Prostaglandin Receptor

Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α.

Agnuside is an iridoid glycoside originally isolated from V.

Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.

Latanoprost (free acid), an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor.

Misoprostol (free acid) is an active metabolite of Misoprostol.

BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively.

L-826,266 is a potent and selective competitive antagonist of the prostaglandin E2 receptor subtype EP3 (Ki = 0.8 nM).

Nedocromil (sodium salt) suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

(+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol.

Selective prostacyclin IP receptor antagonist

AMG 853 (AMG 853) is a phenylacetic acid derivative.

Potent and selective EP3 antagonist; antiplatelet and antithrombotic

Synthetic Prostaglandin F2α analog

ER 819762 is an orally active, highly selective prostaglandin E2 (PGE2) EP4 receptor antagonist with an EC50 of 70 nM against human EP4 receptor.

Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively.

Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells.

Internal standard for the quantification of misoprostol (free acid)

AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM).

An internal standard for the quantification of rebamipide

BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG.

Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity.

MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM.

KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.

BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKB of 7.6.