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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC41926 structure
    GC4192615(S)-HETE-biotin
    CAS: 1217461-45-4
    Purity: >95.00%

    15(S)-HETE is a major arachidonic acid metabolite produced by the 15-lipoxygenase pathway.

  • GC41927 structure
    GC4192715(S)-HETrE
    CAS: 92693-02-2
    Purity: >98.00%

    15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid.

  • GC41938 structure
    GC4193815-Lipoxygenase Inhibitor 1
    CAS: 928853-86-5
    Purity: >99.50%

    15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 15-Lipoxygenase Inhibitor 1 has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 15-Lipoxygenase Inhibitor 1 has potential for the research of prostate cancer.

  • GC41940 structure
    GC4194015-OxoEDE
    CAS: 105835-44-7
    Purity: >95.00%

    15-OxoEDE is produced by the oxidation of 15-HEDE.

  • GC41951 structure
    GC4195117(R)-Resolvin D1
    CAS: 528583-91-7
    Purity: >95.00%

    Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.

  • GC41952 structure
    GC4195217(R)-Resolvin D4
    CAS: 528583-89-3
    Purity: >98.00%

    17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 .

  • GC41980 structure
    GC4198018-carboxy dinor Leukotriene B4
    CAS: 102674-12-4
    Purity: >97.00%

    18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4.

  • GC42039 structure
    GC420391-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
    CAS: 154436-51-8
    Purity: >98.00%

    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position.

  • GC42040 structure
    GC420401-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
    CAS: 947381-58-0
    Purity: >98.00%

    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position.

  • GC42041 structure
    GC420411-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
    CAS: 154436-48-3
    Purity: >98.00%

    1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position.

  • GC42042 structure
    GC420421-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
    CAS: 154436-49-4
    Purity: >90.00%

    1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position.

  • GC42082 structure
    GC4208220-carboxy Leukotriene B4
    CAS: 80434-82-8
    Purity: >97.00%

    20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils.

  • GC42479 structure
    GC424795(S)-HETrE
    CAS: 195061-94-0
    Purity: >98.00%

    5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate.

  • GC42619 structure
    GC426198(S)-HETrE
    CAS: 889573-69-7
    Purity: >98.00%

    8(S)-HETrE is a monohydroxy polyunsaturated fatty acid produced by rabbit neutrophil lipoxygenase when dihomo-γ-linolenic acid is used as a substrate.

  • GC42636 structure
    GC426369(S)-HOTrE
    CAS: 89886-42-0
    Purity: >98.00%

    9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid.

  • GC42637 structure
    GC426379(S)-HpOTrE
    CAS: 111004-08-1
    Purity: >98.00%

    9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid.

  • GC42651 structure
    GC426519-oxo-10(E),12(E)-Octadecadienoic Acid
    CAS: 54232-58-5
    Purity: >90.00%

    9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxoODA) is a natural agonist, abundant in tomatoes, that activates PPARα at 10-20 μM.

  • GC42653 structure
    GC426539-OxoOTrE
    CAS: 125559-74-2
    Purity: >95.00%

    9-OxoOTrE is produced by the oxidation of 9-HpOTrE.

  • GC43153 structure
    GC43153CAY10416
    CAS: 443919-96-8
    Purity: >95.00%

    Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer.

  • GC43194 structure
    GC43194CAY10698
    CAS: 684236-01-9
    Purity: >98.00%

    Platelet-type 12-lipoxygenase catalyzes the formation of 12-HpETE from arachidonic acid.

  • GC43453 structure
    GC43453Diflapolin
    CAS: 724453-98-9
    Purity: >99.00%

    Diflapolin is a dual inhibitor of 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH).

  • GC43459 structure
    GC43459Dihydro Montelukast
    CAS: 142147-67-9
    Purity: >98.00%

    Dihydro montelukast is a potential impurity found in commercial montelukast preparations.

  • GC43616 structure
    GC43616EOS (d18:1/32:1/18:2)
    CAS: 1318771-31-1
    Purity: >95.00%

    EOS is a ceramide found in the outer layer of the epidermis in mammals.

  • GC44052 structure
    GC44052Leukotriene B4 dimethyl amide
    CAS: 83024-92-4
    Purity: >97.00%

    LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL.