Ligand for Target Protein for PROTAC
The PROTAC molecule consists of a ligand, which binds the target protein, connected by a linker to another ligand that binds the E3 ubiquitin ligase.
The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.
Products Related to Ligand for Target Protein for PROTAC(49)
- GC63443Piperidine-GNE-049-N-BocCAS: 1936431-36-5Purity: >98.50%
Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.
- GC63536BMS-1166-N-piperidine-COOHCAS: 2447066-00-2Purity: >98%
BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
- GC63717PROTAC Bcl-xL ligand-1Purity: >98%
PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs.
- GC73032PROTAC BRD4 ligand-2 hydrochloridePurity: >99.00%
PROTAC BRD4 ligand-2 drochloride is a ligand for target BRD4 protein for PROTAC CFT-2718.
- GC73510(S)-SKBG-1CAS: 2955618-24-1Purity: >99.00%
(S)-SKBG-1 is an inactive and covalent NONO ligand, used for assay control.
- GC74133SMARCA-BD ligand 1 for PROTAC hydrochlorideCAS: 2380272-56-8Purity: >99.00%
SMARCA-BD ligand 1 drochloride for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
- GC74139AZD9496 deacrylic acid phenolCAS: 2173404-70-9Purity: >96.00%
AZD9496 deacrylic acid phenol is a fragment of target protein ligand of PROTAC ER Degrader-4.
- GC80878RIPK2 ligand 3CAS: 2027561-86-8Purity: >99.00%
RIPK2 ligand 3 is a RIPK2 ligand and can be used for the synthesis of PROTACs, such as PROTAC RIPK degrader-2 [1] .
- GC80925KAT2A/B ligand 1CAS: 2254066-18-5Purity: >99.00%
KAT2A/B ligand 1 (compound 32a) is a KAT2A/B ligand.
- GC80926BI-7273 acidCAS: 2097514-90-2Purity: >98.00%
BI-7273 acid, BI-7273 derivative, is a BRD9 PROTAC ligand.
- GC80927NSD2 ligand 2CAS: 3031353-62-2Purity: >98.50%
NSD2 ligand 2 is a ligand for target protein for PROTAC that specifically binds to NSD2.
- GC80942IRF4 ligand-1CAS: 3113827-15-6Purity: >99.00%
IRF4 ligand-1 is an IRF4 ligand that can be used for the synthesis of PROTACs, such as dIRF4-2 [1] .
- GC80947JAK1/2 ligand 1CAS: 1026028-96-5Purity: >99.50%
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.
- GC81020JNK1 ligand-1-NH-Ph-COOHCAS: 3047792-63-9Purity: >98.00%
JNK1 ligand-1 (Compound P1) is a selective JNK1 inhibitor.
- GC81021p38α ligand-1CAS: 586379-64-8Purity: >98.50%
P38α ligand-1 is a p38α ligand that can be used for the synthesis of PROTACs, such as NR-7h [1] .
- GC81042PI3K/mTOR ligand-1CAS: 1197160-66-9Purity: >97.00%
PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC ( PI3K / mTOR ).
- GC81299c-Met ligand-1CAS: 1103506-79-1Purity: >98%
c-Met ligand-1 is a c-Met ligand and component of c-Met PROTAC degrader [1] .
- GC81513SMARCA2/4-ligand-8CAS: 2380272-41-1Purity: >99.50%
SMARCA2/4-ligand-8 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4-degrader-26 [1] .
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC63443 | Piperidine-GNE-049-N-Boc | 1936431-36-5 | >98.50% | |
Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP. | ||||
| GC63536 | BMS-1166-N-piperidine-COOH | 2447066-00-2 | >98% | |
BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. | ||||
| GC63717 | PROTAC Bcl-xL ligand-1 | - | >98% | |
PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs. | ||||
| GC67770 | Tazemetostat de(methyl morpholine)-COOH | 2685873-44-1 | >98.00% | |
| GC68434 | Dimethyl-F-OICR-9429-COOH | 2407458-49-3 | >98.00% | |
| GC73032 | PROTAC BRD4 ligand-2 hydrochloride | - | >99.00% | |
PROTAC BRD4 ligand-2 drochloride is a ligand for target BRD4 protein for PROTAC CFT-2718. | ||||
| GC73331 | BMS-37 | 1675202-20-6 | >98.00% | |
BMS-37 is a PD-1/PD-L1 immune checkpoint inhibitor. | ||||
| GC73510 | (S)-SKBG-1 | 2955618-24-1 | >99.00% | |
(S)-SKBG-1 is an inactive and covalent NONO ligand, used for assay control. | ||||
| GC74133 | SMARCA-BD ligand 1 for PROTAC hydrochloride | 2380272-56-8 | >99.00% | |
SMARCA-BD ligand 1 drochloride for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC. | ||||
| GC74139 | AZD9496 deacrylic acid phenol | 2173404-70-9 | >96.00% | |
AZD9496 deacrylic acid phenol is a fragment of target protein ligand of PROTAC ER Degrader-4. | ||||
| GC79788 | BTA-1_b | 95856-73-8 | >98.00% | |
BTA-1 _b (BTA-1-CH3) is a structural analog of BTA-1. | ||||
| GC80878 | RIPK2 ligand 3 | 2027561-86-8 | >99.00% | |
RIPK2 ligand 3 is a RIPK2 ligand and can be used for the synthesis of PROTACs, such as PROTAC RIPK degrader-2 [1] . | ||||
| GC80925 | KAT2A/B ligand 1 | 2254066-18-5 | >99.00% | |
KAT2A/B ligand 1 (compound 32a) is a KAT2A/B ligand. | ||||
| GC80926 | BI-7273 acid | 2097514-90-2 | >98.00% | |
BI-7273 acid, BI-7273 derivative, is a BRD9 PROTAC ligand. | ||||
| GC80927 | NSD2 ligand 2 | 3031353-62-2 | >98.50% | |
NSD2 ligand 2 is a ligand for target protein for PROTAC that specifically binds to NSD2. | ||||
| GC80942 | IRF4 ligand-1 | 3113827-15-6 | >99.00% | |
IRF4 ligand-1 is an IRF4 ligand that can be used for the synthesis of PROTACs, such as dIRF4-2 [1] . | ||||
| GC80947 | JAK1/2 ligand 1 | 1026028-96-5 | >99.50% | |
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1. | ||||
| GC81020 | JNK1 ligand-1-NH-Ph-COOH | 3047792-63-9 | >98.00% | |
JNK1 ligand-1 (Compound P1) is a selective JNK1 inhibitor. | ||||
| GC81021 | p38α ligand-1 | 586379-64-8 | >98.50% | |
P38α ligand-1 is a p38α ligand that can be used for the synthesis of PROTACs, such as NR-7h [1] . | ||||
| GC81023 | 5-Iodo-BIIB021 | 911397-54-1 | >98.00% | |
5-Iodo-BIIB021 is a HSP90 ligand. | ||||
| GC81042 | PI3K/mTOR ligand-1 | 1197160-66-9 | >97.00% | |
PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC ( PI3K / mTOR ). | ||||
| GC81299 | c-Met ligand-1 | 1103506-79-1 | >98% | |
c-Met ligand-1 is a c-Met ligand and component of c-Met PROTAC degrader [1] . | ||||
| GC81458 | TT-012-Br | - | >96.00% | |
TT-012-Br (Compound 4) is a ligand for MITF and can be used for the synthesis of PROTACs, such as WZS0347 [1] . | ||||
| GC81513 | SMARCA2/4-ligand-8 | 2380272-41-1 | >99.50% | |
SMARCA2/4-ligand-8 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4-degrader-26 [1] . | ||||