Amyloid β protein
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Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.
The normal function of Aβ is not well understood. Though some animal studies have shown that the absence of Aβ does not lead to any obvious loss of physiological function, several potential activities have been discovered for Aβ, including activation of kinase enzymes, protection against oxidative stress, regulation of cholesterol transport, functioning as a transcription factor, and anti-microbial activity (potentially associated with Aβ's pro-inflammatory activity).
The glymphatic system clears metabolic waste from the mammalian brain, and in particular amyloid beta. Indeed, a number of proteases have been implicated by both genetic and biochemical studies as being responsible for the recognition and degradation of amyloid beta; these include insulin degrading enzyme.and presequence protease. The rate of removal is significantly increased during sleep. However, the significance of the lymphatic system in Aβ clearance in Alzheimer's disease is unknown.
Products Related to Amyloid β protein(166)
- GC37984β-Amyloid (1-42), ratCAS: 166090-74-0Purity: >95.00%
β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.
- GC37985β-Amyloid 11-22CAS: 885323-98-8Purity: >98%
β-Amyloid 11-22 is a peptide fragment of β-Amyloid.
- GC37986β-Amyloid 1-17CAS: 186319-72-2Purity: >98%
β-Amyloid 1-17 is a peptide of β-Amyloid, stabilizes the fibres and plays a role in Aβ fibre formation.
- GC37987β-Amyloid 1-20CAS: 186319-68-6Purity: >98%
β-Amyloid 1-20 consists of amino acids 1 to 20 of beta amyloid protein.
- GC37988β-Amyloid 12-20CAS: 134649-29-9Purity: >98%
β-Amyloid 12-20 is a peptide fragment of β-Amyloid.
- GC37989β-Amyloid 13-27CAS: 148270-13-7Purity: >98%
β-Amyloid 13-27 is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein.
- GC37990β-Amyloid 1-34CAS: 186359-65-9Purity: >98%
β-Amyloid 1-34 is a β-Amyloid peptide consists of 34 amino acid.
- GC37992β-Amyloid 18-28CAS: 112163-49-2Purity: >98%
β-Amyloid 18-28 is a peptide fragment of β-Amyloid.
- GC37993β-Amyloid 1-9CAS: 147529-30-4Purity: >98%
β-Amyloid 1-9, an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9.
- GC37994β-Amyloid 22-40CAS: 1206779-25-0Purity: >98%
β-Amyloid 22-40 is a peptide fragment of β-Amyloid.
- GC37995β-Amyloid 33-40CAS: 634204-57-2Purity: >98%
β-Amyloid 33-40 is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.
- GC37996β-Amyloid 35-42CAS: 183292-41-3Purity: >98.00%
β-Amyloid 35-42 is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein.
- GC37997β-Amyloid 4-10CAS: 477284-32-5Purity: >98%
β-Amyloid 4-10 is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model.
- GC37998β-Amyloid Protein Precursor 770 135-155CAS: 315229-44-8Purity: >98%
β-Amyloid Protein Precursor 770 135-155 is a peptide of amyloid precursor protein isoform (APP 770).
- GC40126Amyloid-β Precursor Protein (96-110) Peptide (cyclized) (human) (trifluoroacetate salt)Purity: >95.00%
Amyloid-β precursor protein (96-110) peptide (cyclized) is a synthetic peptide consisting of amino acids 96-110 of amyloid precursor peptide (APP) that is cyclized via a bridge between the cysteine residues at positions 3 and 10.
- GC40127Amyloid-β (22-35) Peptide (trifluoroacetate salt)Purity: >95.00%
Amyloid-β (Aβ) (22-35) is a 13-residue fragment of Aβ that corresponds to residues 693-705 of the human amyloid precursor protein (APP) full-length sequence.
- GC40128TAMRA-Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
TAMRA-Amyloid-β (1-40) peptide is a fluorescently labeled peptide.
- GC40129Biotin-Amyloid-β (1-40) Peptide (trifluoroacetate salt)Purity: >95.00%
Biotin-amyloid-β (1-40) (biotin-Aβ40) is an affinity probe that allows amyloid-β (1-40) (Aβ40) to be detected or immobilized through interaction with the biotin ligand.
- GC401305-FAM-Amyloid-β (1-42) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
5-FAM-Amyloid-β (1-42) peptide is a fluorescently labeled amyloid-β peptide.
- GC40160Biotin-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
Biotin-amyloid-β (1-28) peptide is a biotinylated peptide.
- GC425055-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
5-FAM-Amyloid-β (1-28) peptide is a fluorescently labeled peptide.
- GC42798Amyloid-β (1-38) Peptide (trifluoroacetate salt)Purity: >95.00%
Amyloid-β (1-38) (Aβ38) peptide is a fragment of the Aβ42 peptide.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC37984 | β-Amyloid (1-42), rat | 166090-74-0 | >95.00% | |
β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease. | ||||
| GC37985 | β-Amyloid 11-22 | 885323-98-8 | >98% | |
β-Amyloid 11-22 is a peptide fragment of β-Amyloid. | ||||
| GC37986 | β-Amyloid 1-17 | 186319-72-2 | >98% | |
β-Amyloid 1-17 is a peptide of β-Amyloid, stabilizes the fibres and plays a role in Aβ fibre formation. | ||||
| GC37987 | β-Amyloid 1-20 | 186319-68-6 | >98% | |
β-Amyloid 1-20 consists of amino acids 1 to 20 of beta amyloid protein. | ||||
| GC37988 | β-Amyloid 12-20 | 134649-29-9 | >98% | |
β-Amyloid 12-20 is a peptide fragment of β-Amyloid. | ||||
| GC37989 | β-Amyloid 13-27 | 148270-13-7 | >98% | |
β-Amyloid 13-27 is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein. | ||||
| GC37990 | β-Amyloid 1-34 | 186359-65-9 | >98% | |
β-Amyloid 1-34 is a β-Amyloid peptide consists of 34 amino acid. | ||||
| GC37991 | β-Amyloid 15-21 | - | >98% | |
| GC37992 | β-Amyloid 18-28 | 112163-49-2 | >98% | |
β-Amyloid 18-28 is a peptide fragment of β-Amyloid. | ||||
| GC37993 | β-Amyloid 1-9 | 147529-30-4 | >98% | |
β-Amyloid 1-9, an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. | ||||
| GC37994 | β-Amyloid 22-40 | 1206779-25-0 | >98% | |
β-Amyloid 22-40 is a peptide fragment of β-Amyloid. | ||||
| GC37995 | β-Amyloid 33-40 | 634204-57-2 | >98% | |
β-Amyloid 33-40 is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein. | ||||
| GC37996 | β-Amyloid 35-42 | 183292-41-3 | >98.00% | |
β-Amyloid 35-42 is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein. | ||||
| GC37997 | β-Amyloid 4-10 | 477284-32-5 | >98% | |
β-Amyloid 4-10 is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model. | ||||
| GC37998 | β-Amyloid Protein Precursor 770 135-155 | 315229-44-8 | >98% | |
β-Amyloid Protein Precursor 770 135-155 is a peptide of amyloid precursor protein isoform (APP 770). | ||||
| GC39466 | β-Amyloid 15-21 | - | >98% | |
| GC40126 | Amyloid-β Precursor Protein (96-110) Peptide (cyclized) (human) (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β precursor protein (96-110) peptide (cyclized) is a synthetic peptide consisting of amino acids 96-110 of amyloid precursor peptide (APP) that is cyclized via a bridge between the cysteine residues at positions 3 and 10. | ||||
| GC40127 | Amyloid-β (22-35) Peptide (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β (Aβ) (22-35) is a 13-residue fragment of Aβ that corresponds to residues 693-705 of the human amyloid precursor protein (APP) full-length sequence. | ||||
| GC40128 | TAMRA-Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
TAMRA-Amyloid-β (1-40) peptide is a fluorescently labeled peptide. | ||||
| GC40129 | Biotin-Amyloid-β (1-40) Peptide (trifluoroacetate salt) | - | >95.00% | |
Biotin-amyloid-β (1-40) (biotin-Aβ40) is an affinity probe that allows amyloid-β (1-40) (Aβ40) to be detected or immobilized through interaction with the biotin ligand. | ||||
| GC40130 | 5-FAM-Amyloid-β (1-42) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
5-FAM-Amyloid-β (1-42) peptide is a fluorescently labeled amyloid-β peptide. | ||||
| GC40160 | Biotin-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
Biotin-amyloid-β (1-28) peptide is a biotinylated peptide. | ||||
| GC42505 | 5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
5-FAM-Amyloid-β (1-28) peptide is a fluorescently labeled peptide. | ||||
| GC42798 | Amyloid-β (1-38) Peptide (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β (1-38) (Aβ38) peptide is a fragment of the Aβ42 peptide. | ||||