Cannabinoid Receptor

Pregnenolone monosulfate is a key precursor to various steroid hormones, including steroid hormones, and possesses multiple biological functions.

Taranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant.

Taranabant racemate (MK-0364 racemate) is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor extracted from patent WO 2004048317 A1.

VCE-004.8 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist.

WIN 55,212-2 Mesylate is a potent aminoalkylindole cannabinoid (CB) receptor agonist with K i values of 62.3nM and 3.3nM for human recombinant CB1 and CB2 receptors, respectively.

TM38837 is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist.

Pregnenolone sulfate (sodium salt), a neuroactive metabolite of pregnenolone, exhibits the IC 50 value of 26±2μmol/L for the aminobutyric acid type A receptor (GABA A R) and the IC 50 value of 18±3μmol/L for GABA A R without the γ subunit.

Voacamine is an alkaloid originally isolated from Voacanga that has diverse biological activities.

Negative allosteric modulator of CB1 receptors

Highly potent and selective CB2 inverse agonist

Potent and selective CB2 partial agonist; orally biovailable

Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective

Selective GPR18 antagonist

Ec2la is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator.

BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist, with Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively.

AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist.

AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively.

(Rac)-MRI-1867 ((Rac)-MRI-1867, compound 6b) is a cannabinoid receptor type 1 (CB1R)/iNOS antagonist, with a Ki of 5.7 nM for CB1R.

RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay.

Tedalinab (GRC-10693) is a potent, orally active, and selective cannabinoid receptor 2 (CB2) agonist.

CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC50 value of 5.7. CB1 agonist 1 can be used for the research of brain disorders.

RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. RVD-Hpα TFA increases intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA also high affinity CB2 positive allosteric modulator (Ki=50 nM).