Sirtuin

Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

Products Related to Sirtuin(80)

GC79057 BF-175
CAS: 1333375-02-2
Purity: >98%
BF-175 is a selective SIRT1 agonist.
GC80333 Ac-QPKK(Ac)-AMC acetate
Purity: >99.00%
Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) [1] .
GC81628 Nicotinamide- 13 C, 15 N
Purity: >98.50%
Nicotinamide - 13 C, 15 N (Niacinamide- 13 C, 15 N) is the 13 C- and 15 N-labeled Nicotinamide.
GN10030 Fisetin
CAS: 528-48-3
Purity: >98.00%
Fisetin is a natural flavonol found in many fruits and vegetables with multiple biological activities.
GN10347 Nicotinamide (Vitamin B3)
CAS: 98-92-0
Purity: >99.50%
Nicotinamide (Vitamin B3) is an amide derivative of vitamin B3 that can inhibit the activity of SIRT1 (IC 50 : 50-180 μM) and SIRT2 (IC 50 : 2 μM). Nicotinamide can also increase the levels of NAD + , ATP, and ROS in cells .
GN10413 Agrimol B
CAS: 55576-66-4
Purity: >99.50%
GN10473 Ginkgolide C
CAS: 15291-76-6
Purity: >98.00%
GC10676 AK-7
CAS: 420831-40-9
Purity: >99.50%
AK-7 is a cell-permeable and brain-permeable selective SIRT2 inhibitor (IC 50 =15.5μM).

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC79057	BF-175	1333375-02-2	>98%
GC79057	BF-175 is a selective SIRT1 agonist.
GC80333	Ac-QPKK(Ac)-AMC acetate	-	>99.00%
GC80333	Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) [1] .
GC81628	Nicotinamide- 13 C, 15 N	-	>98.50%
GC81628	Nicotinamide - 13 C, 15 N (Niacinamide- 13 C, 15 N) is the 13 C- and 15 N-labeled Nicotinamide.
GN10030	Fisetin	528-48-3	>98.00%
GN10030	Fisetin is a natural flavonol found in many fruits and vegetables with multiple biological activities.
GN10347	Nicotinamide (Vitamin B3)	98-92-0	>99.50%
GN10347	Nicotinamide (Vitamin B3) is an amide derivative of vitamin B3 that can inhibit the activity of SIRT1 (IC 50 : 50-180 μM) and SIRT2 (IC 50 : 2 μM). Nicotinamide can also increase the levels of NAD + , ATP, and ROS in cells .
GN10413	Agrimol B	55576-66-4	>99.50%
GN10473	Ginkgolide C	15291-76-6	>98.00%
GC10676	AK-7	420831-40-9	>99.50%
GC10676	AK-7 is a cell-permeable and brain-permeable selective SIRT2 inhibitor (IC 50 =15.5μM).