HIF
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Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.
Products Related to HIF(118)
- GC74310Cyclo(CKLIIF) TFAPurity: >97.00%
Cyclo CKLIIF is a dual inhibitor for poxia inducible factor (HIF) 1 and 2, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 2.6 and 2.2 μM, respectively.
- GC79669PHD-1-IN-4CAS: 2009343-19-3Purity: >99.50%
PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] .
- GC79816CryptolepineCAS: 480-26-2Purity: >98%
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.
- GC81027PROTAC HIF-1α degrader-2CAS: 3095636-64-6Purity: >98%
PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex.
- GC815842-Amino-2-deoxy-D-glucopyranoseCAS: 90-77-7Purity: >98.00%
2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine.
- GC81602Glucosamine sulfate potassium chlorideCAS: 1296149-08-0Purity: >98.00%
Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.
- GN10308Chlorogenic acidCAS: 327-97-9Purity: >98.00%
Chlorogenic acid is a potent neuroprotective agent and also has antiviral,antifungal antioxidant and antitumor properties. CGA is also involved in regulating glucose and lipid metabolism and improving insulin sensitivity.
- GN10452PaeoniflorinCAS: 23180-57-6Purity: >98.00%
Paeoniflorin is a pinane monoterpene glycoside extracted from the roots of Paeonia plants of the Ranunculaceae family, possessing multiple biological activities.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC73945 | DYB-03 | 2982792-85-6 | >99.00% | |
DYB-03 is an oral active HIF-1α/EZH2 inhibitor. | ||||
| GC74310 | Cyclo(CKLIIF) TFA | - | >97.00% | |
Cyclo CKLIIF is a dual inhibitor for poxia inducible factor (HIF) 1 and 2, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 2.6 and 2.2 μM, respectively. | ||||
| GC78962 | MS1129 | - | >98% | |
MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins. | ||||
| GC79574 | mCPX | 1351572-56-9 | >98% | |
mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX). | ||||
| GC79669 | PHD-1-IN-4 | 2009343-19-3 | >99.50% | |
PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC 50 of 0.074 μM [1] . | ||||
| GC79670 | ZG-2686 | 1795110-22-3 | >98% | |
ZG-2686 is a potent and selective HIF-2α agonist with an EC 50 of 0.25 µM. | ||||
| GC79671 | HIF-IN-2 | 1040535-05-4 | >95.00% | |
HIF-IN-2 is a HIF/HIF prolyl hydroxylase inhibitor. | ||||
| GC79816 | Cryptolepine | 480-26-2 | >98% | |
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. | ||||
| GC80483 | IOX2-NH2 | 931400-77-0 | >98.00% | |
IOX2 -NH2 (example 115) is a derivative of IOX2. | ||||
| GC80928 | NP1192 | 2966791-41-1 | >99.00% | |
NP1192 is a potent, selective PROTAC NAT10 degrader. | ||||
| GC81027 | PROTAC HIF-1α degrader-2 | 3095636-64-6 | >98% | |
PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex. | ||||
| GC81031 | NEO-811 | 3084635-77-5 | >98% | |
NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader. | ||||
| GC81447 | ALDOA-IN-1 | - | >98.00% | |
ALDOA-IN-1 is an aldolase A (ALDOA) inhibitor. | ||||
| GC81584 | 2-Amino-2-deoxy-D-glucopyranose | 90-77-7 | >98.00% | |
2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine. | ||||
| GC81595 | BCS12 | 329719-71-3 | >99.50% | |
BCS12 is a CAIX inhibitor. | ||||
| GC81602 | Glucosamine sulfate potassium chloride | 1296149-08-0 | >98.00% | |
Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. | ||||
| GC81639 | SH-26 | - | >98% | |
SH-26 is a PHD1 PROTAC degrader with DC 50 s of 1.06 μM, 4.16 μM and 4.91 μM in MDA-MB-231, HepG2 and HEK-293T cells, respectively. | ||||
| GC91083 | Tiopronin-Cysteine Disulfide | 77591-18-5 | >95.00% | |
A metabolite of tiopronin | ||||
| GN10308 | Chlorogenic acid | 327-97-9 | >98.00% | |
Chlorogenic acid is a potent neuroprotective agent and also has antiviral,antifungal antioxidant and antitumor properties. CGA is also involved in regulating glucose and lipid metabolism and improving insulin sensitivity. | ||||
| GN10452 | Paeoniflorin | 23180-57-6 | >98.00% | |
Paeoniflorin is a pinane monoterpene glycoside extracted from the roots of Paeonia plants of the Ranunculaceae family, possessing multiple biological activities. | ||||
| GN10518 | Chitosamine hydrochloride | 66-84-2 | >98.00% | |
| GN10669 | Glucosamine sulfate | 29031-19-4 | >98.00% | |