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Home >> Signaling Pathways >> Proteases >> Cathepsin

Cathepsin

Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.

Products for  Cathepsin

  1. Cat.No. Product Name Information
  2. GC11553 2-cyano-Pyrimidine cathepsin K inhibitor 2-cyano-Pyrimidine Chemical Structure
  3. GC35111 3-Epiursolic Acid 3-Epiursolic Acid is a triterpenoid that can be isolated from Myrtaceae, acts as a competitive inhibitor of cathepsin L (IC50, 6.5 μM; Ki, 19.5 μM), with no obvious effect on cathepsin B. 3-Epiursolic Acid Chemical Structure
  4. GC46885 Asperglaucide An amide with diverse biological activities Asperglaucide Chemical Structure
  5. GC40769 Asperphenamate Asperphenamate is a fungal secondary metabolite originally isolated from A. Asperphenamate Chemical Structure
  6. GC12751 Balicatib Cathepsin K inhibitor Balicatib Chemical Structure
  7. GC16317 CA 074 A selective cathepsin B inhibitor CA 074 Chemical Structure
  8. GC15917 CA-074 Me A cathepsin B and L inhibitor CA-074 Me Chemical Structure
  9. GC40694 Calpain Inhibitor II Calpain Inhibitor II (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. Calpain Inhibitor II Chemical Structure
  10. GC10342 Calpeptin A calpain inhibitor Calpeptin Chemical Structure
  11. GC65998 Cathepsin C-IN-5 Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 μM, >5 μM, >5 μM, >5 μM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity. Cathepsin C-IN-5 Chemical Structure
  12. GC62889 Cathepsin D and E FRET Substrate acetate Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D. Cathepsin D and E FRET Substrate acetate Chemical Structure
  13. GC10376 Cathepsin G Inhibitor I Cathepsin G Inhibitor I Chemical Structure
  14. GC16181 Cathepsin Inhibitor 1

    Cathepsin inhibitor

     Cathepsin Inhibitor 1 Chemical Structure
  15. GC33892 Cathepsin Inhibitor 2 Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a Ki of <20 nM. Cathepsin Inhibitor 2 Chemical Structure
  16. GC14903 Cathepsin S inhibitor A potent cathepsin S inhibitor Cathepsin S inhibitor Chemical Structure
  17. GC19520 Cysteine Protease inhibitor Cysteine Protease inhibitor is an inhibitor of cysteine protease. Cysteine Protease inhibitor Chemical Structure
  18. GC15708 Cysteine Protease inhibitor hydrochloride

    inhibitor of cysteine protease

     Cysteine Protease inhibitor hydrochloride Chemical Structure
  19. GC62302 Cysteine protease inhibitor-2 Cysteine protease inhibitor-2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor-2 inhibits the cells growth of DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μM, respectively. Cysteine protease inhibitor-2 Chemical Structure
  20. GC13787 E 64d

    A protease inhibitor

     E 64d Chemical Structure
  21. GC13418 E-64 A fungal metabolite with diverse biological activities E-64 Chemical Structure
  22. GC16505 E-64-c An active metabolite of E-64d E-64-c Chemical Structure
  23. GC68008 GÜ2602 GÜ2602 Chemical Structure
  24. GC62634 GSK-2793660 GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 Chemical Structure
  25. GC60960 JPM-OEt JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity. JPM-OEt Chemical Structure
  26. GC60212 K777 A cysteine protease inhibitor K777 Chemical Structure
  27. GC65153 KGP94 KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 ?M) against various human cell lines. KGP94 Chemical Structure
  28. GC17989 L 006235 An inibitor of cathepsin K L 006235 Chemical Structure
  29. GC31465 L-873724 L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 Chemical Structure
  30. GC10027 Leupeptin, Microbial A reversible protease inhibitor Leupeptin, Microbial Chemical Structure
  31. GC38809 LHVS LHVS is a potent, non-selective, irreversible, cell-permeable cysteine protease and cathepsin inhibitor. LHVS Chemical Structure
  32. GC65432 LV-320 LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5??M and a Kd of 16??M. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 Chemical Structure
  33. GA23177 Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂ Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂ is a fluorogenic substrate for cathepsins D and E and not for B, H or L. Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂ Chemical Structure
  34. GC11640 MDL 28170 A cell permeable, selective calpain inhibitor MDL 28170 Chemical Structure
  35. GC34682 N-Ethylmaleimide

    A cysteine protease inhibitor

     N-Ethylmaleimide Chemical Structure
  36. GC69551 N-Ethylmaleimide-d5

    N-Ethylmaleimide-d5 is the deuterated form of N-Ethylmaleimide. N-Ethylmaleimide (NEM) is a reagent that alkylates free sulfhydryl groups and is a cysteine protease inhibitor. NEM specifically inhibits phosphate transport in mitochondria. It also acts as an inhibitor of deubiquitinating enzymes.

     N-Ethylmaleimide-d5 Chemical Structure
  37. GC34924 NSC 185058 An inhibitor of ATG4B NSC 185058 Chemical Structure
  38. GC16388 Odanacatib (MK-0822) Odanacatib (MK-0822) (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC50 of 0.2 nM for human cathepsin K. Odanacatib (MK-0822) Chemical Structure
  39. GC61158 ONO-5334 ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO-5334 Chemical Structure
  40. GC69651 p-Aminophenylmercuric acetate

    p-Aminophenylmercuric acetate is an organic mercury-based matrix metalloproteinase (MMP) activator. It activates and inhibits MMP-8 by attacking protein thiol groups or inducing cysteine conversion reactions. p-Aminophenylmercuric acetate promotes the shedding of pro-BTC, a precursor to beta-fibrinogen. It also affects the binding of opioid receptors with their agonists and antagonists.

     p-Aminophenylmercuric acetate Chemical Structure
  41. GC33829 Papain

    Papain is a cysteine protease with wide specificity, cleaving peptide bonds of basic amino acids, leucine, or glycine.

     Papain Chemical Structure
  42. GC31856 Petesicatib Petesicatib is a cathepsin S inhibitor, used in research of immune diseases. Petesicatib Chemical Structure
  43. GC10477 PMSF

    A nonspecific, irreversible serine protease inhibitor

     PMSF Chemical Structure
  44. GC63856 Relacatib Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib Chemical Structure
  45. GC69824 RO5461111

    RO5461111 is a highly specific and orally effective Cathepsin S inhibitor (IC50: 0.4 nM, human Cathepsin S; 0.5 nM, murine Cathepsin S). It can effectively inhibit antigen-specific T cell and B cell activation. RO5461111 has an improvement effect on pulmonary inflammation and lupus nephritis.

     RO5461111 Chemical Structure
  46. GC65307 S130 S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 ?M. S130 suppresses autophagy flux. S130 Chemical Structure
  47. GC10377 SID 26681509 SID 26681509 Chemical Structure
  48. GC61791 SID 26681509 quarterhydrate SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate Chemical Structure
  49. GC32873 VBY-825 VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V. VBY-825 Chemical Structure
  50. GA23863 Z-Leu-Val-Gly-diazomethylketone Z-Leu-Val-Gly-diazomethylketone is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-Leu-Val-Gly-diazomethylketone Chemical Structure

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