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Home >> Signaling Pathways >> Metabolism >> IDO

IDO

Indoleamine 2,3-dioxygenase (IDO) is an enzyme catalyzing the oxidative degradation of L-tryptophan in the kynurenine pathway, in which the pyrrole ring of L-tryptophan is cleaved to generate N-formyl-kynurenine. Mature human IDO enzyme is a 45 kDa monomeric protein of 403 amino acids that is encoded by the IDO gene (15 kb with 10 exons). According to X-ray crystallographic analysis, the chemical structure of human IDO enzyme consists of two distinct α-helical domains (one small and one large) and a heme prosthetic group, where the heme is coordinated to the active site by a histidine (His) imidazole as the proximal fifth ligand.

Products for  IDO

  1. Cat.No. Product Name Information
  2. GC70609 (R)-IDO/TDO-IN-1 (R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties. (R)-IDO/TDO-IN-1 Chemical Structure
  3. GC61750 (Rac)-Indoximod (Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. (Rac)-Indoximod Chemical Structure
  4. GC69891 (S)-Indoximod-d3

    1-Methyl-L-tryptophan-d3; (S)-NLG-8189-d3

    (S)-Indoximod-d3 is the deuterated form of (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for cancer research.

     (S)-Indoximod-d3 Chemical Structure
  5. GC19079 BMS-986205

    BMS-986205; ONO-7701

     BMS-986205 (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 value of 1.1 nM in IDO1-HEK293 cells. BMS-986205 is well tolerated with potent pharmacodynamic activity in advanced cancers. BMS-986205 Chemical Structure
  6. GC62496 BMS-986242 BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer. BMS-986242 Chemical Structure
  7. GN10414 Coptisine Coptisine Chemical Structure
  8. GN10577 Coptisine chloride Coptisine chloride Chemical Structure
  9. GN10609 Coptisine Sulfate Coptisine Sulfate Chemical Structure
  10. GC67714 DP00477 DP00477 Chemical Structure
  11. GC33671 GNF-PF-3777 (8-Nitrotryptanthrin)

    GNF-PF-3777

     GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM. GNF-PF-3777 (8-Nitrotryptanthrin) Chemical Structure
  12. GC34621 IACS-8968 IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. IACS-8968 Chemical Structure
  13. GC34622 IACS-8968 R-enantiomer IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. IACS-8968 R-enantiomer Chemical Structure
  14. GC34623 IACS-8968 S-enantiomer IACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. IACS-8968 S-enantiomer Chemical Structure
  15. GC14425 IDO inhibitor 1 Indoleamine-2,3-dioxygenase inhibitor IDO inhibitor 1 Chemical Structure
  16. GC15876 IDO-IN-1 indoleamine-2,3-dioxygenase (IDO) inhibitor IDO-IN-1 Chemical Structure
  17. GC36295 IDO-IN-11 IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 13. IDO-IN-11 Chemical Structure
  18. GC33963 IDO-IN-12 IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1. IDO-IN-12 Chemical Structure
  19. GC33012 IDO-IN-2

    PCC0208009

     IDO-IN-2 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. IDO-IN-2 Chemical Structure
  20. GC33058 IDO-IN-3 An inhibitor of IDO1 IDO-IN-3 Chemical Structure
  21. GC32899 IDO-IN-4

    IDO-IN-4

     IDO-IN-4 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1. IDO-IN-4 Chemical Structure
  22. GC34137 IDO-IN-5 (NLG-1489)

    NLG-1489

     IDO-IN-5 (NLG-1489) (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC50 of 1-10 μM. IDO-IN-5 (NLG-1489) Chemical Structure
  23. GC34149 IDO-IN-6 (NLG-1486)

    NLG-1486

     IDO-IN-6 (NLG-1486) (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM. IDO-IN-6 (NLG-1486) Chemical Structure
  24. GC34139 IDO-IN-8 (NLG-1487)

    NLG-1487

     IDO-IN-8 (NLG-1487) (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM. IDO-IN-8 (NLG-1487) Chemical Structure
  25. GC33191 IDO-IN-9 IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6. IDO-IN-9 Chemical Structure
  26. GC36294 IDO/TDO-IN-1 IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively . IDO/TDO-IN-1 Chemical Structure
  27. GC69255 IDO1-IN-18

    IDO1-IN-18 (Compound 14) is an effective IDO1 inhibitor. It has the potential to be used in cancer research.

     IDO1-IN-18 Chemical Structure
  28. GC65895 IDO1-IN-19 IDO1-IN-19 (Compound 17) is a potent inhibitor of IDO1. IDO1-IN-19 has the potential for the research of cancer diseases. IDO1-IN-19 Chemical Structure
  29. GC65499 IDO1/2-IN-1 hydrochloride IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active. IDO1/2-IN-1 hydrochloride Chemical Structure
  30. GC69256 IDO1/TDO-IN-4

    IDO1/TDO-IN-4 is an effective IDO1/TDO dual inhibitor with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 can form hydrogen bonds with IDO1 and undergoes π-π stacking interactions with TDO. It can be used for research on depression, infectious diseases caused by depression, metabolic diseases, and autoimmune diseases.

     IDO1/TDO-IN-4 Chemical Structure
  31. GC69257 IDO2-IN-1

    IDO2-IN-1 is a potent orally active inhibitor of indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 112 nM. It can be used for research on inflammatory autoimmune diseases.

     IDO2-IN-1 Chemical Structure
  32. GC17968 INCB-024360

    INCB024360

     INCB-024360 (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM. INCB-024360 Chemical Structure
  33. GC15846 INCB024360 analogue

    IDO5L

     A selective IDO1 inhibitor INCB024360 analogue Chemical Structure
  34. GC11066 Indoximod (NLG-8189)

    D-1MT, Indoximod

     Indoximod (NLG-8189) (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod (NLG-8189) acts as a Trp mimetic in regulating mTOR. Indoximod (NLG-8189) is an immunometabolic adjuvant used for the research of cancer. Indoximod (NLG-8189) Chemical Structure
  35. GC64060 Kushenol E Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7??M and a Ki of 9.5??M, has anti-tumor activity. Kushenol E Chemical Structure
  36. GC33287 LY-3381916

    IDO1-IN-5

     LY-3381916 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. LY-3381916 Chemical Structure
  37. GC13519 Navoximod

    GDC-0919; NLG-?919

     Navoximod (GDC-0919; NLG-?919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. Navoximod Chemical Structure
  38. GC11008 Necrostatin-1

    MTH-DL-Tryptophan,Nec-1

     Necrostatin-1 mainly acts on RIP1 in cells [5], Necrostatin-1 is a RIP1 kinase inhibitor with an IC50 value of 0.32 mM. Necrostatin-1 Chemical Structure
  39. GC64955 NLG802 NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor. NLG802 Chemical Structure
  40. GC13912 NLG919

    GDC-0919

     An IDO pathway inhibitor NLG919 Chemical Structure
  41. GC15833 Norharmane

    2-Azacarbazole,β-Carboline,2,9-Diazafluorene,NSC 84417

     inhibitor of indoleamine 2,3-dioxygenase Norharmane Chemical Structure
  42. GC39127 Palmatine Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine Chemical Structure
  43. GC68133 Palmatine hydroxide Palmatine hydroxide Chemical Structure
  44. GC32879 PF-06840003 (EOS200271)

    PF-06840003

     PF-06840003 (EOS200271) (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively. PF-06840003 (EOS200271) Chemical Structure
  45. GC62689 PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 Chemical Structure
  46. GC70167 ZC0109

    ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1), with IC50 values of 50 nM and 3.0 μM, respectively. ZC0109 induces the accumulation of reactive oxygen species (ROS), causing cell cycle arrest at the G1/S phase and leading to apoptosis in cancer cells.

     ZC0109 Chemical Structure

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