Home>>Signaling Pathways>> GPCR/G protein>> Adrenergic Receptor>>Fenmetozole Tosylate

Fenmetozole Tosylate

Catalog No.GC31271

Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, and acts as an antidepressant drug.

Products are for research use only. Not for human use. We do not sell to patients.

Fenmetozole Tosylate Chemical Structure

Cas No.: 83474-08-2

Size Price Stock Qty
1mg
$276.00
In stock
5mg
$552.00
In stock
10mg
$937.00
In stock
20mg
$1,655.00
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com


Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, and acts as an antidepressant drug.

Fenmetozole acts as an antagonist of α2-adrenergic receptor[3].

In mice, fenmetozole antagonizes both the ethanol induced increase in locomotor activity at 2.0 g/kg and the decrease caused by 4.0 g/kg. Moreover, fenmetozole attenuates the ethanol-induced reduction in cerebellar cyclic guanosine monophosphate content, but it significantly elevates cGMP levels in this tissue. Fenmetozole does not change ethanol induced increases in punished drinking in a conflict test, but when given at a high dose, fenmetozole decreases both punished and unpunished responding. Fenmetozole fails to precipitate ethanol withdrawal-like reactions when it is given to physically-dependent, intoxicated rats. Fenmetozole (15-30 g/kg) reduces ethanol-induced impairment of the aerial righting reflex without altering blood or brain ethanol content[1]. Fenmetozole alone has no ffect on punished drinking and does not alter ethanol action in the paradigm except at the highest dose tested (30 mg/kg) in rats[2].

[1]. Frye GD, et al. An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function. Psychopharmacology (Berl). 1980;69(2):149-55. [2]. Vogel RA, et al. Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex. Alcohol Clin Exp Res. 1981 Summer;5(3):386-92. [3]. Stillings MR, et al. Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists. J Med Chem. 1986 Sep;29(9):1780-3.

Reviews

Review for Fenmetozole Tosylate

Average Rating: 5 ★★★★★ (Based on Reviews and 34 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for Fenmetozole Tosylate

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.