COX

SC58451 is a potent and selective Cox-2 inhibitor.

Naproxen etemesil (LT-NS 001) is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed.

Pamicogrel (KBT3022) (KBT3022) is a cyclooxygenase (COX) inhibitor.

Catechin ((+)-Catechin) ((+)-Catechin ((+)-Catechin)) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

(-)-Catechin gallate ((-)-Catechin 3-gallate) is a minor constituent in green tea catechins. (-)-Catechin gallate ((-)-Catechin 3-gallate) inhibits the activity of COX-1 and COX-2 enzymes.

Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC 50 values of 10.08, 12.62, and 16.43μM, respectively.

Inulicin (1-O-Acetylbritannilactone) (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK.

Propyphenazone (4-Isopropylantipyrine) is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone (4-Isopropylantipyrine)-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

FR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC50 value of 17 nM.

Nitroflurbiprofen (HCT 1206) is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities.

[10]-Shogaol is an antioxidant from Zingiber officinale for human skin cell growth and a migration enhancer. [10]-Shogaol inhibits COX-2 with an IC50 of 7.5 μM and has antiproliferation activity.

[8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5 μM) and inhibits COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells.

Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, COX-1 and COX-2 enzymes and anti-inflammatory activity.

Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib.

A NSAID and COX-2 inhibitor

Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM.

Indobufen is a platelet aggregation inhibitor.

Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties.

An internal standard for the quantification of nepafenac

Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins.