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Home >> Signaling Pathways >> Proteases >> Lipoxygenase

Lipoxygenase

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Targets for  Lipoxygenase

Products for  Lipoxygenase

  1. Cat.No. Product Name Information
  2. GC38000 β-Boswellic acid A pentacyclic triterpene with diverse bioactivities β-Boswellic acid Chemical Structure
  3. GC48738 (±)12-HETE-d8

    (±)12-Hydroxyeicosatetraenoic Acid-d8

     (±)12-HETE-d8 Chemical Structure
  4. GC41649 (±)13-HODE cholesteryl ester (±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. (±)13-HODE cholesteryl ester Chemical Structure
  5. GC48739 (±)15-HETE-d8

    (±)15-Hydroxyeicosatetraenoic Acid-d8

     (±)15-HETE-d8 Chemical Structure
  6. GC40828 (±)5-HETE lactone

    (±)5-Hydroxyeicosatetraenoic Acid lactone

     (±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. (±)5-HETE lactone Chemical Structure
  7. GC41666 (±)9-HODE cholesteryl ester (±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL. (±)9-HODE cholesteryl ester Chemical Structure
  8. GC90533 (-)-Pinoresinol

    A lignan with diverse biological activities

     (-)-Pinoresinol Chemical Structure
  9. GC41770 1,2,3-Trieicosapentaenoyl-rac-glycerol

    EPA-TG, Glycerol Trieicosapentaenoate, TG(20:5/20:5/20:5)

     1,2,3-Trieicosapentaenoyl-rac-glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid, which is an ω-3 fatty acid. 1,2,3-Trieicosapentaenoyl-rac-glycerol Chemical Structure
  10. GC45948 1,2,3-Trilinoelaidoyl-rac-glycerol

    TG(18:2(9E,12E)/18:2(9E,12E)/18:2(9E,12E)), Trilinoelaidin

     A triacylglycerol 1,2,3-Trilinoelaidoyl-rac-glycerol Chemical Structure
  11. GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

    15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine

     1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC Chemical Structure
  12. GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

    15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

     1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE Chemical Structure
  13. GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

    15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11

     An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 Chemical Structure
  14. GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

    15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine

     1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC Chemical Structure
  15. GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

    1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE

     1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE Chemical Structure
  16. GC40971 10(S),17(S)-DiHDHA

    10(S),17(S)-DiHDoHE, PDX, Protectin DX

     Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA Chemical Structure
  17. GC40368 11(R)-HEPE 11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO. 11(R)-HEPE Chemical Structure
  18. GC40445 11(R)-HETE

    11(R)-Hydroxyeicosatetraenoic Acid

     11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. 11(R)-HETE Chemical Structure
  19. GC10821 11-keto-β-Boswellic Acid

    11-oxo-β-Boswellic acid,KBA

     11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production. 11-keto-β-Boswellic Acid Chemical Structure
  20. GC41144 11-trans Leukotriene C4

    11trans LTC4

     11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. 11-trans Leukotriene C4 Chemical Structure
  21. GC41147 11-trans Leukotriene D4

    11trans LTD4

     11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. 11-trans Leukotriene D4 Chemical Structure
  22. GC41149 11-trans Leukotriene E4

    11trans LTE4

     Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 Chemical Structure
  23. GC40447 12(R)-HETE

    12(R)-Hydroxyeicosatetraenoic Acid

     Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid. 12(R)-HETE Chemical Structure
  24. GC40371 12(S)-HEPE 12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. 12(S)-HEPE Chemical Structure
  25. GC40448 12(S)-HETE

    12(S)-Hydroxyeicosatetraenoic Acid

    12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.

     12(S)-HETE Chemical Structure
  26. GC40449 12(S)-HETE MaxSpec® Standard 12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. 12(S)-HETE MaxSpec® Standard Chemical Structure
  27. GC40349 12(S)-HETE-19,20-alkyne

    Click Tag 12(S)-HETE-19,20-alkyne, Click Tag 12(S)-Hydroxyeicosatetraenoic Acid-19,20-alkyne

     12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. 12(S)-HETE-19,20-alkyne Chemical Structure
  28. GC41882 12(S)-HETrE 12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA). 12(S)-HETrE Chemical Structure
  29. GC41095 12(S)-HpEPE

    12(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 12-lipoxygenase on eicosapentaenoic acid.

     12(S)-HpEPE Chemical Structure
  30. GC41122 12(S)-HpETE 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. 12(S)-HpETE Chemical Structure
  31. GC41123 12-epi Leukotriene B4

    12epi LTB4

     Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. 12-epi Leukotriene B4 Chemical Structure
  32. GC46416 12-epi Leukotriene B4-d4

    12epi LTB4d4

     A neuropeptide with diverse biological activities 12-epi Leukotriene B4-d4 Chemical Structure
  33. GC41096 12-oxo Leukotriene B4

    12keto LTB4, 12oxo LTB4

     Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. 12-oxo Leukotriene B4 Chemical Structure
  34. GC46418 12-oxo-13-HOME An oxylipin 12-oxo-13-HOME Chemical Structure
  35. GC90652 12-oxo-9(Z)-Dodecenoic Acid

    A metabolite of linoleic acid and linolenic acid

     12-oxo-9(Z)-Dodecenoic Acid Chemical Structure
  36. GC40372 12-OxoETE

    12KETE

     12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. 12-OxoETE Chemical Structure
  37. GC19462 13(R)-HODE 13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. 13(R)-HODE Chemical Structure
  38. GC19463 13(S)-HODE

    13(S)-HODE

     13(S)-HODE (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. 13(S)-HODE Chemical Structure
  39. GC41220 13(S)-HODE methyl ester 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE) is a 15-lipoxygenase metabolite of linoleic acid produced in endothelial cells, leukocytes, and tumor cells. 13(S)-HODE methyl ester Chemical Structure
  40. GC41896 13(S)-HODE-biotin 13(S)-HODE is the lipoxygenase metabolite of linoleic acid. 13(S)-HODE-biotin Chemical Structure
  41. GC46420 13(S)-HODE-d4 An internal standard for the quantification of 13-HODE 13(S)-HODE-d4 Chemical Structure
  42. GC41897 13(S)-HOTrE 13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid. 13(S)-HOTrE Chemical Structure
  43. GC41898 13(S)-HOTrE(γ) 13(S)-HOTrE(γ) is the 15-LO product of γ-linolenic acid. 13(S)-HOTrE(γ) Chemical Structure
  44. GC19474 13(S)-HpODE 13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,1,2 and by 15-LO in mammals. 13(S)-HpODE Chemical Structure
  45. GC41899 13(S)-HpOTrE

    13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.

     13(S)-HpOTrE Chemical Structure
  46. GC41900 13(S)-HpOTrE(γ) 13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. 13(S)-HpOTrE(γ) Chemical Structure
  47. GC41911 13-epi-12-oxo Phytodienoic Acid

    13epi12oxo PDA

     13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. 13-epi-12-oxo Phytodienoic Acid Chemical Structure
  48. GC46436 13-OxoODE-d3

    13KODEd3

     A neuropeptide with diverse biological activities 13-OxoODE-d3 Chemical Structure
  49. GC41206 14(S)-HDHA

    14(S)-hydroxy Docosahexaenoic Acid, 14(S)-HDoHE

     Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. 14(S)-HDHA Chemical Structure
  50. GC41100 14,15-dehydro Leukotriene B4

    14,15dehydro LTB4

     Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. 14,15-dehydro Leukotriene B4 Chemical Structure
  51. GC41145 14,15-Leukotriene C4

    Eoxin C4, EXC4, 14,15LTC4

     Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. 14,15-Leukotriene C4 Chemical Structure
  52. GC41148 14,15-Leukotriene D4

    Eoxin D4, EXD4, 14,15-LTD4

     14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-Leukotriene D4 Chemical Structure
  53. GC41150 14,15-Leukotriene E4

    Eoxin E4, EXE4, 14,15LTE4

     Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. 14,15-Leukotriene E4 Chemical Structure
  54. GC41415 15(R)-Lipoxin A4

    AT-Lipoxin A4

    Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function.

     15(R)-Lipoxin A4 Chemical Structure
  55. GC40427 15(S)-HEDE 15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE Chemical Structure
  56. GC40373 15(S)-HEPE

    15S-hydroxy-Eicosapentaenoic Acid

     15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO. 15(S)-HEPE Chemical Structure
  57. GC40374 15(S)-HEPE MaxSpec® Standard 15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO. 15(S)-HEPE MaxSpec® Standard Chemical Structure
  58. GC46441 15(S)-HEPE-d5

    15S-Hydroxyeicosapentaenoic Acid-d5

     A neuropeptide with diverse biological activities 15(S)-HEPE-d5 Chemical Structure
  59. GC40451 15(S)-HETE

    15(S)-Hydroxyeicosatetraenoic Acid

     15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. 15(S)-HETE Chemical Structure
  60. GC41925 15(S)-HETE Ethanolamide

    15(S)-HAEA, 15(S)-Hydroxyeicosatetraenoic Acid Ethanolamide

     Arachidonoyl ethanolamide was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC. 15(S)-HETE Ethanolamide Chemical Structure
  61. GC40452 15(S)-HETE MaxSpec® Standard 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. 15(S)-HETE MaxSpec® Standard Chemical Structure
  62. GC40839 15(S)-HETE methyl ester

    15(S)-Hydroxyeicosatetraenoic Acid methyl ester

     15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE, a major arachidonic acid metabolite from the 15-lipoxygenase pathway. 15(S)-HETE methyl ester Chemical Structure
  63. GC41926 15(S)-HETE-biotin

    15(S)-Hydroxyeicosatetraenoic Acid-biotin

     15(S)-HETE is a major arachidonic acid metabolite produced by the 15-lipoxygenase pathway. 15(S)-HETE-biotin Chemical Structure
  64. GC46442 15(S)-HETE-d8

    15(S)-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 15-HETE 15(S)-HETE-d8 Chemical Structure
  65. GC49894 15(S)-HETE-d8 ethyl ester

    15(S)-Hydroxyeicosatetraenoic Acid-d8 ethyl ester

     An internal standard for the quantification of 15(S)-HETE ethyl ester 15(S)-HETE-d8 ethyl ester Chemical Structure
  66. GC41927 15(S)-HETrE 15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. 15(S)-HETrE Chemical Structure
  67. GC41403 15(S)-HpEDE

    15(S)-HpEDE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosadienoic acid.

     15(S)-HpEDE Chemical Structure
  68. GC41101 15(S)-HpEPE

    15(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 15-lipoxygenase on eicosapentaenoic acid.

     15(S)-HpEPE Chemical Structure
  69. GC41124 15(S)-HpETE

    15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid.

     15(S)-HpETE Chemical Structure
  70. GC41938 15-Lipoxygenase Inhibitor 1

    15LO Inhibitor 1

     15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 15-Lipoxygenase Inhibitor 1 has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 15-Lipoxygenase Inhibitor 1 has potential for the research of prostate cancer. 15-Lipoxygenase Inhibitor 1 Chemical Structure
  71. GC41940 15-OxoEDE

    15KEDE

     15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE Chemical Structure
  72. GC40376 15-OxoETE

    15KETE

     15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE. 15-OxoETE Chemical Structure
  73. GC41951 17(R)-Resolvin D1

    Aspirin-triggered Resolvin D1

    Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.

     17(R)-Resolvin D1 Chemical Structure
  74. GC41227 17(R)-Resolvin D1 methyl ester

    AspirintriggeredResolvin D1 methyl ester, ATRvD1 methyl ester, 17epiResolvin D1 methyl ester, 17(R)RvD1 methyl ester

     17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM). 17(R)-Resolvin D1 methyl ester Chemical Structure
  75. GC46457 17(R)-Resolvin D1-d5

    Aspirin-triggered Resolvin D1-d5, 17-epi-Resolvin D1-d5, AT-RvD1-d5, 17(R)-RvD1-d5

     A neuropeptide with diverse biological activities 17(R)-Resolvin D1-d5 Chemical Structure
  76. GC41952 17(R)-Resolvin D4

    4(S),5(R),17(R)-trihydroxy-DHA, 17(R)-RvD4

     17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 . 17(R)-Resolvin D4 Chemical Structure
  77. GC41208 17(S)-HDHA

    17(S)hydroxy Docosahexaenoic Acid, 17(S)HDoHE

     17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain. 17(S)-HDHA Chemical Structure
  78. GC46048 17(S)-HDHA-d5

    17(S)-hydroxy Docosahexaenoic Acid-d5, 17(S)-HDoHE-d5

     A neuropeptide with diverse biological activities 17(S)-HDHA-d5 Chemical Structure
  79. GC49356 17(S)-HDoTE

    17(S)-HDTA, 17(S)-hydroxy Docosatetraenoic Acid

     A metabolite of adrenic acid 17(S)-HDoTE Chemical Structure
  80. GC40975 17(S)-HpDHA

    17(S)hydroperoxy Docosahexaenoic Acid, 17(S)HpDoHE

     17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain. 17(S)-HpDHA Chemical Structure
  81. GC41529 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

    EFOX, 17oxo4(Z),7(Z),10(Z),13(Z),15(E),19(Z)DHA, 17-oxo-DHA

     17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid Chemical Structure
  82. GC41209 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

    EFOX, 17-oxo-DPA, 17oxo7(Z),10(Z),13(Z),15(E),19(Z)DPA

     Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid Chemical Structure
  83. GC41980 18-carboxy dinor Leukotriene B4

    18carboxy dinor LTB4

     18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. 18-carboxy dinor Leukotriene B4 Chemical Structure
  84. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO 2,5-Dihydroxycinnamic Acid phenethyl ester Chemical Structure
  85. GC42082 20-carboxy Leukotriene B4

    20carboxy LTB4

     20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. 20-carboxy Leukotriene B4 Chemical Structure
  86. GC41421 20-hydroxy Leukotriene B4

    20hydroxy LTB4

     20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. 20-hydroxy Leukotriene B4 Chemical Structure
  87. GC49849 3-Aminosalicylic Acid

    3-ASA, NSC 285111

     A salicylic acid derivative 3-Aminosalicylic Acid Chemical Structure
  88. GC49364 3-Hydroxycoumarin

    3-Coumarinol, NSC 74691

     A coumarin with diverse biological activities 3-Hydroxycoumarin Chemical Structure
  89. GC64078 3-O-Acetyl-11-hydroxy-beta-boswellic acid 3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor. 3-O-Acetyl-11-hydroxy-beta-boswellic acid Chemical Structure
  90. GC30277 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. 4',5-Dihydroxyflavone Chemical Structure
  91. GC45931 4(S),11(R)-DiHDoHE A neuropeptide with diverse biological activities 4(S),11(R)-DiHDoHE Chemical Structure
  92. GC64621 4-Nitrocatechol 4-Nitrocatechol is a potent lipoxygenase inhibitor. 4-Nitrocatechol Chemical Structure
  93. GC40459 5(R)-HETE

    5(R)-Hydroxyeicosatetraenoic Acid

     5(R)-HETE is a rare lipoxygenase product of arachidonic acid. 5(R)-HETE Chemical Structure
  94. GC41126 5(S),12(S)-DiHETE 5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid. 5(S),12(S)-DiHETE Chemical Structure
  95. GC41127 5(S),15(S)-DiHETE 5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. 5(S),15(S)-DiHETE Chemical Structure
  96. GC41128 5(S),6(R)-11-trans DiHETE 5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE Chemical Structure
  97. GC41129 5(S),6(R)-DiHETE 5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). 5(S),6(R)-DiHETE Chemical Structure
  98. GC41131 5(S),6(S)-DiHETE 5(S),6(S)-DiHETE is one of the four diastereomeric 5,6-dihydroxy acids produced from the non-enzymatic hydrolysis of LTA4. 5(S),6(S)-DiHETE Chemical Structure
  99. GC40378 5(S)-HEPE 5(S)-HEPE is produced by 5-lipoxygenase catalyzed oxidation of eicosapentaenoic acid (EPA). 5(S)-HEPE Chemical Structure
  100. GC40379 5(S)-HEPE MaxSpec® Standard 5(S)-HEPE is produced by 5-lipoxygenase catalyzed oxidation of eicosapentaenoic acid (EPA). 5(S)-HEPE MaxSpec® Standard Chemical Structure
  101. GC40460 5(S)-HETE

    5(S)-Hydroxyeicosatetraenoic Acid

     5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE Chemical Structure

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