Prostaglandin Receptor
Prostaglandin receptors are a group of g-protein coupled receptor that exhibited a variety of functions in regulation of blood pressure and renal function; smooth muscle contraction; inhibition of plate aggregation; immune response etc.
Products for Prostaglandin Receptor
- Cat.No. Product Name Information
- GC60248 Misoprostol acid D5 Internal standard for the quantification of misoprostol (free acid)
- GC16477 MK-2894
- GC36623 MK-2894 sodium salt MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM).
- GC31966 MK-447 MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins.
- GC19395 MK-7246 MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.
- GC36624 MK-7246 S enantiomer MK-7246 S enantiomer is the less active enantiomer of MK-7246.
- GC31851 MK-8318 MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.
- GC34015 MRE-269 (ACT-333679) MRE-269 (ACT-333679) is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
- GC17000 Nedocromil anti-inflammatory agent
- GC44360 Nedocromil (sodium salt) Nedocromil (sodium salt) suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
- GC12290 Norgestimate synthetic progesterone analog
- GC16639 NS 304 NS 304 (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
- GC38827 NTP42 NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46609.
- GC32413 OBE022 OBE022 (OBE022) is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.
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GC69625
ONO 1301
ONO 1301 (ONO-AP 500-02) is a prostacyclin I2 analogue, an orally active long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. ONO 1301 promotes the production of hepatocyte growth factor (HGF) in different cell types and improves ischemia-induced left ventricular dysfunction in mice, rats, and pigs.
- GC16027 ONO-8711 EP1 receptor antagonist
- GC67726 ONO-8711 dicyclohexylamine
- GC15662 ONO-AE3-208 An EP4 receptor antagonist
- GC12403 Ozagrel HCl Ozagrel HCl (OKY-046 hydrochloride) is a thromboxane A2 (TXA2) synthase inhibitor.
- GC33471 p-Hydroxycinnamic acid (NSC 59260) p-Hydroxycinnamic acid (NSC 59260), a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
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GC69678
PDC31
PDC31 (THG113.31; ILGHXDYK) is a allosteric and non-competitive inhibitor of the FP Prostaglandin Receptor. PDC31 is an oligopeptide based on D-amino acids, used as a smooth muscle contractant. In vivo, PDC31 reduces the intensity and duration of uterine contractions and can be used in research for preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca2+-dependent large conductance K+ channels in human uterine smooth muscle cells.
- GC64921 Pexopiprant Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki < 100nM.
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GC11067
PF 04418948
EP2 receptor antagonist
- GC63148 Pizuglanstat Pizuglanstat (compound 3) is a prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthases (H-PGDS).
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GC15948
Prostaglandin E2
Prostaglandin E2 is a major metabolite produced from arachidonic acid catalyzed by Cyclooxygenase (COX).
- GC15622 Prostaglandin F2α Prostaglandin F2α (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.
- GC40591 Prostaglandin F2β Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α.
- GC31820 Quinotolast sodium (FR71021) Quinotolast sodium (FR71021) in the concentration range of 1-100 μg/mL inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner.
- GC32476 Ralinepag (APD811) Ralinepag (APD811) is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
- GC17367 Rebamipide cholecystokinin type 1 (CCK1) receptor inhibitor
- GC61234 Rebamipide D4 An internal standard for the quantification of rebamipide
- GC64765 Ridogrel Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker.
- GC50055 Ro 1138452 hydrochloride Selective prostacyclin IP receptor antagonist
- GC31837 RS-601 RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.
- GC17410 S18886 S18886 is a thromboxane-prostaglandin receptor antagonist.
- GC39053 Saikogenin D Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects.
- GC14128 SC 19220 EP1 receptor antagonist
- GC13165 SC 51089 EP1 prostanoid receptor antagonist
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GC69865
SC 51089 free base
SC 51089 free base is a selective antagonist of the prostaglandin receptor EP1, with Ki values of 1.3, 11.2, 17.5 and 61.1 μM for EP1, TP, EP3 and FP receptors respectively. SC 51089 free base has neuroprotective activity.
- GC15157 SC 51322 EP1 prostanoid receptor antagonist
- GC18111 Seratrodast thromboxane A2 (TXA2) receptor (TP) antagonist
- GC19327 Setipiprant Setipiprant is an orally available, selective CRTH2 antagonist.
- GC15213 SQ 29,548 TP receptor antagonist
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GC17861
Sulprostone
EP3 and EP1 receptor agonist
- GC30068 Taprenepag (CP-544326) Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin EP(2) agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively.
- GC31919 Taprenepag isopropyl (PF-04217329) Taprenepag isopropyl (PF-04217329) is a highly selective EP2 receptor agonist.
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GC11122
TCS 2510
EP4 agonist
- GC32550 Terbogrel (BIBV 308SE) Terbogrel (BIBV 308SE) is an orally available thromboxane A2 receptor antagonist and a thromboxane A2 synthase inhibitor, with both IC50s of about 10 nM.
- GC13732 TG4-155 brain penetrant EP2 antagonist
- GC19354 TG6-10-1 TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.
- GC31445 Tiaprost (Iliren) Tiaprost (Iliren) is a prostaglandin F2α (PGF2α) analogue.
- GC37794 Timapiprant A potent, selective DP2 antagonist
- GC37795 Timapiprant sodium Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist.
- GC37822 Travoprost A PGF2α analog and prodrug form of (+)-fluprostenol
- GC31694 Treprostinil (LRX-15) Treprostinil (LRX-15) (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
- GC67982 Treprostinil palmitil
- GC31720 Treprostinil sodium (UT-15) Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
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GC13205
U 46619
Selective agonist of PGH2/TxA2 (TP) receptor
- GC18132 U-44069 TP receptor agonist
- GC31980 YM158 free base (YM-57158) YM158 free base (YM-57158) is a potent and selective LTD4 and TXA2 receptor antagonist with pA2 values of about 8.87 and 8.81, respectively.