Prostaglandin Receptor
Prostaglandin receptors are a group of g-protein coupled receptor that exhibited a variety of functions in regulation of blood pressure and renal function; smooth muscle contraction; inhibition of plate aggregation; immune response etc.
Products for Prostaglandin Receptor
- Cat.No. Product Name Information
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GC16838
(±)-Cloprostenol sodium salt
prostaglandin F2α (PGF2α) analog,FP receptor agonist
- GC30743 (+)-Cloprostenol (D-Cloprostenol) (+)-Cloprostenol (D-Cloprostenol) is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
- GC45259 (+)-Cloprostenol (sodium salt) (+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol.
- GC12750 (+)-Fluprostenol Prostaglandin F2α (FP) receptor agonist
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GC11133
16,16-Dimethyl Prostaglandin E2
derivative of prostaglandin E2
- GC30561 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.
- GC17719 5-trans U-46619 Prostaglandin E synthase inhibitor
- GC10623 ACS 67 analog of latanoprost (free acid),prostaglandin (PG) analog
- GC30572 Aganepag (AGN 210937) Aganepag (AGN 210937) is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM, and shows no activity at EP4 receptor.
- GC64435 Aganepag isopropyl Aganepag isopropyl (AGN-210961) is an EP2 agonist.
- GC31972 AGN 210676 (Simenepag) AGN 210676 (Simenepag) is a selective prostaglandin EP2 agonist extracted from patent US20070203222A1, Compound example 23, has an EC50 of 5 nM.
- GC40750 Agnuside Agnuside is an iridoid glycoside originally isolated from V.
- GC17224 AH 23848 (calcium salt) dual antagonist of TP1 and EP4 receptors
- GC14879 AH 6809 An EP and DP receptor antagonist
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GC16895
AL 8810
Antagonist of prostaglandin F2α (FP) receptor.
- GC16566 AL 8810 isopropyl ester lipid soluble, esterified prodrug form of AL 8810, a FP receptor antagonist
- GC32558 Aligeron Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
- GC17347 Alprostadil Alprostadil (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively.
- GC31718 AM211 (AM211 free acid) AM211 (AM211 free acid) is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
- GC50240 AMG 853 AMG 853 (AMG 853) is a phenylacetic acid derivative.
- GC31830 AMG-009 AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.
- GC31702 Asapiprant (S-555739) Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM.
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GC31456
AZ-1355
AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.
- GC60611 AZ12672857 AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM).
- GC12434 AZD1981 CRTh2 antagonist,potent and selective
- GC61581 BAY 73-1449 BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG.
- GC15640 BAY u3405 BAY u3405 is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.
- GC64958 BAY-1316957 BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC50 of 15.3 nM for human EP4-R.
- GC31872 Benorilate (Benoral) Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid.
- GC38891 Beraprost sodium Beraprost sodium, a prostacyclin analog, is a stable and orally active prodrug of PGI2.
- GC42927 BGC 20-1531 (hydrochloride) BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively.
- GC62867 BGC-20-1531 free base BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKB of 7.6.
- GC31757 BI-671800 An antagonist of CRTH2/DP2
- GC12687 Bimatoprost prostaglandin analog
- GC14758 BM 567 dual acting antithrombogenic agent, acting as an inhibitor of thromboxane A2 (TXA2) synthase and as an antagonist of the TP receptor
- GC11820 BMY 45778 partial agonist at IP1 prostacyclin receptors
- GC32002 Bunaprolast (U66858) Bunaprolast (U66858) (U66858) is a potent inhibitor of LTB4 production in human whole blood.
- GC16539 Butaprost A selective agonist for the EP2 receptors
- GC14212 BW 245C DP1 receptor agonist
- GC14859 BW 246C DP receptor agonist
- GC17348 BW A868C prostaglandin D2 antagonist
- GC32487 Carbacyclin (Carbaprostacyclin) Carbacyclin (Carbaprostacyclin) is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.
- GC50450 Carboprost tromethamine Synthetic Prostaglandin F2α analog
- GC18318 CAY10441 CAY10441 is a potent and selective IP (prostacyclin) receptor antagonist.
- GC35620 CAY10471 Racemate CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM).
- GC18678 CAY10595 The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2.
- GC61805 Cefminox sodium Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity.
- GC31981 CGS 15435 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
- GC31994 CI-949 CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.
- GC10771 CJ-023423 CJ-023423 (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
- GC13284 CJ-42794 EP4 antagonist
- GC31903 CRTh2 antagonist 1 CRTh2 antagonist 1 is a CRTh2 antagonist with an IC50 of 89 nM.
- GC31998 CRTH2-IN-1 (Ramatroban analog) CRTH2-IN-1 (Ramatroban analog) (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC50 of 6 nM in a human DP2 binding assay.
- GC38763 Daltroban Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist.
- GC38764 Darbufelone Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production.
- GC30604 Darbufelone mesylate (CI-1004 mesylate) Darbufelone mesylate (CI-1004 mesylate) (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production.
- GC38902 Dazoxiben Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor.
- GC50393 DG 041 Potent and selective EP3 antagonist; antiplatelet and antithrombotic
- GC30370 Dinoprost (Prostaglandin F2a) Dinoprost (Prostaglandin F2a) (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.
- GC10673 E7046 antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4
- GC31202 EP1-antanoist-1 EP1-antanoist-1 is a EP1 antagonist with a pKi of 7.54 and an pIC50 of 8.5.
- GC65317 EP2 receptor antagonist-1 EP2 receptor antagonist-1 (compound 1) is a potent, reversible, and agonist dependent allosteric prostaglandin EP2 receptor antagonist.
- GC65987 EP3 antagonist 3 EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research.
- GC60152 Epibetulinic acid Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively.
- GC12101 Epoprostenol Epoprostenol (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH).
- GC50722 ER 819762 ER 819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor.
- GC32540 Etersalate (Eterylate) Etersalate (Eterylate) inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
- GC16170 Ethamsylate Haemostatic drug
- GC19147 Evatanepag Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.
- GC19153 Fevipiprant Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.
- GC38379 Furprofen Furprofen is an non-steroidal anti-inflammatory drug (NSAID) with analgesic properties.
- GN10069 Ginsenoside Ro
- GC30307 GSK-269984A GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC50 of 7.9.
- GC30299 GSK726701A GSK726701A is a novel prostaglandin E2 receptor 4 (EP4) partial agonist with a pEC50 of 7.4.
- GC14812 GW 627368 prostanoid EP4 receptor antagonist
- GC68349 Ifetroban sodium
- GC15911 Iloprost Prostacyclin (PGI2) analog;IP, EP1 and EP3 receptors agonist
- GC36379 KAG-308 KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production.
- GC32653 KF 13218 KF 13218 is a potent, selective and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.
- GC31983 KP496 KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.
- GC62667 KW-8232 KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
- GC31633 KW-8232 free base KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
- GC31768 L 888607 L 888607 is a potent, selective, stable and orally active CRTH2 agonist.
- GC31975 L 888607 Racemate L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.
- GC14173 L-161,982 EP4 receptor antagonist
- GC13067 L-655,240 thromboxane A2/prostaglandin endoperoxide receptor antagonist
- GC13609 L-670,596 thromboxane A2/prostaglandin endoperoxide receptor antagonist
- GC10304 L-798,106 prostanoid EP3 receptor antagonist
- GC44021 L-826,266 L-826,266 is a potent and selective competitive antagonist of the prostaglandin E2 receptor subtype EP3 (Ki = 0.8 nM).
- GC39632 Laflunimus Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726.
- GC11833 Laropiprant A potent, selective DP1 receptor antagonist
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GC14004
Latanoprost
FP prostaglandin receptor agonist
- GC41229 Latanoprost (free acid) Latanoprost (free acid), an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor.
- GC40854 Latanoprost Lactone Diol Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.
- GC33550 LCB-2853 LCB-2853 is an antagonist of thromboxane A2 (TXA2) receptor, with antiplatelet and antithrombotic activities.
- GC60225 Licarin A Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells.
- GC62493 MF-766 MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM.
- GC16800 MF498 EP4 receptor antagonist
- GC16074 Misoprostol synthetic prostaglandin E1 (PGE1) analog
- GC41442 Misoprostol (free acid) Misoprostol (free acid) is an active metabolite of Misoprostol.