OD 36 hydrochloride |
| Catalog No.GC50517 |
OD 36 hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1638644-62-8
Sample solution is provided at 25 µL, 10mM.
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Potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.
Tigno-Aranjuez et al (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J.Biol.Chem. 289 29651 PMID:25213858 |SÁnchez-Duffhues et al (2019) Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells. JBMRPlus 3 e10230 PMID:31768489
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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