HIF

Glucosamine (D-Glucosamine) (D-Glucosamine (D-Glucosamine)) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.

Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.

HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay.

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor

Acriflavine is a fluorescent dye for labeling high molecular weight RNA.

An interferon-inducing antiviral agent

An inhibitor of HIF-PH

PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM.

LW6 is a hypoxia-inducing factor 1(HIF) inhibitor, which effectively inhibits HIF-1α accumulation by degrading HIF-1α, but does not affect HIF-1A mRNA level during hypoxia.

A HIF-1 inhibitor

THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.

IDF-11774 is an orally administered HIF-1α inhibitor, with an IC 50 value of 3.65μM.

EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer.

ENMD-119 (ENMD 1198) (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-119 (ENMD 1198) is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization.

AFP464 (NSC710464 free base), is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

Enarodustat (JTZ-951) is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM.

GN44028 is a hypoxia-inducible factor (HIF)-1α inhibitor with an IC₅₀ value of 14nM.

Acetylarenobufagin is a steroidal hypoxia inducible factor-1 (HIF-I) modulator.

PT2977 is an orally active and selective HIF-2α inhibitor with an IC 50 of 9nM.

A potent and specific HIF-2α inhibitor

TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia.

VCE-004.8 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist.

ZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 ?M.