NT160 is a highly potent class-IIa HDAC inhibitor with an IC50 value of 0.046 μM. NT160 can be used for the research of central nervous system diseases.
NT160 has affinity for class-IIa HDAC4 isoform with an IC50 value of 0.046 μM[1].
NT160 exhibites a remarkably high inhibition against HDAC4, HDAC5, HDAC7 and HDAC9 with IC50 values of 0.08 nM, 1.2 nM, 1.0 nM and0.9 nM, respectively[1].
References:
[1]. Turkman N, et al. Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy. Eur J Med Chem. 2022;228:114011.