GLPBio

ROR/RAR/RXR

RAR/RXR is a heterodimer of RAR (retinoic acid receptor) and RXR (retinoid X receptor) that cause dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

Products Related to ROR/RAR/RXR(92)

  • GC14304 structure
    GC14304Palovarotene
    CAS: 410528-02-8
    Purity: >99.00%

    Selective retinoic acid receptor gamma(RAR-γ) agonist

  • GC14379 structure
    GC14379Adapalene sodium salt
    CAS: 911110-93-5
    Purity: >98%

    Retinoic acid receptor agonist

  • GC14511 structure
    GC14511All-trans Retinal
    CAS: 116-31-4
    Purity: >98.00%

    All-trans Retinal is a reactive vitamin A aldehyde with K d values of 50 and 90nM for CRBP-I and CRBP-II proteins, respectively.

  • GC14596 structure
    GC145969-cis-Retinoic Acid
    CAS: 5300-03-8
    Purity: ≥90.00%

    9-cis-Retinoic Acid is a high-affinity ligand for the retinoic acid receptor (RAR), with an EC 50 value of 0.2μM for RARα.

  • GC15382 structure
    GC15382Isotretinoin
    CAS: 4759-48-2
    Purity: >99.50%

    A retinoid

  • GC15459 structure
    GC15459Tazarotene
    CAS: 118292-40-3
    Purity: 99.95%

    Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor

  • GC15483 structure
    GC15483Luffariellolide
    CAS: 33564-30-6
    Purity: >98.00%

    agonist for the RA receptors RAR α, β, and γ

  • GC15648 structure
    GC15648BMS 493
    CAS: 215030-90-3
    Purity: >99.00%

    BMS 493 is a highly potent pan-retinoic acid receptor (pan-RARs) inverse agonist.

  • GC17063 structure
    GC17063Talarozole
    CAS: 201410-53-9
    Purity: >97.50%
  • GC17113 structure
    GC17113Acitretin sodium
    CAS: 925701-88-8
    Purity: >98%

    Second-generation, systemic retinoid

  • GC17143 structure
    GC17143Fenretinide
    CAS: 65646-68-6
    Purity: >99.00%

    A synthetic retinoic acid derivative

  • GC17382 structure
    GC17382BMS 961
    CAS: 185629-22-5
    Purity: >98.00%

    Selective RARγ agonist

  • GC17433 structure
    GC17433Phytol
    CAS: 150-86-7
    Purity: >98.00%

    activator of retinoid X receptors (RXRs)

  • GC17730 structure
    GC17730CD 3254
    CAS: 196961-43-0
    Purity: >98.00%

    RXRα agonist,potent and selective

  • GC18147 structure
    GC18147Tretinoin (Aberela)
    CAS: 302-79-4
    Purity: >98.00%

    Tretinoin (Aberela)is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as a ligand for nuclear RA receptors (RARs), with a K d value of 17nM for PPARβ/δ.

  • GC18482 structure
    GC18482all-trans-5,6-epoxy Retinoic Acid
    CAS: 13100-69-1
    Purity: >98%

    all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).

  • GC18632 structure
    GC186326-hydroxy Bexarotene
    CAS: 368451-07-4
    Purity: >98%

    6-hydroxy Bexarotene is an oxidative metabolite of bexarotene , a high-affinity ligand for retinoid X receptors (RXRs).

  • GC19035 structure
    GC19035AR7
    CAS: 80306-38-3
    Purity: >99.50%

    AR7 is an atypical retinoic acid receptor α (RARα) antagonist.

  • GC19232 structure
    GC19232LY2955303
    CAS: 1433497-19-8
    Purity: >99.00%

    LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.

  • GC31345 structure
    GC31345Retinol (Vitamin A1)
    CAS: 68-26-8
    Purity: >98.00%

    Retinol, also known as vitamin A1, is a fat-soluble vitamin in the vitamin A family that is found in food and used as a dietary supplement[1].

  • GC31935 structure
    GC31935Trifarotene (CD5789)
    CAS: 895542-09-3
    Purity: >99.50%

    Trifarotene (CD5789) (CD5789) is a potent and selective RARγ agonist.

  • GC32107 structure
    GC32107Peretinoin (NIK333)
    CAS: 81485-25-8
    Purity: >99.00%

    Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR).

  • GC32817 structure
    GC32817AGN 193109
    CAS: 171746-21-7
    Purity: >98.00%

    AGN 193109 is a novel, orally active, high-affinity pan-retinoic acid receptor (RAR) antagonist. AGN 193109 inhibits RARα (K D =2nM), RARβ (K D =2nM), and RARγ (K D =3nM) activities.

  • GC33315 structure
    GC33315AGN 194078
    CAS: 321995-62-4
    Purity: >98%

    AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.