NF-κB

Hyaluronidase degrades hyaluronic acid through the cleavage of glycosidic bonds. Initially discovered in bacteria, this enzyme is known to be widely distributed in nature and has been found in various species, including insects, snakes, fish, and mammals.

IKKγ NBD Inhibitory Peptide is a NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region, which is shown to block TNF-alpha-induced NF-kB activation.

Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza inflate, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65.

Licoricidin is an isoflavonoid compound isolated from Glycyrrhiza uralensis Fisch , possessing various biological activities such as anticancer, antibacterial, and anti-inflammatory effects.

A flavonoid with antioxidant activity

Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways.

PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.

Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis.

Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity.

Dauricine is a bioactive alkaloid with anticancer properties extracted from Menispermum dauricum DC .

Dehydrodiisoeugenol (DEH) is a representative and major benzofuran-type neolignan found in Myristica fragrans Houtt, possessing antibacterial, anti-inflammatory, anticancer, and antioxidant properties.

Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes.

PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.

Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack.

Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica.

A chalcone metabolite with diverse biological activities

Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa.

A metabolite of ellagic acid

Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone.

TRAF-STOP inhibitor 6877002 is a selective inhibitor of CD40-TRAF6 interaction (TRAF-STOPs).

Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity.

Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways.