GLPBio

C-1

Catalog No.: GC11605Purity:>99.50%
COASDSData Sheet
C-1 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. C-1 also used as a ROCK inhibitor.

Products are for research use only. Not for human use. We do not sell to patients.

C-1
Cas No.: 84468-24-6
10mM (in 1mL DMSO)In Stock
$63.00
1
5mgIn Stock
$60.00
1
10mgIn Stock
$96.00
1
25mgIn Stock
$193.00
1
50mgIn Stock
$309.00
1
100mgIn Stock
$494.00
1
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Citations

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    187(9):2288-2304 (2024)
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Description

HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively[1].

HA-100 inhibits MLC-kinase and PKC competitively with respect to ATP, and the Ki values are 61 and 6.5 μM, respectively[1].

References:
[1]. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
84468-24-6
Chemical Name
5-(piperazin-1-ylsulfonyl)isoquinoline
SMILES
O=S(N1CCNCC1)(C2=CC=CC3=C2C=CN=C3)=O
Molecular Formula
C13H15N3O2S
Molecular Weight
277.34
Solubility
Soluble in DMSO
Storage
Store at RT
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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