Cathepsin

L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively.

Petesicatib is a cathepsin S inhibitor, used in research of immune diseases.

VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.

Papain (≥800u/mg)is a cysteine endopeptidase with strong proteolytic activity against a broad range of protein substrates.

Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a Ki of <20 nM.

N-Ethylmaleimide (NEM) is derived from maleic acid and can alkylate free sulfhydryl groups. It is a protein sulfhydryl modifier that can be used to modify cysteine residues in proteins and peptides. N-Ethylmaleimid inhibits prolyl endopeptidase with an IC 50 value of 6.3 μM.

NSC 185058 is a synthetic inhibitor of the ATG4B, with an IC 50 value of 51μM.

3-Epiursolic Acid is a triterpenoid that can be isolated from Myrtaceae, acts as a competitive inhibitor of cathepsin L (IC50, 6.5 μM; Ki, 19.5 μM), with no obvious effect on cathepsin B.

LHVS is a potent, non-selective, irreversible, and cell-permeable cysteine protease and cathepsin inhibitor. LHVS also inhibits T. gondii invasion (IC₅₀=10μM).

Calpain Inhibitor II (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases.

Asperphenamate is a fungal secondary metabolite originally isolated from A.

An amide with diverse biological activities

A cysteine protease inhibitor

JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity.

ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.

SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM.

Cysteine protease inhibitor-2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor-2 inhibits the cells growth of DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μM, respectively.

GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC).

Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D.

Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with Ki values of 41 pM, 68 pM, and 53 pM, respectively.

KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 ?M) against various human cell lines.

S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 ?M. S130 suppresses autophagy flux.

LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5??M and a Kd of 16??M. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo.

Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 μM, >5 μM, >5 μM, >5 μM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity.