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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC49894 structure
    GC4989415(S)-HETE-d8 ethyl ester
    Purity: >99.00%

    An internal standard for the quantification of 15(S)-HETE ethyl ester

  • GC52105 structure
    GC52105Montelukast
    CAS: 158966-92-8
    Purity: >99.00%

    Montelukast (MK0476 free base) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1).

  • GC52413 structure
    GC524135-Aminosalicylic Acid-d7
    Purity: >99.00%

    An internal standard for the quantification of 5-aminosalicylic acid

  • GC61180 structure
    GC61180Phenidone
    CAS: 92-43-3
    Purity: >98.00%

    Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis.

  • GC62040 structure
    GC62040Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
    CAS: 132465-11-3
    Purity: >99.50%

    Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-Lipoxygenases (LO) inhibitor.

  • GC64078 structure
    GC640783-O-Acetyl-11-hydroxy-beta-boswellic acid
    CAS: 146019-25-2
    Purity: >98.00%

    3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor.

  • GC64621 structure
    GC646214-Nitrocatechol
    CAS: 3316-09-4
    Purity: >98%

    4-Nitrocatechol is a potent lipoxygenase inhibitor.

  • GC66031 structure
    GC660315-LOX-IN-1
    CAS: 55040-82-9
    Purity: >98.00%

    5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation.

  • GC68641 structure
    GC68641ALOX15-IN-1
    Purity: >98.00%

    ALOX15-IN-1 (compound 8b) is an effective and selective inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, with IC50 values of 0.04 μM for ALOX15 homologous substrate linoleic acid (LA) and 2.06 μM for arachidonic acid (AA).

  • GC69335 structure
    GC69335KKII5
    CAS: 6381-55-1
    Purity: >98.00%

    KKII5 is an effective lipoxygenase LOX-1 inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation.

  • GC69434 structure
    GC69434Masoprocol
    CAS: 27686-84-6
    Purity: >99.00%

    Masoprocol (meso-Nordihydroguaiaretic acid) is an effective and orally active inhibitor of lipoxygenase. Masoprocol has shown anti-hyperglycemic activity by reducing glucose levels and liver triglyceride concentrations in the body. It has potential for researching type II diabetes.

  • GC70263 structure
    GC70263Tebufelone
    CAS: 112018-00-5
    Purity: >99.00%

    Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor.

  • GC70448 structure
    GC70448MLS000545091
    CAS: 322666-76-2
    Purity: >99.00%

    MLS000545091 is a potent and selective lipoxygenase-2 (LOX-2) inhibitor with an IC50 value of 2.6 μM for h15-LOX-2.

  • GC72794 structure
    GC72794Flobufen
    CAS: 112344-52-2

    Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent.

  • GC74159 structure
    GC74159MK-0731
    CAS: 845256-65-7
    Purity: >99.00%

    MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6.

  • GC79706 structure
    GC797065-LOX-IN-9
    CAS: 2668-47-5
    Purity: >98.00%

    5-LOX-IN-9 is a 5-lipoxygenase and cyclooxygenase inhibitor, with an IC 50 of 0.2 pM against guinea pig 5-LOX and an IC 50 of 0.7 pM against bovine COX.

  • GC79757 structure
    GC79757ALOX5 stabilizer-1 TFA
    Purity: >98.00%

    ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase ( ALOX5 ) stabilizer with a K d of 7.26 μM.

  • GC81543 structure
    GC81543GPX4-IN-19
    CAS: 3102894-57-2
    Purity: >99.00%

    GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.

  • GC90533 structure
    GC90533(-)-Pinoresinol
    CAS: 81446-29-9
    Purity: >95.00%

    A lignan with diverse biological activities

  • GC90652 structure
    GC9065212-oxo-9(Z)-Dodecenoic Acid
    CAS: 60485-39-4
    Purity: >95.00%

    A metabolite of linoleic acid and linolenic acid

  • GC91594 structure
    GC91594LYS-006 (hydrochloride)
    CAS: 2619563-79-8
    Purity: >98.00%

    LYS-006 is an inhibitor of leukotriene A4 (LTA4) hydrolase.

  • GC91613 structure
    GC91613FerroLOXIN-1
    CAS: 2773428-48-9
    Purity: >90.00%

    FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.

  • GN10269 structure
    GN10269Wedelolactone
    CAS: 524-12-9
    Purity: >99.50%
  • GN10792 structure
    GN10792Caffeic acid
    CAS: 331-39-5
    Purity: >98.50%

    Caffeic acid is a hydroxycinnamic acid polyphenol compound with antioxidant activity. Caffeic acid is an inhibitor of TRPV1 ion channel and 5-lipoxygenase.