Prostaglandin Receptor
Prostaglandin receptors are a group of g-protein coupled receptor that exhibited a variety of functions in regulation of blood pressure and renal function; smooth muscle contraction; inhibition of plate aggregation; immune response etc.
Products for Prostaglandin Receptor
- Cat.No. Product Name Information
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GC16838
(±)-Cloprostenol sodium salt
(±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol
prostaglandin F2α (PGF2α) analog,FP receptor agonist
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GC30743
(+)-Cloprostenol (D-Cloprostenol)
DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α
(+)-Cloprostenol (D-Cloprostenol) is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor. -
GC45259
(+)-Cloprostenol (sodium salt)
DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α
(+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol. -
GC12750
(+)-Fluprostenol
16mtrifluoromethylphenoxy tetranor Prostaglandin F2α
Prostaglandin F2α (FP) receptor agonist -
GC11133
16,16-Dimethyl Prostaglandin E2
16,16dimethyl PGE2
derivative of prostaglandin E2
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GC30561
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.
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GC17719
5-trans U-46619
5,6-trans U-46619
Prostaglandin E synthase inhibitor -
GC10623
ACS 67
analog of latanoprost (free acid),prostaglandin (PG) analog
-
GC30572
Aganepag (AGN 210937)
AGN 210937
Aganepag (AGN 210937) is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM, and shows no activity at EP4 receptor. -
GC64435
Aganepag isopropyl
AGN-210961
Aganepag isopropyl (AGN-210961) is an EP2 agonist. -
GC31972
AGN 210676 (Simenepag)
Simenepag
AGN 210676 (Simenepag) is a selective prostaglandin EP2 agonist extracted from patent US20070203222A1, Compound example 23, has an EC50 of 5 nM. -
GC40750
Agnuside
Agnuside is an iridoid glycoside originally isolated from V.
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GC17224
AH 23848 (calcium salt)
dual antagonist of TP1 and EP4 receptors
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GC14879
AH 6809
An EP and DP receptor antagonist
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GC16895
AL 8810
Antagonist of prostaglandin F2α (FP) receptor.
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GC16566
AL 8810 isopropyl ester
lipid soluble, esterified prodrug form of AL 8810, a FP receptor antagonist
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GC32558
Aligeron
Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
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GC17347
Alprostadil
Prostaglandin E1, PGE1;Prostaglandin E1
Alprostadil (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. -
GC31718
AM211 (AM211 free acid)
AM211 free acid
AM211 (AM211 free acid) is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. -
GC50240
AMG 853
AMG 853
AMG 853 (AMG 853) is a phenylacetic acid derivative. -
GC31830
AMG-009
AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.
-
GC31702
Asapiprant (S-555739)
S-555739
Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM. -
GC31456
AZ-1355
AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.
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GC60611
AZ12672857
AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM).
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GC12434
AZD1981
CRTh2 antagonist,potent and selective
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GC61581
BAY 73-1449
BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG.
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GC15640
BAY u3405
Ramatroban
BAY u3405 is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding. -
GC64958
BAY-1316957
BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC50 of 15.3 nM for human EP4-R.
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GC68738
BAY-6672
BAY-6672 is an effective and selective antagonist of the human prostaglandin F (FP) receptor, with an IC50 value of 11 nM.
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GC68739
BAY-6672 hydrochloride
BAY-6672 hydrochloride is an effective and selective antagonist of the human prostaglandin F (FP) receptor, with an IC50 value of 11 nM.
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GC31872
Benorilate (Benoral)
Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid.
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GC38891
Beraprost sodium
Beraprost sodium, a prostacyclin analog, is a stable and orally active prodrug of PGI2.
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GC42927
BGC 20-1531 (hydrochloride)
PGN 1531
BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively. -
GC62867
BGC-20-1531 free base
PGN 1531 free base
BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKB of 7.6. -
GC31757
BI-671800
AP-761
An antagonist of CRTH2/DP2 -
GC12687
Bimatoprost
Bimatoprost, 15(S)Bimatoprost, 17phenyl trinor PGF2α ethyl amide
prostaglandin analog -
GC14758
BM 567
dual acting antithrombogenic agent, acting as an inhibitor of thromboxane A2 (TXA2) synthase and as an antagonist of the TP receptor
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GC11820
BMY 45778
partial agonist at IP1 prostacyclin receptors
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GC32002
Bunaprolast (U66858)
Bunaprolast (U66858) (U66858) is a potent inhibitor of LTB4 production in human whole blood.
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GC16539
Butaprost
15deoxy16Shydroxy17cyclobutyl PGE1 methyl ester, TR 4979
A selective agonist for the EP2 receptors -
GC14212
BW 245C
DP1 receptor agonist
-
GC14859
BW 246C
8-epi BW 245C
DP receptor agonist -
GC17348
BW A868C
prostaglandin D2 antagonist
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GC32487
Carbacyclin (Carbaprostacyclin)
Carbacyclin, cPGI
Carbacyclin (Carbaprostacyclin) is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. -
GC50450
Carboprost tromethamine
Synthetic Prostaglandin F2α analog
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GC18318
CAY10441
RO1138452
CAY10441 is a potent and selective IP (prostacyclin) receptor antagonist. -
GC35620
CAY10471 Racemate
CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM).
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GC18678
CAY10595
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2.
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GC61805
Cefminox sodium
Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity.
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GC31981
CGS 15435
CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
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GC31994
CI-949
CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.
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GC10771
CJ-023423
RQ-00000007
CJ-023423 (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). -
GC13284
CJ-42794
RQ-00015986
EP4 antagonist -
GC31903
CRTh2 antagonist 1
CRTh2 antagonist 1 is a CRTh2 antagonist with an IC50 of 89 nM.
-
GC31998
CRTH2-IN-1 (Ramatroban analog)
Ramatroban analog
CRTH2-IN-1 (Ramatroban analog) (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC50 of 6 nM in a human DP2 binding assay. -
GC38763
Daltroban
BM 13505, SKF 96148
Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. -
GC38764
Darbufelone
Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production.
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GC30604
Darbufelone mesylate (CI-1004 mesylate)
Darbufelone mesylate (CI-1004 mesylate) (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production.
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GC38902
Dazoxiben
Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor.
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GC50393
DG 041
Potent and selective EP3 antagonist; antiplatelet and antithrombotic
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GC30370
Dinoprost (Prostaglandin F2a)
Dinoprost, PGF2α
Dinoprost (Prostaglandin F2a) (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. -
GC10673
E7046
E7046
antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4 -
GC31202
EP1-antanoist-1
EP1-antanoist-1 is a EP1 antagonist with a pKi of 7.54 and an pIC50 of 8.5.
-
GC65317
EP2 receptor antagonist-1
EP2 receptor antagonist-1 (compound 1) is a potent, reversible, and agonist dependent allosteric prostaglandin EP2 receptor antagonist.
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GC65987
EP3 antagonist 3
EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research.
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GC71282
EP4-IN-1
EP4-IN-1 is a potent prostanoid EP4 receptor inhibitor.
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GC60152
Epibetulinic acid
Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively.
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GC12101
Epoprostenol
Epoprostenol, PGI2, Prostacyclin
Epoprostenol (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). -
GC50722
ER 819762
ER 819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor.
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GC32540
Etersalate (Eterylate)
Etersalate (Eterylate) inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
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GC16170
Ethamsylate
Haemostatic drug
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GC19147
Evatanepag
Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.
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GC19153
Fevipiprant
NVP-QAW039, QAW039
Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood. -
GC38379
Furprofen
Furprofen is an non-steroidal anti-inflammatory drug (NSAID) with analgesic properties.
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GN10069
Ginsenoside Ro
Chikusetsusaponin V
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GC30307
GSK-269984A
GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC50 of 7.9.
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GC30299
GSK726701A
GSK726701A is a novel prostaglandin E2 receptor 4 (EP4) partial agonist with a pEC50 of 7.4.
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GC14812
GW 627368
prostanoid EP4 receptor antagonist
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GC69224
HHS-0701
HHS-0701 is a sulfur-triazole exchange (SuTEx) ligand and an effective inhibitor of the tyrosine-reactive prostaglandin reductase 2 (PTGR2). HHS-0701 blocks the metabolism of lipid substrate 15-Keto-PGE2 by PTGR2.
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GC68349
Ifetroban sodium
BMS-180291 sodium
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GC15911
Iloprost
Ciloprost
Prostacyclin (PGI2) analog;IP, EP1 and EP3 receptors agonist -
GC36379
KAG-308
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production.
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GC32653
KF 13218
KF 13218 is a potent, selective and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.
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GC31983
KP496
KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.
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GC62667
KW-8232
KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
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GC31633
KW-8232 free base
KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
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GC31768
L 888607
L 888607 is a potent, selective, stable and orally active CRTH2 agonist.
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GC31975
L 888607 Racemate
L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.
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GC14173
L-161,982
EP4 receptor antagonist
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GC13067
L-655,240
thromboxane A2/prostaglandin endoperoxide receptor antagonist
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GC13609
L-670,596
thromboxane A2/prostaglandin endoperoxide receptor antagonist
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GC10304
L-798,106
CM 9, GW 671021
prostanoid EP3 receptor antagonist -
GC44021
L-826,266
L-826,266 is a potent and selective competitive antagonist of the prostaglandin E2 receptor subtype EP3 (Ki = 0.8 nM).
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GC39632
Laflunimus
Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726.
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GC11833
Laropiprant
Cardaptive; MK 0524; MK-0524,Laropiprant
A potent, selective DP1 receptor antagonist -
GC14004
Latanoprost
CAY530500, 17phenyl13,14dihydro trinor PGF2α isopropyl ester, 17phenyl13,14dihydro trinor Prostaglandin F2α isopropyl ester
FP prostaglandin receptor agonist
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GC41229
Latanoprost (free acid)
LatFA, 17phenyl13,14dihydro trinor Prostaglandin F2α, PhXA85
Latanoprost (free acid), an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. -
GC40854
Latanoprost Lactone Diol
Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.
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GC33550
LCB-2853
LCB-2853 is an antagonist of thromboxane A2 (TXA2) receptor, with antiplatelet and antithrombotic activities.
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GC60225
Licarin A
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells.