Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Products Related to Drug Metabolite(546)
- GC10822Clozapine N-oxide (CNO)CAS: 34233-69-7Purity: >98.00%
Clozapine N-oxide (CNO) is a ligand for the DREADD system used in chemogenetic research.
- GC11155Omeprazole sulfoneCAS: 88546-55-8Purity: >98%
Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
- GC11989Nortriptyline (hydrochloride)CAS: 894-71-3Purity: >99.50%
norepinephrine and serotonin transporters blocker
- GC15168Urolithin ACAS: 1143-70-0Purity: >98.50%
Urolithin A is a metabolite generated from ellagic acid and ellagitannins, acting as a potent inhibitor of tyrosinase (IC 50 value of 71.44±10.07µmol/L) and Monoamine Oxidase A(IC 50 value of 29.41±9.01µmol/L).
- GC16333Cycloguanil (hydrochloride)CAS: 152-53-4Purity: >99.50%
inhibitor of dihydrofolate reductase (DHFR)
- GC181944-EpidoxycyclineCAS: 6543-77-7Purity: >98%
4-Epidoxycycline is the 4-epimer hepatic metabolite of the antibiotic doxycycline .
- GC182196-hydroxy WarfarinCAS: 17834-02-5Purity: >98.00%
6-hydroxy Warfarin is a metabolite of (+)-warfarin , which is a weaker vitamin K antagonist than (-)-warfarin .
- GC183356β-hydroxy DexamethasoneCAS: 55879-47-5Purity: >98%
6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound.
- GC184174-hydroxy XylazineCAS: 145356-32-7Purity: >97.50%
4-hydroxy Xylazine is a metabolite of xylazine .
- GC184254-hydroxy Atorvastatin lactoneCAS: 163217-70-7Purity: >98%
4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
- GC18455Digoxigenin MonodigitoxosideCAS: 5352-63-6Purity: >98%
Digoxigenin monodigitoxoside is a Na+/K+-ATPase inhibitor and cardiac glycoside metabolite of digoxin .
- GC184665,6-epoxy-13-cis Retinoic AcidCAS: 81444-57-7Purity: >98%
5,6-epoxy-13-cis Retinoic acid is a metabolite of 13-cis retinoic acid.
- GC185394-Hydroxyretinoic acid (4-HRA)CAS: 66592-72-1Purity: >98.00%
4-Hydroxyretinoic acid (4-HRA) is a naturally occurring, primary metabolite derived from all-trans retinoic acid (ATRA) via cytochrome P450 enzyme metabolism.
- GC185425,6-dihydro-5-FluorouracilCAS: 696-06-0Purity: >95.00%
5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD).
- GC18569Propofol β-D-GlucuronideCAS: 114991-26-3Purity: >98.00%
Propofol β-D-Glucuronide is a metabolite of propofol and is widely used as a marker to identify the metabolic status of propofol in animals.
- GC18596(±)-2-propyl-4-Pentenoic AcidCAS: 1575-72-0Purity: >98.00%
(±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid .
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10822 | Clozapine N-oxide (CNO) | 34233-69-7 | >98.00% | |
Clozapine N-oxide (CNO) is a ligand for the DREADD system used in chemogenetic research. | ||||
| GC11155 | Omeprazole sulfone | 88546-55-8 | >98% | |
Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor. | ||||
| GC11989 | Nortriptyline (hydrochloride) | 894-71-3 | >99.50% | |
norepinephrine and serotonin transporters blocker | ||||
| GC12685 | Ercalcitriol | 60133-18-8 | >99.00% | |
A potent agonist of the vitamin D receptor | ||||
| GC14762 | Palifosfamide | 31645-39-3 | >98% | |
An active metabolite of ifosfamide | ||||
| GC14780 | Oseltamivir acid | 187227-45-8 | >98.00% | |
A neuraminidase inhibitor and antiviral | ||||
| GC15168 | Urolithin A | 1143-70-0 | >98.50% | |
Urolithin A is a metabolite generated from ellagic acid and ellagitannins, acting as a potent inhibitor of tyrosinase (IC 50 value of 71.44±10.07µmol/L) and Monoamine Oxidase A(IC 50 value of 29.41±9.01µmol/L). | ||||
| GC16292 | Equol | 94105-90-5 | >98.00% | |
non-steroidal estrogen | ||||
| GC16333 | Cycloguanil (hydrochloride) | 152-53-4 | >99.50% | |
inhibitor of dihydrofolate reductase (DHFR) | ||||
| GC16553 | N-Desmethylclozapine | 6104-71-8 | >99.50% | |
5-HT2C serotonin receptor antagonist | ||||
| GC18194 | 4-Epidoxycycline | 6543-77-7 | >98% | |
4-Epidoxycycline is the 4-epimer hepatic metabolite of the antibiotic doxycycline . | ||||
| GC18219 | 6-hydroxy Warfarin | 17834-02-5 | >98.00% | |
6-hydroxy Warfarin is a metabolite of (+)-warfarin , which is a weaker vitamin K antagonist than (-)-warfarin . | ||||
| GC18335 | 6β-hydroxy Dexamethasone | 55879-47-5 | >98% | |
6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. | ||||
| GC18417 | 4-hydroxy Xylazine | 145356-32-7 | >97.50% | |
4-hydroxy Xylazine is a metabolite of xylazine . | ||||
| GC18425 | 4-hydroxy Atorvastatin lactone | 163217-70-7 | >98% | |
4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. | ||||
| GC18439 | Doxorubicinone | 24385-10-2 | >95.00% | |
A metabolite of doxorubicin | ||||
| GC18455 | Digoxigenin Monodigitoxoside | 5352-63-6 | >98% | |
Digoxigenin monodigitoxoside is a Na+/K+-ATPase inhibitor and cardiac glycoside metabolite of digoxin . | ||||
| GC18466 | 5,6-epoxy-13-cis Retinoic Acid | 81444-57-7 | >98% | |
5,6-epoxy-13-cis Retinoic acid is a metabolite of 13-cis retinoic acid. | ||||
| GC18527 | 4'-hydroxy Flurbiprofen | 52807-12-2 | >98% | |
A major active metabolite of flurbiprofen | ||||
| GC18539 | 4-Hydroxyretinoic acid (4-HRA) | 66592-72-1 | >98.00% | |
4-Hydroxyretinoic acid (4-HRA) is a naturally occurring, primary metabolite derived from all-trans retinoic acid (ATRA) via cytochrome P450 enzyme metabolism. | ||||
| GC18542 | 5,6-dihydro-5-Fluorouracil | 696-06-0 | >95.00% | |
5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD). | ||||
| GC18569 | Propofol β-D-Glucuronide | 114991-26-3 | >98.00% | |
Propofol β-D-Glucuronide is a metabolite of propofol and is widely used as a marker to identify the metabolic status of propofol in animals. | ||||
| GC18582 | 5'-hydroxy Meloxicam | 130262-92-9 | >98% | |
A metabolite of meloxicam | ||||
| GC18596 | (±)-2-propyl-4-Pentenoic Acid | 1575-72-0 | >98.00% | |
(±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid . | ||||