GLPBio

Glucosidase

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Glucosidases are glycoside hydrolase enzymes.

α-glucosidase is a glucosidase located in the brush border of the small intestine that acts upon α(1→4) bonds. α-Glucosidase inhibitor is a new type of antidiabetics. By reducing the postprandial blood sugar concentration, it can effectively control the blood sugar levels, thereby reducing the occurrence of diabetic complications.

β-glucosidase catalyzes the hydrolysis of the glycosidic bonds to terminal non-reducing residues in β-D-glucosides and oligosaccharides, with release of glucose. β-Glucosidase has attracted substantial attention in the scientific community because of its pivotal role in cellulose degradation, glycoside transformation and many other industrial processes. β-glucosidases catalyze the final step of cellulose hydrolysis and are essential in cellulose degradation.

Products Related to Glucosidase(47)

  • GC62984 structure
    GC62984Ganoderic acid Y
    CAS: 86377-52-8
    Purity: >98.00%

    Ganoderic acid Y is HMG-CoA Reductase inhibitor and α-glucosidase inhibitor with IC 50 s of 8.6μM and 170μM, respectively.

  • GC63099 structure
    GC63099NCGC00092410
    CAS: 442898-34-2
    Purity: >99.50%

    NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM.

  • GC63442 structure
    GC63442N-Caffeoyl O-methyltyramine
    CAS: 189307-47-9
    Purity: >98%

    N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM).

  • GC64202 structure
    GC64202Ganoderlactone D
    CAS: 1801934-15-5
    Purity: >99.00%

    Ganoderlactone D shows inhibitory effects of yeast α-Glucosidase with IC50 values of 41.7 μM.

  • GC64507 structure
    GC64507ML198
    CAS: 1380716-06-2
    Purity: >98.00%

    ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM.

  • GC64519 structure
    GC64519Kaempferol-3,7-di-O-β-glucoside
    CAS: 25615-14-9
    Purity: >98%

    Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and Acetylcholinesterase.

  • GC65271 structure
    GC65271p-Hydroxyphenethyl trans-ferulate
    CAS: 84873-15-4
    Purity: >99.00%

    p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic（yeast α-glucosidase，IC50 19.24 ± 1.73 ?mol L-1）, antioxidant, and anti-inflammatory activities.

  • GC67983 structure
    GC67983Norathyriol
    CAS: 3542-72-1
    Purity: >99.00%
  • GC68525 structure
    GC68525(2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid
    CAS: 132282-70-3
    Purity: >98%

    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin that can be isolated from Rubus ellipticus var. obcordatus. It inhibits α-Glucosidase with an IC50 of 1.68 mM.

  • GC69155 structure
    GC69155Gcase activator 2
    CAS: 2759897-35-1
    Purity: >99.00%

    Gcase activator 2 (compound 14) is a pyrrolo[2,3-b]pyridine and a beta-glucocerebrosidase (Gcase) activator with an EC50 of 3.8 μM. Gcase activator 2 induces Gcase dimerization (including k-type and v-type). Gcase activator 2 has low metabolic clearance in humans and mice.

  • GC70181 structure
    GC70181α-Glucosidase-IN-22
    CAS: 2870693-28-8
    Purity: >99.00%

    Alpha-glucosidase-IN-22 (compound 7i) is a benzimidazole, an effective inhibitor of alpha-glucosidase with an IC50 of 0.64 μM. Alpha-glucosidase-IN-22 is an effective anti-diabetic active molecule with potential for use in type 2 diabetes (T2DM) research.

  • GC70830 structure
    GC70830IHVR-17028
    CAS: 1428247-78-2

    IHVR-17028 is a potent and broad-spectrum antiviral agent.

  • GC71410 structure
    GC71410Cyclophellitol aziridine
    CAS: 136861-97-7
    Purity: >95.00%

    Cyclophellitol aziridine is a cyclophenol analogue and a potent β-glucosidase inhibitor.

  • GC71869 structure
    GC71869Caffeoyltryptophan
    CAS: 109163-69-1
    Purity: >96.00%

    Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM.

  • GC71877 structure
    GC71877Diphlorethohydroxycarmalol
    CAS: 138529-04-1
    Purity: >98.00%

    Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively.

  • GC71909 structure
    GC719092,7"-Phloroglucinol-6,6'-bieckol
    CAS: 1621988-60-0

    2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual α-amylase/α-glucosidase inhibitor with IC50 values of 6.94 μM and 23.35 μM respectively.

  • GC72043 structure
    GC72043Casuarictin
    CAS: 79786-00-8
    Purity: >98.00%

    Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL.

  • GC72494 structure
    GC724942-Hydroxyquinoline
    CAS: 59-31-4

    2-Hydroxyquinoline is a potent α-glucosidase inhibitor with IC50 values of 64.4, 130.5 µg/mL for α-glucosidase and α-amylase, respectively.

  • GC72710 structure
    GC72710α-Glucosidase-IN-35
    CAS: 24672-84-2

    α-Glucosidase-IN-35 (compound 1) is a kind of chromene.

  • GN10011 structure
    GN10011Rebaudioside A
    CAS: 58543-16-1
    Purity: >98.00%

    Rebaudioside A, from leaves of Stevia rebaudiana , inhibits α-glucosidase activity with IC 50 =35.01μg/ml.

  • GN10114 structure
    GN10114Oroxin A
    CAS: 57396-78-8
    Purity: >98.00%
  • GN10317 structure
    GN103171-Deoxynojirimycin
    CAS: 19130-96-2
    Purity: >98.00%

    1-Deoxynojirimycin is an alkaloid compound found in mulberry leaves and other plants. By inhibiting α-glucosidase and modulating various signaling pathways.

  • GN10551 structure
    GN10551Licochalcone C
    CAS: 144506-14-9
    Purity: >98.00%