GLPBio

PKA

PKA (protein kinase A), also known as cAMP-dependent protein kinase, has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.

Products Related to PKA(57)

  • GC15525 structure
    GC15525cGMP Dependent Kinase Inhibitor Peptide
    CAS: 82801-73-8
    Purity: >98.00%

    cGMP Dependent Kinase Inhibitor Peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM.

  • GC10428 structure
    GC10428Sp-5,6-dichloro-cBIMPS (sodium salt)
    CAS: 142439-96-1
    Purity: >98%

    PKA activator

  • GC10918 structure
    GC10918AT7867 dihydrochloride
    CAS: 1431697-86-7
    Purity: >99.00%

    A potent and orally bioavailable pan-Akt inhibitor

  • GC10941 structure
    GC10941cAMPS-Rp, triethylammonium salt
    CAS: 151837-09-1
    Purity: >99.00%

    cAMPS-Rp, triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist.

  • GC11362 structure
    GC11362K 252a
    CAS: 99533-80-9
    Purity: >98.00%

    A protein kinase inhibitor

  • GC11605 structure
    GC11605C-1
    CAS: 84468-24-6
    Purity: >99.50%

    C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor.

  • GC12297 structure
    GC12297AT7867
    CAS: 857531-00-1
    Purity: >98.00%

    Akt1/2/3 and p70S6K/PKA inhibitor

  • GC12799 structure
    GC12799H-8 (hydrochloride)
    CAS: 113276-94-1
    Purity: >98%

    H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor.

  • GC12824 structure
    GC12824Dibutyryl-cAMP, sodium salt
    CAS: 16980-89-5
    Purity: >99.00%

    Dibutyryl-cAMP, sodium salt, also known as Bucladesine, is a cell-permeable cyclic nucleotide analogue which mimics the action of endogenous cAMP and acts as a phosphodiesterase inhibitor.

  • GC13640 structure
    GC13640Kemptide
    CAS: 65189-71-1
    Purity: >96.50%

    substrate for cAMP-dependent protein kinase (PKA)

  • GC13869 structure
    GC13869Fasudil
    CAS: 103745-39-7
    Purity: >98.00%

    Fasudil (HA-1077; AT877) is a non-specific RhoA/ROCK inhibitor with a K i of 0.33μM and an IC 50 of 0.158μM for ROCK1, and IC 50 of 4.58μM, 12.30μM, and 1.650μM for ROCK2, PKA, PKC, and PKG, respectively.

  • GC14289 structure
    GC14289Fasudil (HA-1077) HCl
    CAS: 105628-07-7
    Purity: >98.00%

    Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator.

  • GC15299 structure
    GC15299Staurosporine(CGP 41251)
    CAS: 62996-74-1
    Purity: >99.50%

    Staurosporine, a small kinase inhibitor, is an alkaloid derived from the bacterium Streptomyces staurosporeus .

  • GC15352 structure
    GC153528-CPT-Cyclic AMP (sodium salt)
    CAS: 93882-12-3
    Purity: >98.00%

    8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA).

  • GC16678 structure
    GC16678UCN-02
    CAS: 121569-61-7
    Purity: >98%

    protein kinase C inhibitor

  • GC16929 structure
    GC169298-Bromo-cAMP, sodium salt
    CAS: 76939-46-3
    Purity: >98.00%

    8-Bromo-cAMP (8-Bromo-cAMP, sodium salt) is a cell-permeable cAMP analogue that acts as a CAMP-dependent protein kinase activator (PKA activator).

  • GC17255 structure
    GC17255Gliotoxin
    CAS: 67-99-2
    Purity: >98.00%

    Gliotoxin, an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi, is a specific inhibitor of 20S proteasomal chymotrypsin activity with an IC 50 of 10μM.

  • GC17346 structure
    GC17346KT 5823
    CAS: 126643-37-6
    Purity: >95.00%

    A protein kinase G inhibitor

  • GC17712 structure
    GC17712AT13148
    CAS: 1056901-62-2
    Purity: >99.50%

    Multi-AGC kinase inhibitor,ATP-competitive

  • GC19090 structure
    GC19090CCG215022
    CAS: 1813527-81-9
    Purity: >98.00%

    CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 uM, 0.38±0.06 uM and 3.9±1 uM for GRK2, GRK5 and GRK1, respectively.

  • GC19396 structure
    GC19396H 89
    CAS: 127243-85-0
    Purity: >98.00%

    A potent inhibitor of cyclic AMP-dependent protein kinase

  • GC30545 structure
    GC30545Malantide
    CAS: 86555-35-3
    Purity: >98.50%

    Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide is also an efficient substrate for PKC with a Km of 16 μM.

  • GC30857 structure
    GC30857Warangalone (Scandenolone)
    CAS: 4449-55-2
    Purity: >98.00%

    Warangalone (Scandenolone) is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively.

  • GC31525 structure
    GC31525CREBtide
    CAS: 149155-45-3
    Purity: >98.50%

    A PKA substrate