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ADC Cytotoxin

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ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.

The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.

Products Related to ADC Cytotoxin(111)

  • GC34190 structure
    GC34190DC1-SMe
    CAS: 501666-85-9
    Purity: >98.00%

    DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

  • GC34303 structure
    GC34303Taltobulin hydrochloride (HTI-286 hydrochloride)
    Purity: >98%
  • GC34955 structure
    GC34955(+)-CBI-CDPI1
    CAS: 128300-14-1
    Purity: >98%

    (+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody drug conjugates (ADCs) toxin.

  • GC34956 structure
    GC34956(+)-CBI-CDPI2
    CAS: 128300-15-2
    Purity: >98%

    (+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody drug conjugates (ADCs) toxin.

  • GC35044 structure
    GC3504410-Deacetyl-7-xylosyl paclitaxel
    CAS: 90332-63-1
    Purity: >98.00%

    10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

  • GC35429 structure
    GC35429Auristatin E
    CAS: 160800-57-7
    Purity: >99.00%

    Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates. Auristatin E inhibits cell division by blocking the polymerisation of tubulin.

  • GC35430 structure
    GC35430Auristatin F
    CAS: 163768-50-1
    Purity: >99.00%

    Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

  • GC35574 structure
    GC35574C-11
    CAS: 2007965-97-9
    Purity: >98%

    C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines.

  • GC35797 structure
    GC35797D8-MMAD
    Purity: >98%
  • GC35798 structure
    GC35798D8-MMAF
    Purity: >98%

    D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride. MMAF Hydrochloride, a potent tubulin polymerization inhibitor, is used as a antitumor agent and a cytotoxic component of antibody-drug conjugates (ADCs).

  • GC35799 structure
    GC35799D8-MMAF hydrochloride
    Purity: >98%
  • GC35817 structure
    GC35817DC41
    CAS: 1354787-69-1
    Purity: >98%

    DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.

  • GC35818 structure
    GC35818DC41-SMe
    CAS: 1354787-71-5
    Purity: >98%

    DC41-SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.

  • GC35908 structure
    GC35908Duocarmycin A
    CAS: 118292-34-5
    Purity: >98%

    Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels.

  • GC35909 structure
    GC35909Duocarmycin GA
    CAS: 1613286-59-1
    Purity: >98%

    Duocarmycin GA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-drug resistant cell lines.

  • GC35910 structure
    GC35910Duocarmycin MA
    CAS: 1613286-57-9
    Purity: >98%

    Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines.

  • GC35911 structure
    GC35911Duocarmycin MB
    CAS: 1613286-58-0
    Purity: >98%

    Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-drug resistant cell lines.

  • GC35912 structure
    GC35912Duocarmycin SA
    CAS: 130288-24-3
    Purity: >98%

    Duocarmycin SA is a potent antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.

  • GC36633 structure
    GC36633MMAF Hydrochloride
    CAS: 1415246-68-2
    Purity: >99.50%

    MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A.

  • GC36634 structure
    GC36634MMAF-OMe
    CAS: 863971-12-4
    Purity: >98%

    MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.

  • GC36941 structure
    GC36941PNU-159682
    CAS: 202350-68-3
    Purity: >98%

    PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated?ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome drug resistance.

  • GC38016 structure
    GC38016Cyclooctyne-O-NHS ester
    CAS: 1425803-45-7
    Purity: >98.00%

    Cyclooctyne-O-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

  • GC38080 structure
    GC38080Duocarmycin Analog
    CAS: 372954-15-9
    Purity: >98%

    Duocarmycin Analog is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin.

  • GC38349 structure
    GC38349Seco-Duocarmycin SA
    CAS: 144667-38-9
    Purity: >98%

    Seco-Duocarmycin SA is a DNA alkylator, and is used as an ADC cytotoxin.