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Prostaglandin Receptor

Prostaglandin receptors are a group of g-protein coupled receptor that exhibited a variety of functions in regulation of blood pressure and renal function; smooth muscle contraction; inhibition of plate aggregation; immune response etc.

Products for  Prostaglandin Receptor

  1. Cat.No. Product Name Information
  2. GC60248 Misoprostol acid D5 Internal standard for the quantification of misoprostol (free acid) Misoprostol acid D5  Chemical Structure
  3. GC16477 MK-2894 MK-2894  Chemical Structure
  4. GC36623 MK-2894 sodium salt MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM). MK-2894 sodium salt  Chemical Structure
  5. GC31966 MK-447 MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins. MK-447  Chemical Structure
  6. GC19395 MK-7246 MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM. MK-7246  Chemical Structure
  7. GC36624 MK-7246 S enantiomer MK-7246 S enantiomer is the less active enantiomer of MK-7246. MK-7246 S enantiomer  Chemical Structure
  8. GC31851 MK-8318 MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM. MK-8318  Chemical Structure
  9. GC34015 MRE-269 (ACT-333679) MRE-269 (ACT-333679) is an active metabolite of selexipag, and acts as a selective IP receptor agonist. MRE-269 (ACT-333679)  Chemical Structure
  10. GC17000 Nedocromil anti-inflammatory agent Nedocromil  Chemical Structure
  11. GC44360 Nedocromil (sodium salt) Nedocromil (sodium salt) suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2). Nedocromil (sodium salt)  Chemical Structure
  12. GC12290 Norgestimate synthetic progesterone analog Norgestimate  Chemical Structure
  13. GC16639 NS 304 NS 304 (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor). NS 304  Chemical Structure
  14. GC38827 NTP42 NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46609. NTP42  Chemical Structure
  15. GC32413 OBE022 OBE022 (OBE022) is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively. OBE022  Chemical Structure
  16. GC69625 ONO 1301

    ONO 1301 (ONO-AP 500-02) is a prostacyclin I2 analogue, an orally active long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. ONO 1301 promotes the production of hepatocyte growth factor (HGF) in different cell types and improves ischemia-induced left ventricular dysfunction in mice, rats, and pigs.

    ONO 1301  Chemical Structure
  17. GC16027 ONO-8711 EP1 receptor antagonist ONO-8711  Chemical Structure
  18. GC67726 ONO-8711 dicyclohexylamine ONO-8711 dicyclohexylamine  Chemical Structure
  19. GC15662 ONO-AE3-208 An EP4 receptor antagonist ONO-AE3-208  Chemical Structure
  20. GC12403 Ozagrel HCl Ozagrel HCl (OKY-046 hydrochloride) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel HCl  Chemical Structure
  21. GC33471 p-Hydroxycinnamic acid (NSC 59260) p-Hydroxycinnamic acid (NSC 59260), a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. p-Hydroxycinnamic acid (NSC 59260)  Chemical Structure
  22. GC69678 PDC31

    PDC31 (THG113.31; ILGHXDYK) is a allosteric and non-competitive inhibitor of the FP Prostaglandin Receptor. PDC31 is an oligopeptide based on D-amino acids, used as a smooth muscle contractant. In vivo, PDC31 reduces the intensity and duration of uterine contractions and can be used in research for preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca2+-dependent large conductance K+ channels in human uterine smooth muscle cells.

    PDC31  Chemical Structure
  23. GC64921 Pexopiprant Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki < 100nM. Pexopiprant  Chemical Structure
  24. GC11067 PF 04418948

    EP2 receptor antagonist

    PF 04418948  Chemical Structure
  25. GC63148 Pizuglanstat Pizuglanstat (compound 3) is a prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthases (H-PGDS). Pizuglanstat  Chemical Structure
  26. GC15948 Prostaglandin E2

    Prostaglandin E2 is a major metabolite produced from arachidonic acid catalyzed by Cyclooxygenase (COX).

    Prostaglandin E2  Chemical Structure
  27. GC15622 Prostaglandin F2α Prostaglandin F2α (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Prostaglandin F2α  Chemical Structure
  28. GC40591 Prostaglandin F2β Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α. Prostaglandin F2β  Chemical Structure
  29. GC31820 Quinotolast sodium (FR71021) Quinotolast sodium (FR71021) in the concentration range of 1-100 μg/mL inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner. Quinotolast sodium (FR71021)  Chemical Structure
  30. GC32476 Ralinepag (APD811) Ralinepag (APD811) is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively. Ralinepag (APD811)  Chemical Structure
  31. GC17367 Rebamipide cholecystokinin type 1 (CCK1) receptor inhibitor Rebamipide  Chemical Structure
  32. GC61234 Rebamipide D4 An internal standard for the quantification of rebamipide Rebamipide D4  Chemical Structure
  33. GC64765 Ridogrel Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel  Chemical Structure
  34. GC50055 Ro 1138452 hydrochloride Selective prostacyclin IP receptor antagonist Ro 1138452 hydrochloride  Chemical Structure
  35. GC31837 RS-601 RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities. RS-601  Chemical Structure
  36. GC17410 S18886 S18886 is a thromboxane-prostaglandin receptor antagonist. S18886  Chemical Structure
  37. GC39053 Saikogenin D Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D  Chemical Structure
  38. GC14128 SC 19220 EP1 receptor antagonist SC 19220  Chemical Structure
  39. GC13165 SC 51089 EP1 prostanoid receptor antagonist SC 51089  Chemical Structure
  40. GC69865 SC 51089 free base

    SC 51089 free base is a selective antagonist of the prostaglandin receptor EP1, with Ki values of 1.3, 11.2, 17.5 and 61.1 μM for EP1, TP, EP3 and FP receptors respectively. SC 51089 free base has neuroprotective activity.

    SC 51089 free base  Chemical Structure
  41. GC15157 SC 51322 EP1 prostanoid receptor antagonist SC 51322  Chemical Structure
  42. GC18111 Seratrodast thromboxane A2 (TXA2) receptor (TP) antagonist Seratrodast  Chemical Structure
  43. GC19327 Setipiprant Setipiprant is an orally available, selective CRTH2 antagonist. Setipiprant  Chemical Structure
  44. GC15213 SQ 29,548 TP receptor antagonist SQ 29,548  Chemical Structure
  45. GC17861 Sulprostone

    EP3 and EP1 receptor agonist

    Sulprostone  Chemical Structure
  46. GC30068 Taprenepag (CP-544326) Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin EP(2) agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag (CP-544326)  Chemical Structure
  47. GC31919 Taprenepag isopropyl (PF-04217329) Taprenepag isopropyl (PF-04217329) is a highly selective EP2 receptor agonist. Taprenepag isopropyl (PF-04217329)  Chemical Structure
  48. GC11122 TCS 2510

    EP4 agonist

    TCS 2510  Chemical Structure
  49. GC32550 Terbogrel (BIBV 308SE) Terbogrel (BIBV 308SE) is an orally available thromboxane A2 receptor antagonist and a thromboxane A2 synthase inhibitor, with both IC50s of about 10 nM. Terbogrel (BIBV 308SE)  Chemical Structure
  50. GC13732 TG4-155 brain penetrant EP2 antagonist TG4-155  Chemical Structure
  51. GC19354 TG6-10-1 TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors. TG6-10-1  Chemical Structure
  52. GC31445 Tiaprost (Iliren) Tiaprost (Iliren) is a prostaglandin F2α (PGF2α) analogue. Tiaprost (Iliren)  Chemical Structure
  53. GC37794 Timapiprant A potent, selective DP2 antagonist Timapiprant  Chemical Structure
  54. GC37795 Timapiprant sodium Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant sodium  Chemical Structure
  55. GC37822 Travoprost A PGF analog and prodrug form of (+)-fluprostenol Travoprost  Chemical Structure
  56. GC31694 Treprostinil (LRX-15) Treprostinil (LRX-15) (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. Treprostinil (LRX-15)  Chemical Structure
  57. GC67982 Treprostinil palmitil Treprostinil palmitil  Chemical Structure
  58. GC31720 Treprostinil sodium (UT-15) Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. Treprostinil sodium (UT-15)  Chemical Structure
  59. GC13205 U 46619

    Selective agonist of PGH2/TxA2 (TP) receptor

    U 46619  Chemical Structure
  60. GC18132 U-44069 TP receptor agonist U-44069  Chemical Structure
  61. GC31980 YM158 free base (YM-57158) YM158 free base (YM-57158) is a potent and selective LTD4 and TXA2 receptor antagonist with pA2 values of about 8.87 and 8.81, respectively. YM158 free base (YM-57158)  Chemical Structure

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