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Home >> Signaling Pathways >> Antibody-drug Conjugate/ADC Related >> ADC Cytotoxin

ADC Cytotoxin

ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.

The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.

Targets for  ADC Cytotoxin

Products for  ADC Cytotoxin

  1. Cat.No. Product Name Information
  2. GC34955 (+)-CBI-CDPI1 (+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody drug conjugates (ADCs) toxin. (+)-CBI-CDPI1 Chemical Structure
  3. GC34956 (+)-CBI-CDPI2 (+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody drug conjugates (ADCs) toxin. (+)-CBI-CDPI2 Chemical Structure
  4. GC60421 (S)-Seco-Duocarmycin SA (S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates. (S)-Seco-Duocarmycin SA Chemical Structure
  5. GC35044 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features. 10-Deacetyl-7-xylosyl paclitaxel Chemical Structure
  6. GC14858 Aldoxorubicin An albumin-binding prodrug of doxorubicin Aldoxorubicin Chemical Structure
  7. GC61563 Aminohexylgeldanamycin Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities. Aminohexylgeldanamycin Chemical Structure
  8. GC11947 Ansamitocin P-3 A microtubule depolymerizing agent Ansamitocin P-3 Chemical Structure
  9. GC35429 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates. Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E Chemical Structure
  10. GC35430 Auristatin F Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC). Auristatin F Chemical Structure
  11. GC35574 C-11 C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines. C-11 Chemical Structure
  12. GC19086 Calicheamicin Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin Chemical Structure
  13. GC38016 Cyclooctyne-O-NHS ester Cyclooctyne-O-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Cyclooctyne-O-NHS ester Chemical Structure
  14. GC38631 Cyclooctyne-O-PFP ester Cyclooctyne-O-PFP ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Cyclooctyne-O-PFP ester Chemical Structure
  15. GC35797 D8-MMAD D8-MMAD Chemical Structure
  16. GC35798 D8-MMAF D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride. MMAF Hydrochloride, a potent tubulin polymerization inhibitor, is used as a antitumor agent and a cytotoxic component of antibody-drug conjugates (ADCs). D8-MMAF Chemical Structure
  17. GC35799 D8-MMAF hydrochloride D8-MMAF hydrochloride Chemical Structure
  18. GC11175 Daun02 Daun02 Chemical Structure
  19. GC12828 Daunorubicin

    DNA topoisomerase II inhibitor

     Daunorubicin Chemical Structure
  20. GC10354 Daunorubicin HCl Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin HCl Chemical Structure
  21. GC38538 DC0-NH2 DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component. DC0-NH2 Chemical Structure
  22. GC34185 DC1 DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer. DC1 Chemical Structure
  23. GC34190 DC1-SMe DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer. DC1-SMe Chemical Structure
  24. GC35817 DC41 DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. DC41 Chemical Structure
  25. GC35818 DC41-SMe DC41-SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. DC41-SMe Chemical Structure
  26. GC60143 DM3 DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs). DM3 Chemical Structure
  27. GC38355 DM3-SMe DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM. DM3-SMe Chemical Structure
  28. GC38468 DM4-SMe DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM. DM4-SMe Chemical Structure
  29. GC16273 Dolastatin 10 Antitumor agent Dolastatin 10 Chemical Structure
  30. GA21397 Dolastatin 15 Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED?? value of 2.4 ng/mL. Dolastatin 15 Chemical Structure
  31. GC17567 Doxorubicin (Adriamycin) HCl Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl Chemical Structure
  32. GC38774 DRF-1042 DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. DRF-1042 Chemical Structure
  33. GC35908 Duocarmycin A Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels. Duocarmycin A Chemical Structure
  34. GC38080 Duocarmycin Analog Duocarmycin Analog is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog Chemical Structure
  35. GC35909 Duocarmycin GA Duocarmycin GA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-drug resistant cell lines. Duocarmycin GA Chemical Structure
  36. GC35910 Duocarmycin MA Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines. Duocarmycin MA Chemical Structure
  37. GC35911 Duocarmycin MB Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB Chemical Structure
  38. GC35912 Duocarmycin SA Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro. Duocarmycin SA Chemical Structure
  39. GC32187 Duocarmycin TM Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA. Duocarmycin TM Chemical Structure
  40. GC32926 Dxd (Exatecan derivative) Dxd (Exatecan derivative) (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd (Exatecan derivative) Chemical Structure
  41. GC62212 Dxd-D5 Dxd-d5 (Exatecan-d5 derivative for ADC) is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) . Dxd-D5 Chemical Structure
  42. GC43882 Hygrolidin Hygrolidin is a macrocyclic lactone originally isolated from S. Hygrolidin Chemical Structure
  43. GC32895 Maytansinol (Ansamitocin P-0) Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and induces microtubule disassembly in vitro. Maytansinol (Ansamitocin P-0) Chemical Structure
  44. GC47620 Mensacarcin A bacterial metabolite with anticancer activity Mensacarcin Chemical Structure
  45. GC19244 Mertansine Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine Chemical Structure
  46. GC10405 Methotrexate

    Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations, the anti-phlogistic action of which is due to increased adenosine release at inflamed sites. 

     Methotrexate Chemical Structure
  47. GC61047 Methotrexate disodium Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium Chemical Structure
  48. GC15798 MMAD MMAD Chemical Structure
  49. GC63775 MMAD-d8 D8-MMAD is a deuterated form of MMAD, which is a microtubule disrupting agent. MMAD-d8 Chemical Structure
  50. GC10034 MMAF Anti-mitotic/anti-tubulin/antineoplastic agent MMAF Chemical Structure
  51. GC36633 MMAF Hydrochloride MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride Chemical Structure
  52. GC38397 MMAF sodium MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium Chemical Structure
  53. GC36634 MMAF-OMe MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-OMe Chemical Structure
  54. GC17276 Monomethyl auristatin E

    A potent antimitotic compound

     Monomethyl auristatin E Chemical Structure
  55. GC12511 Paclitaxel (Taxol)

    A potent mitotic inhibitor

     Paclitaxel (Taxol) Chemical Structure
  56. GC33136 PF-06380101 PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs. PF-06380101 Chemical Structure
  57. GC36941 PNU-159682 PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated?ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome drug resistance. PNU-159682 Chemical Structure
  58. GC66071 PNU-159682 carboxylic acid PNU-159682 carboxylic acid (compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. PNU-159682 carboxylic acid Chemical Structure
  59. GC61213 PROTAC BRD4 Degrader-5-CO-PEG3-N3 PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker. PROTAC BRD4 Degrader-5-CO-PEG3-N3 Chemical Structure
  60. GC44809 Rebeccamycin Rebeccamycin is an indolocarbazole antibiotic produced by S. Rebeccamycin Chemical Structure
  61. GC69863 SC209

    SC209 is an ADC cytotoxin derived from patent WO2021247798, used for synthesizing anti-EGFR antibody-active molecule conjugated ADCs. SC209 is a metabolite of STRO-002.

     SC209 Chemical Structure
  62. GC63184 Seco-DUBA Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA Chemical Structure
  63. GC38349 Seco-Duocarmycin SA Seco-Duocarmycin SA is a DNA alkylator, and is used as an ADC cytotoxin. Seco-Duocarmycin SA Chemical Structure
  64. GC38354 Seco-Duocarmycin TM Seco-Duocarmycin TM is a DNA alkylator agent belonging to Duocarmycins family that inhibits DNA synthesis. Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates (ADC). Seco-Duocarmycin TM Chemical Structure
  65. GC62691 SG3199 SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249). SG3199 Chemical Structure
  66. GC63189 SGD-1882 SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. SGD-1882 Chemical Structure
  67. GC34086 SJG-136 (NSC-694501) SJG-136 (NSC-694501) is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 (NSC-694501) has potent antitumor activity. SJG-136 (NSC-694501) Chemical Structure
  68. GN10449 SN-38 (NK012) SN-38 (NK012) Chemical Structure
  69. GC32753 Taltobulin (HTI-286) Taltobulin (HTI-286) (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin (HTI-286) inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin (HTI-286) Chemical Structure
  70. GC61314 Taltobulin hydrochloride Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin hydrochloride Chemical Structure
  71. GC34303 Taltobulin hydrochloride (HTI-286 hydrochloride) Taltobulin hydrochloride (HTI-286 hydrochloride) Chemical Structure
  72. GC34135 Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) Chemical Structure
  73. GC62288 Thailanstatin A Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC. Thailanstatin A Chemical Structure
  74. GC70043 Tomaymycin DM

    Tomaymycin DM is a DNA alkylating agent and a derivative of Tomaymycin. It is a monomer of PBD and can serve as an effective payload for tumor-targeting antibody-drug conjugates (ADCs).

     Tomaymycin DM Chemical Structure
  75. GC33155 Tubulysin A (TubA) Tubulysin A (TubA)(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysin A (TubA) Chemical Structure

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