GLPBio

Nirvanol

Catalog No.: GC49501Purity:>98.00%Synonyms: rac-N-Desmethyl Mephenytoin, NSC 150466, NSC 33388, Phenylethylhydantoin
COASDSData Sheet
An active metabolite of mephenytoin

Products are for research use only. Not for human use. We do not sell to patients.

Nirvanol
Cas No.: 631-07-2
5mgIn Stock
$59.00
1
10mgIn Stock
$92.00
1
25mgIn Stock
$180.00
1
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Citations

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

Nirvanol is an active metabolite of mephenytoin, a substrate of the cytochrome P450 (CYP) isoform CYP2C19 with anticonvulsant activities.1 It blocks the hind leg tonic extensor phase in a mouse model of seizures induced by maximal electroshock (MES; ED50 = 30 mg/kg).

1.Kupferberg, H.J., and Yonekawa, W.The metabolism of 3-methyl-5-ethyl-5-phenylhydantoin (mephenytoin) to 5-ethyl-5-phenylhydantoin (nirvanol) in mice in relation to anticonvulsant activityDrug Metab. Dispos.3(1)26-29(1975)

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
631-07-2
Synonyms
rac-N-Desmethyl Mephenytoin, NSC 150466, NSC 33388, Phenylethylhydantoin
SMILES
O=C(N1)C(C2=CC=CC=C2)(CC)NC1=O
Molecular Formula
C11H12N2O2
Molecular Weight
204.2
Solubility
DMSO: soluble
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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