Amyloid β protein
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Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.
The normal function of Aβ is not well understood. Though some animal studies have shown that the absence of Aβ does not lead to any obvious loss of physiological function, several potential activities have been discovered for Aβ, including activation of kinase enzymes, protection against oxidative stress, regulation of cholesterol transport, functioning as a transcription factor, and anti-microbial activity (potentially associated with Aβ's pro-inflammatory activity).
The glymphatic system clears metabolic waste from the mammalian brain, and in particular amyloid beta. Indeed, a number of proteases have been implicated by both genetic and biochemical studies as being responsible for the recognition and degradation of amyloid beta; these include insulin degrading enzyme.and presequence protease. The rate of removal is significantly increased during sleep. However, the significance of the lymphatic system in Aβ clearance in Alzheimer's disease is unknown.
Products Related to Amyloid β protein(166)
- GC42799Amyloid-β (17-40) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
Amyloid-β (Aβ) (17-40) is a 24-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases.
- GC42800Amyloid-β (17-42) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
Amyloid-β (Aβ) (17-42) is a 26-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases.
- GC42801Amyloid-β (1-8) PeptidePurity: >98.00%
Amyloid-β (1-8) is a wild-type control for the mutation-containing amyloid-β (1-8, A2V) peptide .
- GC42802Amyloid-β (1-8, A2V) PeptidePurity: >98.00%
Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V).
- GC42803Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide.
- GC42804Amyloid-β (40-1) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
Amyloid-β (40-1) peptide (Aβ (40-1)) is a peptide that contains the reverse sequence of Aβ (1-40) peptide.
- GC42937Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)Purity: >95.00%
Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand.
- GC43650FAM-Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
FAM-Amyloid-β (1-40) peptide is a fluorescently labeled amyloid-β peptide.
- GC44986TAMRA-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
TAMRA-Amyloid-β (1-28) peptide is a fluorescently labeled peptide.
- GC44987TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)Purity: >95.00%
TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide.
- GC46850Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
A neuropeptide with diverse biological activities
- GC46851Amyloid-β (1-42) Peptide (trifluoroacetate salt)Purity: >95.00%
A 42-amino acid protein fragment of amyloid-β
- GP10049Amyloid Beta-Peptide (12-28) (human)CAS: 107015-83-8Purity: >95.00%
Amyloid Beta-Peptide (12-28) (human) is a peptide fragment of amyloid beta protein (1-42) (Aβ (1-42)).
- GP10082Amyloid Beta-peptide (25-35) (human)CAS: 131602-53-4Purity: >98.50%
Amyloid beta(Aβ)-peptide (25-35) (human) is an fragment of Alzheimer's Amyloid beta peptide which is commonly found in the brains of people with Alzheimer's disease (AD) and is a major component of Alzheimer's amyloid plaques.
- GP10118Amyloid Beta-Peptide (1-40) (human)CAS: 131438-79-4Purity: >96.00%
Amyloid Beta-Peptide (1-40) (human) is the main component of senile plaque amyloid and is a physiological peptide present in the brain, cerebrospinal fluid (CSF), and plasma.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC42799 | Amyloid-β (17-40) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β (Aβ) (17-40) is a 24-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases. | ||||
| GC42800 | Amyloid-β (17-42) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β (Aβ) (17-42) is a 26-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases. | ||||
| GC42801 | Amyloid-β (1-8) Peptide | - | >98.00% | |
Amyloid-β (1-8) is a wild-type control for the mutation-containing amyloid-β (1-8, A2V) peptide . | ||||
| GC42802 | Amyloid-β (1-8, A2V) Peptide | - | >98.00% | |
Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). | ||||
| GC42803 | Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. | ||||
| GC42804 | Amyloid-β (40-1) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β (40-1) peptide (Aβ (40-1)) is a peptide that contains the reverse sequence of Aβ (1-40) peptide. | ||||
| GC42937 | Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt) | - | >95.00% | |
Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. | ||||
| GC43650 | FAM-Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
FAM-Amyloid-β (1-40) peptide is a fluorescently labeled amyloid-β peptide. | ||||
| GC44986 | TAMRA-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
TAMRA-Amyloid-β (1-28) peptide is a fluorescently labeled peptide. | ||||
| GC44987 | TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt) | - | >95.00% | |
TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. | ||||
| GC45382 | Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
| ||||
| GC45465 | Glp-Amyloid-β (3-40) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
| GC46850 | Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
A neuropeptide with diverse biological activities | ||||
| GC46851 | Amyloid-β (1-42) Peptide (trifluoroacetate salt) | - | >95.00% | |
A 42-amino acid protein fragment of amyloid-β | ||||
| GC61988 | β-amyloid (12-28) (TFA) | - | >99.50% | |
| GP10049 | Amyloid Beta-Peptide (12-28) (human) | 107015-83-8 | >95.00% | |
Amyloid Beta-Peptide (12-28) (human) is a peptide fragment of amyloid beta protein (1-42) (Aβ (1-42)). | ||||
| GP10057 | Amyloid β-Peptide (10-20) (human) | 152286-31-2 | >98% | |
| GP10082 | Amyloid Beta-peptide (25-35) (human) | 131602-53-4 | >98.50% | |
Amyloid beta(Aβ)-peptide (25-35) (human) is an fragment of Alzheimer's Amyloid beta peptide which is commonly found in the brains of people with Alzheimer's disease (AD) and is a major component of Alzheimer's amyloid plaques. | ||||
| GP10083 | Beta-Amyloid (1-11) | 190436-05-6 | >98% | |
| GP10094 | Amyloid β-peptide (10-35), amide | - | >98% | |
| GP10097 | Amyloid β-Protein (1-15) | 183745-81-5 | >98% | |
| GP10118 | Amyloid Beta-Peptide (1-40) (human) | 131438-79-4 | >96.00% | |
Amyloid Beta-Peptide (1-40) (human) is the main component of senile plaque amyloid and is a physiological peptide present in the brain, cerebrospinal fluid (CSF), and plasma. | ||||