. hypertension. 2015 Apr;65(4):834-40.