Ferroptosis

Cycloheximide is an orally active antifungal antibiotic produced by Streptomyces griseus. Cycloheximide inhibits protein synthesis and RNA synthesis in vivo (IC 50 =532.5nM and 2880nM).

L-Glutamic acid is the main excitatory neurotransmitter in the mammalian central nervous system (CNS). L-Glutamic acid has two major types of receptors: ionotropic (NMDA-, AMPA-, and kainate-selective iGluRs) and metabotropic glutamate receptors. L-Glutamic acid induces excitotoxicity by activating the postsynaptic N-methyl-D-aspartate receptors, leading to neurodegenerative diseases.

Gingerenone A is an orally active Nrf2-Gpx4 activator with an EC 50 value of 24μM.

fat-soluble vitamin

broad-spectrum antifungal agent

Piperlongumine is a natural alkaloid compound extracted from Piper longum L. , which has multiple pharmacological activities, including anti-tumor, lipid metabolism regulation, anti-platelet aggregation and analgesic activities.

Ebselen is a selenoorganic compound with glutathione peroxidase-like activity and is an anti-inflammatory and antioxidant agent. Ebselen is an inhibitor of inositol monophosphatase (IMPase) with an IC 50 of 1.5μM.

Bay 11-7085 is an inhibitor of NF-κB activation and phosphorylation of IκBα with an IC 50 value of 10μM for IκBα.

Ferrostatin-1 (Fer-1) is a highly potent and selective ferroptosis inhibitor. Ferrostatin-1 inhibits Erastin-induced ferroptosis in HT-1080 cells (EC 50 =60nM).

U-73122 is a potent and selective phospholipase C (PLC) inhibitor with an IC 50 value of approximately 1-2.1µM. It also inhibits 5-lipoxygenase (5-LO).

Pifithrin-α(PFT-α) is a p53 inhibitor.Pifithrin-α widely used in neuroscience to block neuronal apoptotic cell death.Pifithrin-α is also a potent stimulant of aryl hydrocarbon receptor (AhR).

Simvastatin (Zocor) (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.

Dexrazoxane is a hydrophilic ring-closed analog of iron chelator ethylenediaminetetraacetic acid and also a strong inhibitor of topoisomerase II with IC 50 value of 10μM.

Artesunate is an antimalarial compound and an inhibitor of signal transducer and activator of transcription 3 (STAT-3) and membrane glutathione S-transferase (EXP1).

A stable inhibitor of p53

Necrostatin-1 is a novel small molecule inhibitor of necroptosis. Necrostatin-1 inhibits RIP1 kinase activity (EC 50 =182nM) through allosteric binding.

Ciclopirox ethanolamine (Ciclopirox ethanolamine) is a synthetic antifungal agent that can be used for superficial mycoses reseaech.

A PPARγ agonist

A PPARγ agonist

Bardoxolone methyl is an effective activator of the antioxidant and anti-inflammatory response mediated by nuclear factor erythroid 2-related factor 2 (Nrf2), and it is also an inhibitor of the NF-κB pathway.

Lovastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that impacts the mevalonate pathway, which has an IC 50 value of 77nM.