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Home >> Lipids >> P450

P450

Products for  P450

  1. Cat.No. Product Name Information
  2. GC66197 α-?Terpinyl acetate α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM. α-?Terpinyl acetate Chemical Structure
  3. GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol. α-hydroxy Metoprolol Chemical Structure
  4. GC63272 β-Apo-8’-carotenal β-Apo-8'-carotenal (Apocarotenal), a provitamin A carotenoid, is an inducer of CYPlA1 and CYPlA2 in rat. β-Apo-8'-carotenal is present in many fruits and vegetables. β-Apo-8’-carotenal Chemical Structure
  5. GC45239 δ4-Abiraterone δ4-Abiraterone is a major metabolite of abiraterone. δ4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor. δ4-Abiraterone Chemical Structure
  6. GC40112 (±)-Climbazole-d4 (±)-Climbazole-d4 is intended for use as an internal standard for the quantification of climbazole by GC- or LC-MS. (±)-Climbazole-d4 Chemical Structure
  7. GC46284 (±)-Cotinine-d3 An internal standard for the quantification of cotinine (±)-Cotinine-d3 Chemical Structure
  8. GC40954 (±)-N-3-Benzylnirvanol (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-benzylnirvanol and (-)-N-3-benzylnirvanol. (±)-N-3-Benzylnirvanol Chemical Structure
  9. GC45269 (±)10(11)-DiHDPA (±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid. (±)10(11)-DiHDPA Chemical Structure
  10. GC45270 (±)10(11)-EDP Ethanolamide (±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). (±)10(11)-EDP Ethanolamide Chemical Structure
  11. GC41212 (±)10(11)-EpDPA Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA Chemical Structure
  12. GC49439 (±)11(12)-DiHET MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications (±)11(12)-DiHET MaxSpec® Standard Chemical Structure
  13. GC40466 (±)11(12)-EET

    (±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.

     (±)11(12)-EET Chemical Structure
  14. GC40386 (±)11(12)-EpETE Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. (±)11(12)-EpETE Chemical Structure
  15. GC41143 (±)11,12-DiHETE (±)11,12-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. (±)11,12-DiHETE Chemical Structure
  16. GC40802 (±)12(13)-DiHOME

    (±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.

     (±)12(13)-DiHOME Chemical Structure
  17. GC41648 (±)13(14)-DiHDPA (±)13(14)-DiHDPA is a metabolite of docosahexaenoic acid that is produced via oxidation by cytochrome P450 epoxygenases. (±)13(14)-DiHDPA Chemical Structure
  18. GC41191 (±)13(14)-EpDPA Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA Chemical Structure
  19. GC40430 (±)14(15)-EET

    (±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450.

     (±)14(15)-EET Chemical Structure
  20. GC41651 (±)14(15)-EET-SI Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. (±)14(15)-EET-SI Chemical Structure
  21. GC41652 (±)14(15)-EpEDE 8,11,14-Eicosatrienoic acid, also known as dihomo-γ-linolenic acid, is a polyunsaturated fatty acid (PUFA) produced from γ-linolenic acid by the action of fatty acid elongases. (±)14(15)-EpEDE Chemical Structure
  22. GC40360 (±)14(15)-EpETE EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. (±)14(15)-EpETE Chemical Structure
  23. GC41653 (±)16(17)-DiHDPA (±)16(17)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid. (±)16(17)-DiHDPA Chemical Structure
  24. GC41194 (±)16(17)-EpDPA

    EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.

     (±)16(17)-EpDPA Chemical Structure
  25. GC40434 (±)16-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE Chemical Structure
  26. GC41117 (±)17(18)-DiHETE Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. (±)17(18)-DiHETE Chemical Structure
  27. GC41288 (±)17(18)-EpETE-Ethanolamide (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. (±)17(18)-EpETE-Ethanolamide Chemical Structure
  28. GC40435 (±)17-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE Chemical Structure
  29. GC40436 (±)18-HETE (±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. (±)18-HETE Chemical Structure
  30. GC40388 (±)19(20)-DiHDTE (±)19(20)-DiHDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid. (±)19(20)-DiHDTE Chemical Structure
  31. GC41655 (±)19(20)-EDP Ethanolamide (±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). (±)19(20)-EDP Ethanolamide Chemical Structure
  32. GC41199 (±)19(20)-EpDPA EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. (±)19(20)-EpDPA Chemical Structure
  33. GC40905 (±)19(20)-EpDTE (±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid. (±)19(20)-EpDTE Chemical Structure
  34. GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol Chemical Structure
  35. GC41201 (±)4(5)-DiHDPA lactone (±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET, which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5 double bond. (±)4(5)-DiHDPA lactone Chemical Structure
  36. GC41660 (±)4(5)-EpDPA methyl ester (±)4(5)-EpDPA methyl ester is a derivative of (±)4(5)-EpDPA which is stable enough to ship and handle routinely. (±)4(5)-EpDPA methyl ester Chemical Structure
  37. GC40270 (±)5(6)-DiHET

    5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

     (±)5(6)-DiHET Chemical Structure
  38. GC40437 (±)5(6)-DiHET lactone 5,6-DiHET lactone is a lactonized form of 5,6-EET and 5,6-DiHET. (±)5(6)-DiHET lactone Chemical Structure
  39. GC41119 (±)5(6)-DiHETE Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils. (±)5(6)-DiHETE Chemical Structure
  40. GC40363 (±)5(6)-DiHETE lactone Eicosapentaenoic acid is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE lactone Chemical Structure
  41. GC40438 (±)5(6)-EET 5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. (±)5(6)-EET Chemical Structure
  42. GC41319 (±)5(6)-EpETE methyl ester (±)5(6)-EpETE methyl ester is a derivative of 5(6)-EpETE which is stable enough to ship and handle routinely. (±)5(6)-EpETE methyl ester Chemical Structure
  43. GC41663 (±)7(8)-DiHDPA (±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid that is produced via oxidation by cytochrome P450 epoxygenases. (±)7(8)-DiHDPA Chemical Structure
  44. GC41203 (±)7(8)-EpDPA Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA Chemical Structure
  45. GC40906 (±)7(8)-EpDTE (±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid. (±)7(8)-EpDTE Chemical Structure
  46. GC40272 (±)8(9)-DiHET Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. (±)8(9)-DiHET Chemical Structure
  47. GC40365 (±)8(9)-EpETE Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. (±)8(9)-EpETE Chemical Structure
  48. GC41120 (±)8,9-DiHETE

    (±)8,9-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid.

     (±)8,9-DiHETE Chemical Structure
  49. GC40801 (±)9(10)-DiHOME Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst. (±)9(10)-DiHOME Chemical Structure
  50. GC40443 (±)9-HETE (±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. (±)9-HETE Chemical Structure
  51. GC12404 (+)-Ketoconazole Potent inhibitor of cytochrome P450c17 (+)-Ketoconazole Chemical Structure
  52. GC30424 (-)-Cephaeline dihydrochloride (NSC 32944) (-)-Cephaeline dihydrochloride (NSC 32944) is a selective CYP2D6 inhibtor with an IC50 of 121 μM. (-)-Cephaeline dihydrochloride (NSC 32944) Chemical Structure
  53. GC18622 (2'S)-Nicotine-1-oxide (2'S)-Nicotine-1-oxide is a metabolite of nicotine . (2'S)-Nicotine-1-oxide Chemical Structure
  54. GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite. (3S)-hydroxy Quinidine Chemical Structure
  55. GC39746 (3S,5S)-Atorvastatin (3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin Chemical Structure
  56. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen (E/Z)-4-hydroxy Tamoxifen-d5 Chemical Structure
  57. GC18286 (R)-Mephenytoin

    (R)-Mephenytoin is the (R) enantiomer of the anticonvulsant mephenytoin.

     (R)-Mephenytoin Chemical Structure
  58. GC41720 (R)-Omeprazole (sodium salt) (R)-Omeprazole is the inactive isomer of omeprazole, a gastric proton-pump inhibitor. (R)-Omeprazole (sodium salt) Chemical Structure
  59. GC14486 (S)-Mephenytoin

    S-Mephenytoin is an anticonvulsive drug which is metabolized by N-demethylation and 4-hydroxylation .

     (S)-Mephenytoin Chemical Structure
  60. GC41837 1,3,7-Trimethyluric Acid

    1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.

     1,3,7-Trimethyluric Acid Chemical Structure
  61. GC46387 1,3,7-Trimethyluric Acid-d9 An internal standard for the quantification of 1,3,7-trimethyluric acid 1,3,7-Trimethyluric Acid-d9 Chemical Structure
  62. GC33073 1-Ethynylnaphthalene 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. 1-Ethynylnaphthalene Chemical Structure
  63. GC60446 1-Ethynylpyrene 1-Ethynylpyrene is an aryl acetylenic inhibitor of cytochromes P450 1A1, 1A2, and 2B1 with IC50s of 0.18, 0.32, and 0.04 μM, respectively. 1-Ethynylpyrene Chemical Structure
  64. GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin 10-hydroxy Warfarin Chemical Structure
  65. GC40447 12(R)-HETE Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid. 12(R)-HETE Chemical Structure
  66. GC18783 13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. 13,14-dihydro-15-keto Prostaglandin E1 Chemical Structure
  67. GC40424 14,15-EE-5(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E Chemical Structure
  68. GC40425 14,15-EE-8(Z)-E Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E Chemical Structure
  69. GC46438 14S(15R)-EET A cytochrome P450 metabolite of arachidonic acid 14S(15R)-EET Chemical Structure
  70. GC40454 16(S)-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16(S)-HETE Chemical Structure
  71. GC41945 16-hydroxy Hexadecanoic Acid 16-hydroxy Hexadecanoic acid is a metabolite of the saturated fatty acid palmitic acid (16:0) that has been hydroxylated on its terminal (ω) carbon. 16-hydroxy Hexadecanoic Acid Chemical Structure
  72. GC41300 17β-hydroxy Exemestane 17β-hydroxy Exemestane is the primary active metabolite of exemestane. 17β-hydroxy Exemestane Chemical Structure
  73. GC40455 17(R)-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17(R)-HETE Chemical Structure
  74. GC40456 17(S)-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17(S)-HETE Chemical Structure
  75. GC46464 17R(18S)-EpETE An EPA metabolite and activator of BKCa channels 17R(18S)-EpETE Chemical Structure
  76. GC40457 19(R)-HETE 19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. 19(R)-HETE Chemical Structure
  77. GC40458 19(S)-HETE 19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. 19(S)-HETE Chemical Structure
  78. GC46475 19R(20S)-EpDPA A DHA metabolite 19R(20S)-EpDPA Chemical Structure
  79. GC13836 2,3-dihydrothieno-Thiadiazole Carboxylate CYP450 enzymes (CYP2E1 and CYP2B4) inhibitor 2,3-dihydrothieno-Thiadiazole Carboxylate Chemical Structure
  80. GC61722 2,6-Dimethylquinoline 2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 ?M. 2,6-Dimethylquinoline Chemical Structure
  81. GC49159 2-(1-Piperazinyl)pyrimidine An α2-AR antagonist and active metabolite of azapirones 2-(1-Piperazinyl)pyrimidine Chemical Structure
  82. GC49362 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline A food-derived carcinogen 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline Chemical Structure
  83. GC12262 2-Phenyl-2-(1-piperidinyl)propane mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 2-Phenyl-2-(1-piperidinyl)propane Chemical Structure
  84. GC41104 20-carboxy Arachidonic Acid 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. 20-carboxy Arachidonic Acid Chemical Structure
  85. GC40377 20-HEPE 20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. 20-HEPE Chemical Structure
  86. GC42083 20-HETE Ethanolamide Arachidonoyl ethanolamide (AEA) is an endogenous lipid neurotransmitter with cannabinergic activity, binding both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. 20-HETE Ethanolamide Chemical Structure
  87. GC41474 20-hydroxy Prostaglandin E2 20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2. 20-hydroxy Prostaglandin E2 Chemical Structure
  88. GC40534 20-hydroxy Prostaglandin F2α 20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. 20-hydroxy Prostaglandin F2α Chemical Structure
  89. GC52083 21-Deoxycortisone A corticosteroid metabolite of 11-keto progesterone 21-Deoxycortisone Chemical Structure
  90. GC40968 21-hydroxy Eplerenone 21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone. 21-hydroxy Eplerenone Chemical Structure
  91. GC41480 3'-hydroxy Lidocaine 3'-hydroxy Lidocaine is an active metabolite of lidocaine formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. 3'-hydroxy Lidocaine Chemical Structure
  92. GC49169 3,8’-Biapigenin A biflavonoid with diverse biological activities 3,8’-Biapigenin Chemical Structure
  93. GC18817 3β-hydroxy-5-Cholestenoic Acid 3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3β-hydroxy-5-Cholestenoic Acid Chemical Structure
  94. GC46678 4β-hydroxy Cholesterol-d7 An internal standard for the quantification of 4β-hydroxy cholesterol 4β-hydroxy Cholesterol-d7 Chemical Structure
  95. GC18527 4'-hydroxy Flurbiprofen A major active metabolite of flurbiprofen 4'-hydroxy Flurbiprofen Chemical Structure
  96. GC33071 4'-Methylchrysoeriol 4'-Methylchrysoeriol is a potent inhibitor of Cytochrome P450 enzymes, with an IC50 of 19 nM for human P450 1B1-dependent EROD. 4'-Methylchrysoeriol Chemical Structure
  97. GC65517 4-(Trifluoromethyl)umbelliferone 4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes. 4-(Trifluoromethyl)umbelliferone Chemical Structure
  98. GC42405 4-hydroxy Atorvastatin (calcium salt) 4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. 4-hydroxy Atorvastatin (calcium salt) Chemical Structure
  99. GC18425 4-hydroxy Atorvastatin lactone

    4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.

     4-hydroxy Atorvastatin lactone Chemical Structure
  100. GC11758 4-phenyl-5-methyl-1,2,3-Thiadiazole CYP2B4 and CYP2E1 inhibitor 4-phenyl-5-methyl-1,2,3-Thiadiazole Chemical Structure
  101. GC18582 5'-hydroxy Meloxicam A metabolite of meloxicam 5'-hydroxy Meloxicam Chemical Structure

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