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Home >> Signaling Pathways >> GPCR/G protein >> Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin receptors are a group of g-protein coupled receptor that exhibited a variety of functions in regulation of blood pressure and renal function; smooth muscle contraction; inhibition of plate aggregation; immune response etc.

Products for  Prostaglandin Receptor

  1. Cat.No. Product Name Information
  2. GC16838 (±)-Cloprostenol sodium salt

    (±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol

    prostaglandin F2α (PGF2α) analog,FP receptor agonist

     (±)-Cloprostenol sodium salt Chemical Structure
  3. GC30743 (+)-Cloprostenol (D-Cloprostenol)

    DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α

     (+)-Cloprostenol (D-Cloprostenol) is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor. (+)-Cloprostenol (D-Cloprostenol) Chemical Structure
  4. GC45259 (+)-Cloprostenol (sodium salt)

    DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α

     (+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol. (+)-Cloprostenol (sodium salt) Chemical Structure
  5. GC12750 (+)-Fluprostenol

    16mtrifluoromethylphenoxy tetranor Prostaglandin F2α

     Prostaglandin F2α (FP) receptor agonist (+)-Fluprostenol Chemical Structure
  6. GC11133 16,16-Dimethyl Prostaglandin E2

    16,16dimethyl PGE2

    derivative of prostaglandin E2

     16,16-Dimethyl Prostaglandin E2 Chemical Structure
  7. GC30561 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide Chemical Structure
  8. GC17719 5-trans U-46619

    5,6-trans U-46619

     Prostaglandin E synthase inhibitor 5-trans U-46619 Chemical Structure
  9. GC10623 ACS 67 analog of latanoprost (free acid),prostaglandin (PG) analog ACS 67 Chemical Structure
  10. GC30572 Aganepag (AGN 210937)

    AGN 210937

     Aganepag (AGN 210937) is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM, and shows no activity at EP4 receptor. Aganepag (AGN 210937) Chemical Structure
  11. GC64435 Aganepag isopropyl

    AGN-210961

     Aganepag isopropyl (AGN-210961) is an EP2 agonist. Aganepag isopropyl Chemical Structure
  12. GC31972 AGN 210676 (Simenepag)

    Simenepag

     AGN 210676 (Simenepag) is a selective prostaglandin EP2 agonist extracted from patent US20070203222A1, Compound example 23, has an EC50 of 5 nM. AGN 210676 (Simenepag) Chemical Structure
  13. GC40750 Agnuside Agnuside is an iridoid glycoside originally isolated from V. Agnuside Chemical Structure
  14. GC17224 AH 23848 (calcium salt) dual antagonist of TP1 and EP4 receptors AH 23848 (calcium salt) Chemical Structure
  15. GC14879 AH 6809 An EP and DP receptor antagonist AH 6809 Chemical Structure
  16. GC16895 AL 8810

    Antagonist of prostaglandin F2α (FP) receptor.

     AL 8810 Chemical Structure
  17. GC16566 AL 8810 isopropyl ester lipid soluble, esterified prodrug form of AL 8810, a FP receptor antagonist AL 8810 isopropyl ester Chemical Structure
  18. GC32558 Aligeron Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties. Aligeron Chemical Structure
  19. GC17347 Alprostadil

    Prostaglandin E1, PGE1;Prostaglandin E1

     Alprostadil (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Alprostadil Chemical Structure
  20. GC31718 AM211 (AM211 free acid)

    AM211 free acid

     AM211 (AM211 free acid) is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. AM211 (AM211 free acid) Chemical Structure
  21. GC50240 AMG 853

    AMG 853

     AMG 853 (AMG 853) is a phenylacetic acid derivative. AMG 853 Chemical Structure
  22. GC31830 AMG-009 AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively. AMG-009 Chemical Structure
  23. GC31702 Asapiprant (S-555739)

    S-555739

     Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM. Asapiprant (S-555739) Chemical Structure
  24. GC31456 AZ-1355

    AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.

     AZ-1355 Chemical Structure
  25. GC60611 AZ12672857 AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM). AZ12672857 Chemical Structure
  26. GC12434 AZD1981 CRTh2 antagonist,potent and selective AZD1981 Chemical Structure
  27. GC61581 BAY 73-1449 BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 Chemical Structure
  28. GC15640 BAY u3405

    Ramatroban

     BAY u3405 is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding. BAY u3405 Chemical Structure
  29. GC64958 BAY-1316957 BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC50 of 15.3 nM for human EP4-R. BAY-1316957 Chemical Structure
  30. GC68738 BAY-6672

    BAY-6672 is an effective and selective antagonist of the human prostaglandin F (FP) receptor, with an IC50 value of 11 nM.

     BAY-6672 Chemical Structure
  31. GC68739 BAY-6672 hydrochloride

    BAY-6672 hydrochloride is an effective and selective antagonist of the human prostaglandin F (FP) receptor, with an IC50 value of 11 nM.

     BAY-6672 hydrochloride Chemical Structure
  32. GC31872 Benorilate (Benoral) Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid. Benorilate (Benoral) Chemical Structure
  33. GC38891 Beraprost sodium Beraprost sodium, a prostacyclin analog, is a stable and orally active prodrug of PGI2. Beraprost sodium Chemical Structure
  34. GC42927 BGC 20-1531 (hydrochloride)

    PGN 1531

     BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively. BGC 20-1531 (hydrochloride) Chemical Structure
  35. GC62867 BGC-20-1531 free base

    PGN 1531 free base

     BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKB of 7.6. BGC-20-1531 free base Chemical Structure
  36. GC31757 BI-671800

    AP-761

     An antagonist of CRTH2/DP2 BI-671800 Chemical Structure
  37. GC12687 Bimatoprost

    Bimatoprost, 15(S)Bimatoprost, 17phenyl trinor PGF2α ethyl amide

     prostaglandin analog Bimatoprost Chemical Structure
  38. GC14758 BM 567 dual acting antithrombogenic agent, acting as an inhibitor of thromboxane A2 (TXA2) synthase and as an antagonist of the TP receptor BM 567 Chemical Structure
  39. GC11820 BMY 45778 partial agonist at IP1 prostacyclin receptors BMY 45778 Chemical Structure
  40. GC32002 Bunaprolast (U66858) Bunaprolast (U66858) (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) Chemical Structure
  41. GC16539 Butaprost

    15deoxy16Shydroxy17cyclobutyl PGE1 methyl ester, TR 4979

     A selective agonist for the EP2 receptors Butaprost Chemical Structure
  42. GC14212 BW 245C DP1 receptor agonist BW 245C Chemical Structure
  43. GC14859 BW 246C

    8-epi BW 245C

     DP receptor agonist BW 246C Chemical Structure
  44. GC17348 BW A868C prostaglandin D2 antagonist BW A868C Chemical Structure
  45. GC32487 Carbacyclin (Carbaprostacyclin)

    Carbacyclin, cPGI

     Carbacyclin (Carbaprostacyclin) is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. Carbacyclin (Carbaprostacyclin) Chemical Structure
  46. GC50450 Carboprost tromethamine Synthetic Prostaglandin F2α analog Carboprost tromethamine Chemical Structure
  47. GC18318 CAY10441

    RO1138452

     CAY10441 is a potent and selective IP (prostacyclin) receptor antagonist. CAY10441 Chemical Structure
  48. GC35620 CAY10471 Racemate CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate Chemical Structure
  49. GC18678 CAY10595 The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. CAY10595 Chemical Structure
  50. GC61805 Cefminox sodium Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity. Cefminox sodium Chemical Structure
  51. GC31981 CGS 15435 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. CGS 15435 Chemical Structure
  52. GC31994 CI-949 CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively. CI-949 Chemical Structure
  53. GC10771 CJ-023423

    RQ-00000007

     CJ-023423 (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). CJ-023423 Chemical Structure
  54. GC13284 CJ-42794

    RQ-00015986

     EP4 antagonist CJ-42794 Chemical Structure
  55. GC31903 CRTh2 antagonist 1 CRTh2 antagonist 1 is a CRTh2 antagonist with an IC50 of 89 nM. CRTh2 antagonist 1 Chemical Structure
  56. GC31998 CRTH2-IN-1 (Ramatroban analog)

    Ramatroban analog

     CRTH2-IN-1 (Ramatroban analog) (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC50 of 6 nM in a human DP2 binding assay. CRTH2-IN-1 (Ramatroban analog) Chemical Structure
  57. GC38763 Daltroban

    BM 13505, SKF 96148

     Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban Chemical Structure
  58. GC38764 Darbufelone Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone Chemical Structure
  59. GC30604 Darbufelone mesylate (CI-1004 mesylate) Darbufelone mesylate (CI-1004 mesylate) (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone mesylate (CI-1004 mesylate) Chemical Structure
  60. GC38902 Dazoxiben Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor. Dazoxiben Chemical Structure
  61. GC50393 DG 041 Potent and selective EP3 antagonist; antiplatelet and antithrombotic DG 041 Chemical Structure
  62. GC30370 Dinoprost (Prostaglandin F2a)

    Dinoprost, PGF2α

     Dinoprost (Prostaglandin F2a) (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost (Prostaglandin F2a) Chemical Structure
  63. GC10673 E7046

    E7046

     antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4 E7046 Chemical Structure
  64. GC31202 EP1-antanoist-1 EP1-antanoist-1 is a EP1 antagonist with a pKi of 7.54 and an pIC50 of 8.5. EP1-antanoist-1 Chemical Structure
  65. GC65317 EP2 receptor antagonist-1 EP2 receptor antagonist-1 (compound 1) is a potent, reversible, and agonist dependent allosteric prostaglandin EP2 receptor antagonist. EP2 receptor antagonist-1 Chemical Structure
  66. GC65987 EP3 antagonist 3 EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research. EP3 antagonist 3 Chemical Structure
  67. GC71282 EP4-IN-1 EP4-IN-1 is a potent prostanoid EP4 receptor inhibitor. EP4-IN-1 Chemical Structure
  68. GC60152 Epibetulinic acid Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Epibetulinic acid Chemical Structure
  69. GC12101 Epoprostenol

    Epoprostenol, PGI2, Prostacyclin

     Epoprostenol (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol Chemical Structure
  70. GC50722 ER 819762 ER 819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor. ER 819762 Chemical Structure
  71. GC32540 Etersalate (Eterylate) Etersalate (Eterylate) inhibits platelet function and decreases thromboxane A2 (TXA2) levels. Etersalate (Eterylate) Chemical Structure
  72. GC16170 Ethamsylate Haemostatic drug Ethamsylate Chemical Structure
  73. GC19147 Evatanepag Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM. Evatanepag Chemical Structure
  74. GC19153 Fevipiprant

    NVP-QAW039, QAW039

     Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood. Fevipiprant Chemical Structure
  75. GC38379 Furprofen Furprofen is an non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. Furprofen Chemical Structure
  76. GN10069 Ginsenoside Ro

    Chikusetsusaponin V

     Ginsenoside Ro Chemical Structure
  77. GC30307 GSK-269984A GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC50 of 7.9. GSK-269984A Chemical Structure
  78. GC30299 GSK726701A GSK726701A is a novel prostaglandin E2 receptor 4 (EP4) partial agonist with a pEC50 of 7.4. GSK726701A Chemical Structure
  79. GC14812 GW 627368 prostanoid EP4 receptor antagonist GW 627368 Chemical Structure
  80. GC69224 HHS-0701

    HHS-0701 is a sulfur-triazole exchange (SuTEx) ligand and an effective inhibitor of the tyrosine-reactive prostaglandin reductase 2 (PTGR2). HHS-0701 blocks the metabolism of lipid substrate 15-Keto-PGE2 by PTGR2.

     HHS-0701 Chemical Structure
  81. GC68349 Ifetroban sodium

    BMS-180291 sodium

     Ifetroban sodium Chemical Structure
  82. GC15911 Iloprost

    Ciloprost

     Prostacyclin (PGI2) analog；IP, EP1 and EP3 receptors agonist Iloprost Chemical Structure
  83. GC36379 KAG-308 KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 Chemical Structure
  84. GC32653 KF 13218 KF 13218 is a potent, selective and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM. KF 13218 Chemical Structure
  85. GC31983 KP496 KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor. KP496 Chemical Structure
  86. GC62667 KW-8232 KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2. KW-8232 Chemical Structure
  87. GC31633 KW-8232 free base KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2. KW-8232 free base Chemical Structure
  88. GC31768 L 888607 L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 Chemical Structure
  89. GC31975 L 888607 Racemate L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively. L 888607 Racemate Chemical Structure
  90. GC14173 L-161,982 EP4 receptor antagonist L-161,982 Chemical Structure
  91. GC13067 L-655,240 thromboxane A2/prostaglandin endoperoxide receptor antagonist L-655,240 Chemical Structure
  92. GC13609 L-670,596 thromboxane A2/prostaglandin endoperoxide receptor antagonist L-670,596 Chemical Structure
  93. GC10304 L-798,106

    CM 9, GW 671021

     prostanoid EP3 receptor antagonist L-798,106 Chemical Structure
  94. GC44021 L-826,266 L-826,266 is a potent and selective competitive antagonist of the prostaglandin E2 receptor subtype EP3 (Ki = 0.8 nM). L-826,266 Chemical Structure
  95. GC39632 Laflunimus Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus Chemical Structure
  96. GC11833 Laropiprant

    Cardaptive; MK 0524; MK-0524,Laropiprant

    A potent, selective DP1 receptor antagonist Laropiprant Chemical Structure
  97. GC14004 Latanoprost

    CAY530500, 17phenyl13,14dihydro trinor PGF2α isopropyl ester, 17phenyl13,14dihydro trinor Prostaglandin F2α isopropyl ester

    FP prostaglandin receptor agonist

     Latanoprost Chemical Structure
  98. GC41229 Latanoprost (free acid)

    LatFA, 17phenyl13,14dihydro trinor Prostaglandin F2α, PhXA85

     Latanoprost (free acid), an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost (free acid) Chemical Structure
  99. GC40854 Latanoprost Lactone Diol Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Latanoprost Lactone Diol Chemical Structure
  100. GC33550 LCB-2853 LCB-2853 is an antagonist of thromboxane A2 (TXA2) receptor, with antiplatelet and antithrombotic activities. LCB-2853 Chemical Structure
  101. GC60225 Licarin A Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Licarin A Chemical Structure

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