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Home >> Signaling Pathways >> Proteases >> Cathepsin

Cathepsin

Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.

Products for  Cathepsin

  1. Cat.No. Product Name Information
  2. GC11553 2-cyano-Pyrimidine cathepsin K inhibitor 2-cyano-Pyrimidine Chemical Structure
  3. GC35111 3-Epiursolic Acid

    3-Epiursolic Acid, α-Ursolic Acid

     3-Epiursolic Acid is a triterpenoid that can be isolated from Myrtaceae, acts as a competitive inhibitor of cathepsin L (IC50, 6.5 μM; Ki, 19.5 μM), with no obvious effect on cathepsin B. 3-Epiursolic Acid Chemical Structure
  4. GC79583 Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate is a Cathepsin D substrate, that can be used for cathepsin D FRET assay [1]. Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 acetate Chemical Structure
  5. GC68620 Ac-VLPE-FMK

    Ac-Val-Leu-Pro-Glu(OMe)-CH2F

    Ac-VLPE-FMK is a tetrapeptide-based monofluoromethyl ketone (m-FMK) and an inhibitor of Cat-B and Cat-L. It can be used in cancer invasion research.

     Ac-VLPE-FMK Chemical Structure
  6. GC74379 Arg-Arg-AMC acetate Arg-Arg-AMC acetate is the acetate salt form of Arg-Arg-AMC. Arg-Arg-AMC acetate Chemical Structure
  7. GC46885 Asperglaucide

    Aurantiamide Acetate

     An amide with diverse biological activities Asperglaucide Chemical Structure
  8. GC40769 Asperphenamate

    Anabellamide, Auranamide, NSC 306231

     Asperphenamate is a fungal secondary metabolite originally isolated from A. Asperphenamate Chemical Structure
  9. GC12751 Balicatib

    AAE581

     Cathepsin K inhibitor Balicatib Chemical Structure
  10. GC16317 CA 074

    CA-074,CA074

     CA 074 is a selective inhibitor of cathepsin B with a Ki value of 2-5 nM. CA 074 is 10000-30000 times more potent against purified rat cathepsin B than against cathepsin H and L. CA 074 Chemical Structure
  11. GC15917 CA-074 Me

    CA-074Me

     CA-074 Me (CA-074 methyl ester) is a specific inhibitor of Cathepsin B(CB). CA-074 Me Chemical Structure
  12. GC40694 Calpain Inhibitor II

    AcLeuLeuMetH, ALLM

     Calpain Inhibitor II (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. Calpain Inhibitor II Chemical Structure
  13. GC10342 Calpeptin Calpeptin is a reversible and cell-permeable cysteine cathepsin inhibitor. The ID50 values of Calpeptin for calpain I and II (porcine), papain, and platelet calpain I are 52nM, 34nM, 138nM, and 20nM, respectively. Calpeptin alleviates apoptosis and secondary inflammatory changes in muscle cells. Calpeptin Chemical Structure
  14. GC65998 Cathepsin C-IN-5 Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 μM, >5 μM, >5 μM, >5 μM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity. Cathepsin C-IN-5 Chemical Structure
  15. GC62889 Cathepsin D and E FRET Substrate acetate Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D. Cathepsin D and E FRET Substrate acetate Chemical Structure
  16. GC79579 Cathepsin D degrader 1 Anti-hepatic fibrosis agent 3 is an orally active anti-hepatic fibrosis compound targeting Cathepsin D. Cathepsin D degrader 1 Chemical Structure
  17. GC10376 Cathepsin G Inhibitor I Cathepsin G Inhibitor I Chemical Structure
  18. GC16181 Cathepsin Inhibitor 1

    Cathepsin inhibitor

     Cathepsin Inhibitor 1 Chemical Structure
  19. GC33892 Cathepsin Inhibitor 2 Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a Ki of <20 nM. Cathepsin Inhibitor 2 Chemical Structure
  20. GC71006 Cathepsin K inhibitor 6 Cathepsin K inhibitor 6 (compound 19) is an inhibitor of cathepsin K (Cat K) with an IC50 of 17 nM. Cathepsin K inhibitor 6 Chemical Structure
  21. GC79582 Cathepsin L-IN-3 TFA Cathepsin L-IN-3 (Compound cat L inh. Cathepsin L-IN-3 TFA Chemical Structure
  22. GC14903 Cathepsin S inhibitor

    LY 3000328

     A potent cathepsin S inhibitor Cathepsin S inhibitor Chemical Structure
  23. GC68836 Cathepsin X-IN-1

    Cathepsin X-IN-1 (compound 25) is an effective inhibitor of tissue protease X, with an IC50 of 7.13 μM. Cathepsin X-IN-1 reduces PC-3 cell migration and has low cytotoxicity.

     Cathepsin X-IN-1 Chemical Structure
  24. GC19520 Cysteine Protease inhibitor

    2-Pyrimidinecarbonitrile, 4-[[4'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-

     Cysteine Protease inhibitor is an inhibitor of cysteine protease. Cysteine Protease inhibitor Chemical Structure
  25. GC15708 Cysteine Protease inhibitor hydrochloride

    inhibitor of cysteine protease

     Cysteine Protease inhibitor hydrochloride Chemical Structure
  26. GC62302 Cysteine protease inhibitor-2 Cysteine protease inhibitor-2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor-2 inhibits the cells growth of DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μM, respectively. Cysteine protease inhibitor-2 Chemical Structure
  27. GC13787 E 64d

    Aloxistatin, E64c ethyl ester, EP 453, EST, Loxistatin, NSC 694281

     E 64d is a cell-permeable, irreversible, broad-spectrum cysteine protease inhibitor with platelet aggregation inhibitory activity. E 64d Chemical Structure
  28. GC13418 E-64 E-64 is a potent and irreversible inhibitor of cysteine proteases with an IC50 of 9nM for papain. E-64 Chemical Structure
  29. GC16505 E-64-c

    Loxistatin Acid, NSC 694279

     An active metabolite of E-64d E-64-c Chemical Structure
  30. GC68008 GÜ2602 GÜ2602 Chemical Structure
  31. GC70404 GB111-NH2 hydrochloride GB111-NH2 hydrochloride is a cysteine cathepsin inhibitor, and can be used for cancer study. GB111-NH2 hydrochloride Chemical Structure
  32. GC62634 GSK-2793660 GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 Chemical Structure
  33. GC60960 JPM-OEt JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity. JPM-OEt Chemical Structure
  34. GC60212 K777

    APC-3316, CRA-3316, K11777, MePip-Phe-hPhe-VSφ

    A cysteine protease inhibitor

     K777 Chemical Structure
  35. GC65153 KGP94 KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 ?M) against various human cell lines. KGP94 Chemical Structure
  36. GC17989 L 006235

    L-235

     An inibitor of cathepsin K L 006235 Chemical Structure
  37. GC31465 L-873724 L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 Chemical Structure
  38. GC10027 Leupeptin, Microbial

    Acetyl-L-leucyl-L-leucyl-L-argininal

     Leupeptin, Microbial is broad-spectrum, membrane-permeable protease inhibitor that decreases protein degradation. Leupeptin, Microbial Chemical Structure
  39. GC38809 LHVS LHVS is a potent, non-selective, irreversible, and cell-permeable cysteine protease and cathepsin inhibitor. LHVS also inhibits T. gondii invasion (IC₅₀=10μM). LHVS Chemical Structure
  40. GC73242 LN5P45 LN5P45 is an OTUB2 inhibitor (IC50: 2.3 μM). LN5P45 Chemical Structure
  41. GC65432 LV-320 LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5??M and a Kd of 16??M. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 Chemical Structure
  42. GA23177 Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂ Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂ is a fluorogenic substrate for cathepsins D and E and not for B, H or L. Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂ Chemical Structure
  43. GC11640 MDL 28170

    MDL 28170

     MDL 28170, a cell permeable, reversible, peptidic aldehyde inhibitor of calpain (Ki= 0.01µM; Ki for cathepsin B = 0.025µM). MDL 28170 Chemical Structure
  44. GC34682 N-Ethylmaleimide

    NEM

     N-Ethylmaleimide (NEM) is derived from maleic acid and can alkylate free sulfhydryl groups. It is a protein sulfhydryl modifier that can be used to modify cysteine residues in proteins and peptides. N-Ethylmaleimid inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide Chemical Structure
  45. GC69551 N-Ethylmaleimide-d5

    NEM-d5

    N-Ethylmaleimide-d5 is the deuterated form of N-Ethylmaleimide. N-Ethylmaleimide (NEM) is a reagent that alkylates free sulfhydryl groups and is a cysteine protease inhibitor. NEM specifically inhibits phosphate transport in mitochondria. It also acts as an inhibitor of deubiquitinating enzymes.

     N-Ethylmaleimide-d5 Chemical Structure
  46. GC79565 NOTA-FZCD-3 NOTA -FZCD-3 is a NOTA -labeled FZCD-3 polypeptide precursor that targets cathepsin D ( CTSD ) with a K D of 0.65 μM. NOTA-FZCD-3 Chemical Structure
  47. GC34924 NSC 185058 NSC 185058 is a synthetic inhibitor of the ATG4B, with an IC50 value of 51μM. NSC 185058 Chemical Structure
  48. GC16388 Odanacatib (MK-0822)

    MK-0822

     Odanacatib (MK-0822) is an orally active inhibitor of cathepsin K. Odanacatib (MK-0822) Chemical Structure
  49. GC73677 Olgotrelvir sodium

    STI-1558 sodium

     Olgotrelvir sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir sodium Chemical Structure
  50. GC61158 ONO-5334 ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO-5334 Chemical Structure
  51. GC69651 p-Aminophenylmercuric acetate

    APMA

     p-Aminophenylmercuric acetate, an organomercurial MMP activator capable of attacking protein sulfhydryl groups or inducing cysteine switch reactions involved in both the activation and inhibition of MMP-8. p-Aminophenylmercuric acetate Chemical Structure
  52. GC33829 Papain (≥800u/mg) Papain (≥800u/mg)is a cysteine endopeptidase with strong proteolytic activity against a broad range of protein substrates. Papain (≥800u/mg) Chemical Structure
  53. GC31856 Petesicatib Petesicatib is a cathepsin S inhibitor, used in research of immune diseases. Petesicatib Chemical Structure
  54. GC10477 PMSF

    Benzylsulfonyl fluoride, NSC 88499, PMSF

     PMSF is an irreversible serine protease inhibitor that is often added to the lysis buffer before cell or tissue lysis to prevent protein degradation. PMSF Chemical Structure
  55. GC63856 Relacatib

    SB-462795

     Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib Chemical Structure
  56. GC69824 RO5461111

    RO5461111 is a highly specific and orally effective Cathepsin S inhibitor (IC50: 0.4 nM, human Cathepsin S; 0.5 nM, murine Cathepsin S). It can effectively inhibit antigen-specific T cell and B cell activation. RO5461111 has an improvement effect on pulmonary inflammation and lupus nephritis.

     RO5461111 Chemical Structure
  57. GC65307 S130 S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 ?M. S130 suppresses autophagy flux. S130 Chemical Structure
  58. GC79581 S2160 hydrochloride

    Bz-Phe-Val-Arg-pNA hydrochloride

     S2160 hydrochloride is a substrate of Cathepsin B that can be utilized in the calorimetric assay for the measurement of cathepsin B [1]. S2160 hydrochloride Chemical Structure
  59. GC10377 SID 26681509 SID 26681509 Chemical Structure
  60. GC61791 SID 26681509 quarterhydrate SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 quarterhydrate Chemical Structure
  61. GC74001 TS-24 TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 Chemical Structure
  62. GC32873 VBY-825 VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V. VBY-825 Chemical Structure
  63. GC73810 Z-Arg-Arg-βNA acetate Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate Chemical Structure
  64. GA23711 Z-Arg-Arg-AMC Z-Arg-Arg-AMC is a specific substrate for histone B with an Ex/Em of 360/460nm. Z-Arg-Arg-AMC Chemical Structure
  65. GC70709 Z-Arg-Arg-AMC hydrochloride Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B. Z-Arg-Arg-AMC hydrochloride Chemical Structure
  66. GC79580 Z-Arg-Lys-AOMK Z-Arg-Lys-AOMK is a cathepsin B inhibitor that can cross the blood-brain barrier. Z-Arg-Lys-AOMK Chemical Structure
  67. GC70845 Z-FF-FMK Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK Chemical Structure
  68. GC72712 Z-FG-NHO-BzOME Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain. Z-FG-NHO-BzOME Chemical Structure
  69. GA23847 Z-Leu-Arg-AMC Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (AMC) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC Chemical Structure
  70. GA23863 Z-Leu-Val-Gly-diazomethylketone Z-Leu-Val-Gly-diazomethylketone is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-Leu-Val-Gly-diazomethylketone Chemical Structure
  71. GC71347 Z-Nle-Lys-Arg-AMC acetate Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range. Z-Nle-Lys-Arg-AMC acetate Chemical Structure
  72. GA23894 Z-Phe-Arg-AMC . HCl Z-Phe-Arg-AMC . HCl is a substrate for serine proteases, including cathepsins, kallikrein and plasmin. Z-Phe-Arg-AMC . HCl Chemical Structure
  73. GC72234 Z-Phe-Arg-pNA Z-Phe-Arg-pNA is a substrate of Cathepsin L. Z-Phe-Arg-pNA Chemical Structure
  74. GC20162 γ-poly(L-glutamic acid) macromolecule (MW 700000)

    PGA; γ-PGA; Gamma-Polyglutamic acid

     γ-poly(L-glutamic acid) macromolecule (MW 700000) is a high-molecular-weight biopolymer produced by microbial fermentation, characterized by water solubility and biodegradability. γ-poly(L-glutamic acid) macromolecule (MW 700000) Chemical Structure

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