Sirtuin

3-TYP is an orally active SIRT3 inhibitor (IC 50 =16nM) and also inhibits SIRT1 (IC 50 =88nM) and SIRT2 (IC 50 =92nM).

A SIRT1 activator

SIRT5 inhibitor is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.

SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.

SIRT2 Inhibitor II (AK-1) is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.

OSS_128167 is a potent selective silencing regulatory protein 6 (SIRT6) inhibitor with an IC 50 of 89 μM.

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).

Dihydrocoumarin (Hydrocoumarin) is a compound found in Melilotus officinalis. Dihydrocoumarin (Hydrocoumarin) is a yeast Sir2p inhibitor. Dihydrocoumarin (Hydrocoumarin) also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM.

UBCS039 is a synthetic specific activator of SIRT6, with EC 50 value of 38μM.

Nicotinamide riboside chloride, a new form of vitamin B 3 supplement, has also been shown to be an NAD + precursor that is orally available and can roughly double the level of NAD + in mammalian cells.

SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.

Tenovin-6 Hydrochloride, an analog of Tenovin-1, is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH).

A selective SIRT2 inhibitor

Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots.

Ganoderic acid D is an oxygenated triterpenoid that has been found in G.

Nicotinamide riboside is a vitamin B3/NAD + precursor. Nicotinamide riboside can be converted to NMN and ultimately to NAD + through pathways such as nicotinamide riboside kinase, elevating intracellular NAD + levels, activating SIRTs and improving mitochondrial function.

Gardenia yellow is a commonly used natural food coloring material with excellent water solubility properties.

SIRT7 inhibitor 97491 is a potent SIRT 7 inhibitor that reduces the deacetylase activity of SIRT7 in a dose-dependent manner with an IC50 of 325 nM.

SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively).

7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry.