Tomatidine (hydrochloride) |
| Catalog No.GC45064 |
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6192-62-7
Sample solution is provided at 25 µL, 10mM.
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Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine in studies involving signaling mediated by the hedgehog pathway.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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