Prostaglandin Receptor

Pizuglanstat (compound 3) is a prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthases (H-PGDS).

Aganepag isopropyl (AGN-210961) is an EP2 agonist.

Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker.

Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM.

BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC50 of 15.3 nM for human EP4-R.

EP2 receptor antagonist-1 (compound 1) is a potent, reversible, and agonist dependent allosteric prostaglandin EP2 receptor antagonist.

EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research.

BAY-6672 is an effective and selective antagonist of the human prostaglandin F (FP) receptor, with an IC50 value of 11 nM.

BAY-6672 hydrochloride is an effective and selective antagonist of the human prostaglandin F (FP) receptor, with an IC50 value of 11 nM.

HHS-0701 is a sulfur-triazole exchange (SuTEx) ligand and an effective inhibitor of the tyrosine-reactive prostaglandin reductase 2 (PTGR2). HHS-0701 blocks the metabolism of lipid substrate 15-Keto-PGE2 by PTGR2.

ONO 1301 (ONO-AP 500-02) is a prostacyclin I2 analogue, an orally active long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. ONO 1301 promotes the production of hepatocyte growth factor (HGF) in different cell types and improves ischemia-induced left ventricular dysfunction in mice, rats, and pigs.

PDC31 (THG113.31; ILGHXDYK) is a allosteric and non-competitive inhibitor of the FP Prostaglandin Receptor. PDC31 is an oligopeptide based on D-amino acids, used as a smooth muscle contractant. In vivo, PDC31 reduces the intensity and duration of uterine contractions and can be used in research for preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca2+-dependent large conductance K+ channels in human uterine smooth muscle cells.

SC 51089 free base is a selective antagonist of the prostaglandin receptor EP1, with Ki values of 1.3, 11.2, 17.5 and 61.1 μM for EP1, TP, EP3 and FP receptors respectively. SC 51089 free base has neuroprotective activity.

PGN-9856 is a selective and high affinity (pKi ≥ 8.3) ligand at EP2 receptor.

EP4-IN-1 is a potent prostanoid EP4 receptor inhibitor.

Sulotroban (SKF-95587; BM-13177) is a selective antagonist for thromboxane A2 receptor (TXA2 Receptor).

MRE-269-d7 is deuterium labeled MRE-269 .

trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.

Ibuprofen guaiacol ester (AF 2259; Metoxibutropate) is a potent and orally active prostaglandin synthesis inhibitor.

Satigrel (E5510) is a potent inhibitor of platelet aggregation.

TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation.