Cathepsin

Ac-VLPE-FMK is a tetrapeptide-based monofluoromethyl ketone (m-FMK) and an inhibitor of Cat-B and Cat-L. It can be used in cancer invasion research.

Cathepsin X-IN-1 (compound 25) is an effective inhibitor of tissue protease X, with an IC50 of 7.13 μM. Cathepsin X-IN-1 reduces PC-3 cell migration and has low cytotoxicity.

N-Ethylmaleimide-d5 is the deuterated form of N-Ethylmaleimide. N-Ethylmaleimide (NEM) is a reagent that alkylates free sulfhydryl groups and is a cysteine protease inhibitor. NEM specifically inhibits phosphate transport in mitochondria. It also acts as an inhibitor of deubiquitinating enzymes.

p-Aminophenylmercuric acetate, an organomercurial MMP activator capable of attacking protein sulfhydryl groups or inducing cysteine switch reactions involved in both the activation and inhibition of MMP-8.

RO5461111 is a highly specific and orally effective Cathepsin S inhibitor (IC50: 0.4 nM, human Cathepsin S; 0.5 nM, murine Cathepsin S). It can effectively inhibit antigen-specific T cell and B cell activation. RO5461111 has an improvement effect on pulmonary inflammation and lupus nephritis.

GB111-NH2 hydrochloride is a cysteine cathepsin inhibitor, and can be used for cancer study.

Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B.

Z-FF-FMK is a selective cathepsin-L inhibitor.

Cathepsin K inhibitor 6 (compound 19) is an inhibitor of cathepsin K (Cat K) with an IC50 of 17 nM.

Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range.

Z-Phe-Arg-pNA is a substrate of Cathepsin L.

Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain.

LN5P45 is an OTUB2 inhibitor (IC50: 2.3 μM).

Olgotrelvir sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L).

Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L.

TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM.

Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC.

NOTA -FZCD-3 is a NOTA -labeled FZCD-3 polypeptide precursor that targets cathepsin D ( CTSD ) with a K D of 0.65 μM.

Anti-hepatic fibrosis agent 3 is an orally active anti-hepatic fibrosis compound targeting Cathepsin D.

Z-Arg-Lys-AOMK is a cathepsin B inhibitor that can cross the blood-brain barrier.

S2160 hydrochloride is a substrate of Cathepsin B that can be utilized in the calorimetric assay for the measurement of cathepsin B [1] .

Cathepsin L-IN-3 (Compound cat L inh.

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate is a Cathepsin D substrate, that can be used for cathepsin D FRET assay [1] .