Sirtuin

CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 ?M).

ADTL-SA1215 is a first-in-class specific small-molecule activator of SIRT3 that modulates autophagy in triple negative breast cancer.

Et-29 is a potent and selective SIRT5 inhibitor (Ki=40 nM).

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.

SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues.

Sirtuin modulator 2 (Compound 132) is a sirtuin modulator with an ED50 equal or less than 50 μM.

MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM.

SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.

CrBKA is a weakly active fluorescent small molecule substrate of SIRT6.

E1231 is an orally effective activator of Sirtuin 1 (SIRT1) with an EC50 of 0.83 μM, which can regulate cholesterol and lipid metabolism. E1231 interacts with both SIRT1 and liver X receptor-α (LXRα) and increases the expression of ATP-binding cassette transporter A1 (ABCA1). E1231 also reduces the formation of atherosclerotic plaques in ApoE-/- mouse models. E1231 can be used for research on diseases related to cholesterol and lipid disorders.

SIRT1-IN-2 (compound 3h) is an effective and selective inhibitor of SIRT1 (Silent Information Regulator Factor 1), with an IC50 of 1.6 μM.

SIRT5 inhibitor 3 (compound 46) is an effective and competitive inhibitor of SIRT5, with an IC50 of 5.9 μM. It can inhibit the deacetylation activity of SIRT5. SIRT5 inhibitor 3 can be used for research on cancer and neurodegenerative diseases.

SRT 1720 dihydrochloride is a selective and orally active SIRT1 activator with an EC50 of 0.10 μM, showing weaker effects on SIRT2 and SIRT3.

Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 0.55 μM for inhibiting the methyltransferase activity.

Z26395438 (compound 1) is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM.

Nicotinamide-13C6 is the 13C-labeled Nicotinamide.

Fisetin quarterhydrate is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector.

SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM).

RK-9123016 is a potent inhibitor of SIRT2.

Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases.

2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3), with a K D value of 2.756μM.

MC3138 is a selective SIRT5 activator.