NF-κB

TAK-243 (MLN7243) is a selective inhibitor of ubiquitin activating enzyme (UBA1) with an IC 50 value of 1nM.

DHMEQ racemate (rel-DHMEQ) is a NF-κB inhibitor. DHMEQ racemate (rel-DHMEQ) is less active than (-)-DHMEQ.

Cynaropicrin is a sesquiterpene lactone containing an α-methylene-γ-butyrolactone active group, isolated from the Ranunculaceae plant Saussurea lappa .

Rocaglamide (Rocaglamide A) is isolated from the genus Aglaia (family Meliaceae).

Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC 50 values of 10.08, 12.62, and 16.43μM, respectively.

Flaconitine (Acetylaconitine) is considered to be a NF-κB inhibitor.

Lidocaine hydrochloride (Lignocaine hydrochloride) is an amino-amide-type local anaesthetic that inhibits voltage-insensitive ‘flicker’ K + channel with an IC 50 value of 220μM.

Isovitexin (Saponaretin) extracted from rice hulls of Oryza sativa , possesses various biological activities, including anti-inflammatory and antioxidant activities.

Inulicin (1-O-Acetylbritannilactone) (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK.

Tectochrysin (Techtochrysin) (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin (Techtochrysin) inhibits activity of NF-κB.

Dendrophenol (Moscatilin) acts as a NF-κB inhibitor. Antineoplastic activity.

A water-soluble parthenolide analog

A phenol with diverse biological activities

7,4'-Dihydroxyflavone ,an orally active flavonoid isolated from Glycyrrhiza uralensis (licorice), functions as an inhibitor of eotaxin/CCL11 and carbonyl reductase 1 (CBR1) .

8-Deoxygartanin, a prenylated xanthones from G.

Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury.

Andrographolide (Andro) is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50.

Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice.

Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways.

Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd.

Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM.

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.

Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

Hyaluronidase degrades hyaluronic acid through the cleavage of glycosidic bonds. Initially discovered in bacteria, this enzyme is known to be widely distributed in nature and has been found in various species, including insects, snakes, fish, and mammals.