ADC Cytotoxin

Exatecan Intermediate 2 (compound B) is an intermediate compound in the production of Exatecan (DX-8951), which is an anticancer agent and belongs to the camptothecin analogs. It interferes with tumor cell proliferation and division by interacting with DNA, thereby inhibiting tumor growth. Exatecan is mainly used for research on various cancers such as ovarian cancer, lung cancer, and breast cancer.

Inebilizumab is a monoclonal antibody (mAb) that targets CD19 and enhances antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab is being studied for use in multiple sclerosis and neuromyelitis optica spectrum disorder.

Maytansinoid B is an ADC cytotoxin that can form Antibody-Drug Conjugates (ADCs) when coupled with antibodies. Maytansinoids are known anti-mitotic agents that bind to tubulin and inhibit microtubule assembly. Maytansinoids can induce cell cycle arrest at G2/M phase, thereby inducing apoptosis.

SC209 is an ADC cytotoxin derived from patent WO2021247798, used for synthesizing anti-EGFR antibody-active molecule conjugated ADCs. SC209 is a metabolite of STRO-002.

Tomaymycin DM is a DNA alkylating agent and a derivative of Tomaymycin. It is a monomer of PBD and can serve as an effective payload for tumor-targeting antibody-drug conjugates (ADCs).

Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC50 value of 6.6 nM.

S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme.

Glucocorticoid receptor agonist-3 (Preparation 6) is a glucocorticoid receptor agonist.

7-Aminometl-10-metl-11-fluoro camptothecin is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminometl-10-metl-11-fluoro camptothecin.

7-Aminometl-10-metl-11-fluoro camptothecin TFA is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminometl-10-metl-11-fluoro camptothecin.

7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).

(1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) is an isomer of Exatecan mesylate.

(1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate.

TAM470 is a novel cytolysin, inhibiting tubulin polymerization and microtubule depolymerization.

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT drochloride is a topoisomerase I inhibitor, which can be delivered to cells through conjugated antibody targeting, and has good ADC activity in vivo and in vitro.

Decyclohexanamine-Exatecan is a Camptothecin derivative, compound a, extracted from patent WO2020219287 A1.

MMAF-OtBu (Example 2) is a modified MMAF.

7-droxyetl carbamate-(10Me-11F-Camptothecin) is a Camptothecin analogue.

Cyclopropaneacetamide-Exatecan (Compound 2-A) is an ADC Cytotoxin and an Exatecan analogue.

(αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent.

NH2-metlpropanamide-Exatecan TFA is a metlpropanamide-modified Exatecan , which is the common ADC Cytotoxin used in the synthesis of ADC.

7-droxymetl-10,11-MDCPT-d5 is deuterium labeled 7-droxymetl-10,11-MDCPT, which is a is a payload that can be used for ADC synthesis.

Exatecan-metlacetamide-OH (compound 6) is a Exatecan derivative with anticancer effects.

FL118-14-Propanol is a FL118 derivative.