HIF

Deoxyshikonin is a natural product isolated from Lithospermum erythrorhizon Sieb with antitumor activity.

An inhibitor of HIF-1 signaling

Tiopronin is an antioxidant that has diverse biological activities.

Gramicidin A is a linear pentapeptide antibiotic produced by B. brevis .

PRLX-93936 is an analog of erastin that has antitumor activity.

Oroxylin A is an active flavonoid with anti-inflammatory, anti-bacterial, anti-viral, and anti-cancer properties.

Amifostine (hydrate) is a broad-spectrum cytoprotective agent primarily used to reduce the toxicity of chemotherapy or radiotherapy on normal tissues.

An internal standard for the quantification of tiopronin

An internal standard for the quantification of roxadustat

High affinity and selective HIF-2α inhibitor

Selective HIF-1 dimerization inhibitor

A HIF α-subunit inhibitor

Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia.

Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds.

Verucopeptin is a potent?HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity?by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR)?cancers and can be used for cancer research.

1,4-DPCA ethyl ester is the ethyl ester of 1,4-DPCA and can inhibit factor inhibiting HIF (FIH).

Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects.

Acriflavine hydrochloride (Acriflavinium chloride hydrochloride) is a fluorescent acridine dye that can be used to label nucleic acid.

Moracin O is a hypoxia-inducible factor (HIF-1) inhibitor isolated from Morus alba Linn., exhibiting significant anti-inflammatory and antioxidant activities.

HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent.

HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor extracted from patent WO2015035223A1, Compound 232, has an IC50 of 16 nM in scintillation proximity assay (SPA).

HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing.

Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2).

TRC160334 is a hypoxia-inducible factor (HIF) hydroxylase inhibitor.