GLPBio

ROR/RAR/RXR

RAR/RXR is a heterodimer of RAR (retinoic acid receptor) and RXR (retinoid X receptor) that cause dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

Products Related to ROR/RAR/RXR(92)

  • GC49654 structure
    GC49654BMS 270394
    CAS: 262433-54-5
    Purity: >98.00%

    A RARγ agonist

  • GC50190 structure
    GC50190Fenretinide - d4
    CAS: 2118244-64-5
    Purity: >98%

    Fenretinide - d4 is the deuterium labeled Fenretinide.

  • GC52242 structure
    GC52242V-125
    CAS: 1807740-94-8
    Purity: >98.00%

    An RXR agonist

  • GC52325 structure
    GC52325MeTC7
    CAS: 1817841-22-7
    Purity: >98.00%

    MeTC7 is a vitamin D receptor (VDR) antagonist (IC 50 =2.9μM).

  • GC60076 structure
    GC60076Bigelovin
    CAS: 3668-14-2
    Purity: >99.50%

    Bigelovin, a sesquiterpene lactone isolated from Inula helianthus-aquatica, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.

  • GC63932 structure
    GC63932Amsilarotene
    CAS: 125973-56-0
    Purity: >99.00%

    Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer.

  • GC66433 structure
    GC66433Ro 41-5253
    CAS: 144092-31-9
    Purity: >98%

    Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity.

  • GC68629 structure
    GC68629AGN 192870
    CAS: 166977-57-7
    Purity: >98%

    AGN 192870 is a RAR neutral antagonist with Kd values of 147, 33, and 42 nM for RARα, RARβ, and RARγ respectively. The IC50 values for AGN 192870 are 87 and 32 nM for RARα and RARγ respectively. AGN 192870 exhibits partial agonistic activity on RARβ.

  • GC68781 structure
    GC68781BMS641
    CAS: 369364-50-1
    Purity: >98%

    BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has 100 times higher affinity for RARβ (Kd, 2.5 nM) than for RARα (Kd, 225 nM) or RARγ (Kd, 223 nM).

  • GC70155 structure
    GC70155YCT529
    CAS: 2863670-67-9
    Purity: >98.00%

    YCT529 is an effective, selective, and orally active RAR-α inhibitor.

  • GC70895 structure
    GC70895RXR antagonist 1
    CAS: 3010910-40-1
    Purity: >99.00%

    RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator.

  • GC72808 structure
    GC72808ER 50891 quarterhydrate
    Purity: >99.00%

    ER 50891 quarterdrate is a potent antagonist of retinoic acid receptor α(RARα).

  • GC73215 structure
    GC73215XS-060
    CAS: 346721-50-4
    Purity: >98.00%

    XS-060 is a potent anticancer agent and RXRα antagonist.

  • GC73494 structure
    GC73494MSU-42011
    CAS: 2456434-36-7
    Purity: >98.00%

    MSU-42011 is an orally active retinoid X receptor (RXR) agonist.

  • GC79766 structure
    GC79766Seletinoid G
    CAS: 637357-50-7
    Purity: >90.50%

    Seletinoid G is a retinoic acid receptor ( RAR ) agonist.

  • GC79767 structure
    GC79767NRX-204647
    CAS: 1351452-80-6
    Purity: >98%

    NRX-204647 is a potent activator of retinoic acid nuclear (RAR) with higher specificity than that to RAR and RAR.

  • GC79768 structure
    GC79768RARγ antagonist 1
    CAS: 859498-19-4
    Purity: >98%

    RARγ antagonist 1 (Compound in claim 4, P20) is a RARγ antagonist.

  • GC81691 structure
    GC81691Nurr1/RXR agonist 1
    CAS: 2231746-53-3
    Purity: >98.00%

    Nurr1/RXR dual agonist 1 is a dual activator of Nurr1 ( EC 50 = 2.6 µM) and RXR with K [1] s of 0.6 and 1.1 µM, respectively.

  • GN10301 structure
    GN10301Magnolol
    CAS: 528-43-8
    Purity: >99.50%

    Magnolol is a lignan compound extracted from the bark of Magnolia officinalis with multiple pharmacological activities. Magnolol is a dual agonist of RXRα (EC 50 =10.4µM) and PPARγ (EC 50 =17.7µM).

  • GC13664 structure
    GC13664AM580
    CAS: 102121-60-8
    Purity: >99.50%

    Selective RARα agonist