COX
COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.
Products for COX
- Cat.No. Product Name Information
- GC63267 α-Chaconine α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level.
- GC40262 α-Humulene α-Humulene is a sesquiterpene that has been found in C.
- GC10873 α-Spinasterol TRPV1 antagonist
- GC41623 β-Elemonic Acid β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity.
- GC41658 (±)-2-hydroxy Ibuprofen (±)-2-hydroxy Ibuprofen is a metabolite of ibuprofen .
- GC46290 (±)-Ibuprofen-d3 An Analytical Reference Standard
- GC49515 (±)-Ibuprofen-d3 (sodium salt) An internal standard for the quantification of (±)-ibuprofen
- GC45278 (±)-Ketoprofen-d3
- GN10605 (+)-Catechin hydrate
- GC11049 (+/-)-Sulfinpyrazone platelet COX inhibitor
- GC40842 (-)-Catechin
- GC32957 (-)-Catechin gallate ((-)-Catechin 3-gallate) (-)-Catechin gallate ((-)-Catechin 3-gallate) is a minor constituent in green tea catechins. (-)-Catechin gallate ((-)-Catechin 3-gallate) inhibits the activity of COX-1 and COX-2 enzymes.
- GC10603 (-)-epicatechin gallate major catechin in green tea
- GC13114 (S)-(+)-Ibuprofen COX inhibitor
- GC64804 (S)-(+)-Ibuprofen D3 (S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen.
- GC18022 (S)-Flurbiprofen inhibitors of COX-1 and COX-2
- GC15977 (S)-Ketoprofen COX-1 and COX-2 inhibitor
- GC41389 (S)-Ketorolac (S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively).
- GC14820 (S)-Naproxen (S)-Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
- GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen
- GC41761 1-(6-Methoxy-2-naphthyl)ethanol 1-(6-Methoxy-2-naphthyl)ethanol is a potential impurity in commercial preparations of naproxen.
- GC60447 1-Hydroxy-ibuprofen 1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P.
- GC49366 1-Salicylate Glucuronide A metabolite of salicylic acid and aspirin
- GC42201 3,3'-Diiodo-L-thyronine 3,3'-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3'-T2.
- GC39307 4-Methylamino antipyrine 4-Methylamino antipyrine is an active metabolite of Metamizole.
- GC60523 4-Methylamino antipyrine hydrochloride An active metabolite of metamizole
- GC49119 5-hydroxy Flunixin A metabolite of flunixin
- GC49315 5-hydroxy Indomethacin A metabolite of indomethacin
- GC49183 6-hydroxy Etodolac A metabolite of etodolac
- GC16153 6-methoxy Naphthalene Acetic Acid competitive, non-selective COX inhibitor
- GC15338 8,11,14-Eicosatriynoic Acid A Cox, 12-LO, and 5-LO inhibitor
- GC14302 9,12-Octadecadiynoic Acid 9,12-Octadecadiynoic Acid (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor.
- GC15902 Aceclofenac non-steroidal anti-inflammatory drug
- GC42691 Aceclofenac ethyl ester A potential impurity found in commercial preparations of aceclofenac
- GC42692 Aceclofenac methyl ester A potential impurity in commercial preparations of aceclofenac
- GC10454 Acemetacin COX inhibitor
-
GC12917
Acetaminophen
A COX inhibitor
- GC64137 Acetaminophen-d3
- GC46781 Acetaminophen-d4 A Certified Reference Material
- GC31693 Adelmidrol Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ.
- GC62830 AG-024322 AG-024322 is a potent ATP-competitive pan-CDK inhibitor against cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range. AG-024322 displays broad-spectrum anti-tumor activity and clear target modulation?in vivo. AG-024322 induces cell apoptosis.
- GC61689 Alminoprofen Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class.
- GC14740 Amfenac Sodium Monohydrate Amfenac Sodium Monohydrate is a COX-2 inhibitor.
- GC14104 Ampiroxicam COX inhibitor
- GC33484 Ampyrone (4-Aminoantipyrine)
- GN10685 Anemarsaponin B
- GC17776 Asaraldehyde COX inhibitor
- GC15706 Aspirin (Acetylsalicylic acid) A non-selective, irreversible COX inhibitor
- GC63683 Aspirin-d3
- GC42859 Aspirin-d4 Aspirin-d4 is intended for use as an internal standard for the quantification of aspirin by GC- or LC-MS.
- GC18133 ATB-346 ATB-346 (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2).
- GC35493 Benzoylgomisin O Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, COX-1 and COX-2 enzymes and anti-inflammatory activity.
- GC13039 Bromfenac Sodium COX inhibitor
- GC15410 Bufexamac COX inhibitor
- GN10080 Byakangelicol
- GC40352 Cafestol Cafestol is a natural diterpene which is abundant in unfiltered coffee.
- GC17341 Carprofen COX inhibitor
- GC32841 Catechin ((+)-Catechin) Catechin ((+)-Catechin) ((+)-Catechin ((+)-Catechin)) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
-
GC43149
CAY10404
Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.
- GC18427 CAY10452 CAY10452 (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities.
- GC14475 Celecoxib Selective cyclooxygenase-2 (COX-2) inhibitor
- GC49152 Celecoxib Carboxylic Acid An inactive metabolite of celecoxib
- GC47070 Celecoxib-d7 An internal standard for the quantification of celecoxib
- GC31707 Chebulagic acid Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis.
- GC18369 Cimicoxib A selective inhibitor of COX-2
- GC31749 Columbin A diterpenoid furanolactone with diverse biological activities
- GN10338 Compound K
- GC31962 COX-2-IN-1 COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM.
- GC68016 COX-2-IN-6
- GC31967 COX/5-LO-IN-1 COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states.
- GC32030 COX2-IN-1
- GC38224 Crocin II
- GN10430 D-(-)-Salicin
- GC38184 Dehydrodiisoeugenol
- GC38431 Dehydroevodiamine Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes.
- GC16077 Deracoxib Selective COX-2 inhibitor
- GC64136 Desmethyl Naproxen-d3 Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen.
-
GC11090
Diclofenac
non-selective COX inhibitor
- GC47212 Diclofenac amide A prodrug form of diclofenac
- GC14587 Diclofenac Diethylamine non-selective COX inhibitor
- GC43447 Diclofenac methyl ester Diclofenac methyl ester is a hydrophobic prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac.
- GC14622 Diclofenac Potassium nonsteroidal anti-inflammatory drug
-
GC14261
Diclofenac Sodium
COX inhibitor
- GC47213 Diclofenac-d4 An internal standard for the quantification of diclofenac
-
GC12591
Diflunisal
COX inhibitor, nonsteroidal anti-inflammatory drug (NSAID)
- GC12156 DuP 697 cyclooxygenase-2 inhibitor
- GC38015 Eicosatetraynoic acid A nonspecific inhibitor of cyclooxygenases and lipoxygenases
- GC12229 Eicosatetraynoic Acid nonspecific inhibitor of cyclooxygenases and lipoxygenases
- GC47287 Eltenac A non-selective COX inhibitor
- GC63804 Enflicoxib Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2).
- GN10004 EsculentosideA
- GC38678 Ethyl Caffeate Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa.
- GC43635 Ethyl p-methoxycinnamate Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects.
- GC16662 Etodolac COX-2 inhibitor
- GC49156 Etodolac Acyl Glucuronide A phase II metabolite of etodolac
- GC10429 Etoricoxib A selective COX-2 inhibitor
- GC36014 Etoricoxib D4 Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib.
- GC13746 Fenbufen COX inhibitor, non-steroidal anti-inflammatory drug
- GC14584 Fenofibric acid ppar inhibitor, lipid-lowering agent
- GC17882 Fenoprofen Calcium nonsteroidal, anti-inflammatory antiarthritic agent