ADC Cytotoxin
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ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.
The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.
Products Related to ADC Cytotoxin(111)
- GC73858Glucocorticoid receptor agonist-4CAS: 2842165-72-2Purity: >99.00%
Glucocorticoid receptor agonist-4 (Compound Preparation 5) is a glucocorticoid receptor agonist that can be conjugated to TNF-α antibodies for the study of autoimmune and inflammatory diseases.
- GC73938PBD-monoamideCAS: 2093165-00-3Purity: >96.00%
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin.
- GC74118SJG-136 intermediate-1CAS: 232931-64-5Purity: >99.00%
SJG-136 intermediate-1 (compound 19) is an intermediate for synthesizing SJG-136.
- GC74122Taltobulin intermediate-4CAS: 187345-37-5Purity: >99.00%
Taltobulin intermediate-4 is an intermediate in the synthesis of Taltobulin.
- GC74127(R)-Exatecan Intermediate 1CAS: 110351-91-2Purity: >99.00%
(R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1.
- GC74132Exatecan Intermediate 5CAS: 143655-70-3Purity: >99.00%
Exatecan Intermediate 5 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research.
- GC74134Exatecan Intermediate 6CAS: 143655-58-7Purity: >98.00%
Exatecan Intermediate 6 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research.
- GC74135Exatecan Intermediate 7CAS: 182182-32-7Purity: >99.00%
Exatecan Intermediate 7 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research.
- GC74147TAM558 intermediate-5CAS: 1415659-15-2Purity: >95.00%
TAM558 intermediate-54 is an intermediate in the synthesis of TAM558.
- GC74652Exatecan Intermediate 2 hydrochlorideCAS: 2437603-23-9Purity: >99.00%
Exatecan Intermediate 2 drochloride (compound B) is an intermediate of Exatecan (DX-8951, ).
- GC74653Exatecan Intermediate 4CAS: 2436720-50-0
Exatecan Intermediate 4 (compound B) is an intermediate of Exatecan (DX-8951, ).
- GC74654Exatecan Intermediate 4 dihydrochloridePurity: >99.00%
Exatecan Intermediate 4 didrochloride is an intermediate of Exatecan (DX-8951, ).
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC73858 | Glucocorticoid receptor agonist-4 | 2842165-72-2 | >99.00% | |
Glucocorticoid receptor agonist-4 (Compound Preparation 5) is a glucocorticoid receptor agonist that can be conjugated to TNF-α antibodies for the study of autoimmune and inflammatory diseases. | ||||
| GC73938 | PBD-monoamide | 2093165-00-3 | >96.00% | |
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. | ||||
| GC74118 | SJG-136 intermediate-1 | 232931-64-5 | >99.00% | |
SJG-136 intermediate-1 (compound 19) is an intermediate for synthesizing SJG-136. | ||||
| GC74122 | Taltobulin intermediate-4 | 187345-37-5 | >99.00% | |
Taltobulin intermediate-4 is an intermediate in the synthesis of Taltobulin. | ||||
| GC74127 | (R)-Exatecan Intermediate 1 | 110351-91-2 | >99.00% | |
(R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1. | ||||
| GC74132 | Exatecan Intermediate 5 | 143655-70-3 | >99.00% | |
Exatecan Intermediate 5 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. | ||||
| GC74134 | Exatecan Intermediate 6 | 143655-58-7 | >98.00% | |
Exatecan Intermediate 6 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. | ||||
| GC74135 | Exatecan Intermediate 7 | 182182-32-7 | >99.00% | |
Exatecan Intermediate 7 is the intermediate of Exatecan And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. | ||||
| GC74147 | TAM558 intermediate-5 | 1415659-15-2 | >95.00% | |
TAM558 intermediate-54 is an intermediate in the synthesis of TAM558. | ||||
| GC74150 | Exatecan analog 36 | - | >98.00% | |
Exatecan analog 36 is a analog of Exatecan. | ||||
| GC74178 | Ac-Exatecan | 2922852-48-8 | >98.00% | |
Ac-Exatecan is acetylated Exatecan. | ||||
| GC74652 | Exatecan Intermediate 2 hydrochloride | 2437603-23-9 | >99.00% | |
Exatecan Intermediate 2 drochloride (compound B) is an intermediate of Exatecan (DX-8951, ). | ||||
| GC74653 | Exatecan Intermediate 4 | 2436720-50-0 | - | |
Exatecan Intermediate 4 (compound B) is an intermediate of Exatecan (DX-8951, ). | ||||
| GC74654 | Exatecan Intermediate 4 dihydrochloride | - | >99.00% | |
Exatecan Intermediate 4 didrochloride is an intermediate of Exatecan (DX-8951, ). | ||||
| GN10449 | SN-38 (NK012) | 86639-52-3 | >99.50% | |