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Lipoxygenase

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products for  Lipoxygenase

  1. Cat.No. Product Name Information
  2. GC10821 11-keto-β-Boswellic Acid leukotriene synthesis inhibitor via 5-lipoxygenase
  3. GC30277 4',5-Dihydroxyflavone
  4. GC31997 5-Lipoxygenase-In-1
  5. GC31938 A-69412
  6. GC32035 AZD 4407 (ZD 4407)
  7. GC32002 Bunaprolast (U66858)
  8. GN10792 Caffeic acid Extracted from Solidago decurrens,large-fruited Chinese hawthorn;Suitability:Hot water and cold ethanol;Store the product in sealed,cool and dry condition
  9. GC31235 Cirsiliol
  10. GC33905 CMI-392
  11. GC31961 CMI977 (LDP977)
  12. GC31967 COX/5-LO-IN-1
  13. GC31940 Docebenone (AA 861)
  14. GC31801 Enazadrem
  15. GC31947 ICI 211965 (ZM-211965)
  16. GC12661 Indirubin-3'-oxime

    GSK-3β and CDK inhibitor

  17. GC38196 Licofelone
  18. GC31978 Lonapalene (RS4317)
  19. GC33907 LP117
  20. GC30610 LY 178002
  21. GC14751 Malotilate Stimulates hepatocyte regeneration

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