ROR/RAR/RXR

LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.

PROTAC RAR Degrader-1 comprises a IAP ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).

WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19?μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity.

(+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.

AGN 195183 is an orally active, selective agonist for the retinoic acid receptor α (RARα).

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).

AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.

AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively.

all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid by GC- or LC-MS.

9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE.

9(S)-HETE is an enantiomer which makes up 50% of (±)9-HETE.

all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system.

LG 100268 is a highly potent and selective retinoid X receptor (RXR) agonist which strongly activates RXR homodimers with EC 50 value of 4nM.

Tazarotenic acid is an active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM.

An internal standard for the quantification of sodium butyrate

An oxysterol and agonist of RORγ and RORγt

A neuropeptide with diverse biological activities

An internal standard for the quantification of adapalene

A prodrug form of all-trans retinoic acid and butyric acid

A neuropeptide with diverse biological activities

A diterpenoid resin acid

A metabolite of all- trans retinoic acid