NF-κB

mucolytic

Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.

CORM-3 is a water soluble CO-releasing molecule, uncouples mitochondrial respiration via interaction with the phosphate carrier.

A racemate of Benpyrine, is a potent and orally active TNF-α inhibitor

Sivelestat sodium tetrahydrate is a specific inhibitor of neutrophil elastase with an IC 50 value of 14nM.

Denosumab is an IgG2 monoclonal antibody that targets the RANKL protein.

Rocaglamide is a potent NF-κB activation inhibitor.

Hyaluronidase from Bovine Testes is an endoglycosidase extracted from bovine testicles and belongs to the hyaluronidase family.

Hyaluronidase is an enzyme that hydrolyzes hyaluronic acid. Hyaluronidase can reduce tissue viscosity and increase tissue permeability through the hydrolysis of hyaluronic acid.

Ginsenoside CK, a secondary ginsenoside biotransformed from major ginsenosides, is more bioavailable and soluble than its parent ginsenosides and holds great significance.

Cyclo(his-pro) (Cyclo(histidyl-proline)) is an endogenous, blood–brain-barrier-permeable cyclic dipeptide derived from thyrotropin-releasing hormone (TRH) catabolism.

Edasalonexent (CAT-1004) (CAT-1004) is an orally bioavailable NF-κB inhibitor.

SN50, the NF-κB cell permeable inhibitory peptide.

Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.

A flavonoid glycoside with antioxidant and anti-inflammatory activities

Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ.

A ginsenoside with diverse biological activities

NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM.

WAY-204688 (SIM-688) is an estrogen receptor (ER-α) selective, orally active inhibitor of NF-κB transcriptional activity with an IC50 of 122±30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells.

An Analytical Reference Standard

Ginsenoside Rk3 is a rare saponin component extracted from ginseng or Panax notoginseng. Ginsenoside Rk3 possesses diverse biological activities, such as inhibiting TNF-α-induced NF-κB transcriptional activity (IC 50 =14.24±1.30μM).

A pyran with diverse biological activities

Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica.

(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue.