Amyloid Beta-Peptide (12-28) (human) |
Catalog No.GP10049 |
Amyloid Beta-Peptide (12-28) (human) is a peptide fragment of amyloid beta protein (1-42) (Aβ (1-42)).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 107015-83-8
Sample solution is provided at 25 µL, 10mM.
Amyloid Beta-Peptide (12-28) (human) is a peptide fragment of amyloid beta protein (1-42) (Aβ (1-42)) [1]. One of the neuropathological features of Alzheimer's disease (AD) is the presence of amyloid deposits in senile plaques and in blood vessel walls [2]. Amyloid Beta-Peptide (12-28) was used as an internal standard [1].
Amyloid Beta-Peptide (12-28) (human) could efficiently suppress the formation of the α7nAChR.Aβ (1-42) complex. Using human brain tissues and cells that overexpress either the α7 nicotinic acetylcholine receptor (α7nAChR) or amyloid precursor protein as the starting material, Aβ (1-42) and α7nAChR can be co-immunoprecipitated by the respective specific antibodies, suggesting that they are tightly associated [3].
References:
[1]. Wang R, Sweeney D, Gandy SE, Sisodia, SS (1996) The profile of soluble amyloid b protein in cultured cell media. Detection and quantificaiton of amyloid β protein and variants by immunoprecipitation-mass spectrometry. J Biol Chem 271:31894-31902.
[2]. Terry R. D., and Davies P.(1983) Aging of the Brain (Samuel, D., Algeri, S.,Gershon ,S., Grimm, V., and Toffano, G., eds) Vol. 22, pp. 47-59, Raven Press
[3]. Wang, H. Y. et al. β-Amyloid1-42 binds to α7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J. Biol. Chem. 275, 5626-5632 (2000).
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