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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC44053 structure
    GC44053Leukotriene B4 Ethanolamide
    CAS: 877459-63-7
    Purity: >97.00%

    The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2.

  • GC44054 structure
    GC44054Leukotriene C4 methyl ester
    CAS: 73958-10-8
    Purity: >97.00%

    Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.

  • GC44055 structure
    GC44055Leukotriene D4 methyl ester
    Purity: >97.00%

    Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.

  • GC44056 structure
    GC44056Leukotriene E4 methyl ester
    Purity: >97.00%

    Leukotriene E4 (LTE4) is produced by the action of a dipeptidase on LTD4 leaving only the cysteinyl group still attached to the fatty acid backbone.

  • GC44138 structure
    GC44138MCTR1
    CAS: 1784701-61-6
    Purity: ≥95%

    Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation.

  • GC44139 structure
    GC44139MCTR2
    CAS: 1784701-62-7
    Purity: >97.00%

    Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation.

  • GC44140 structure
    GC44140MCTR3
    CAS: 1784701-63-8
    Purity: >98.00%

    Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages.

  • GC44212 structure
    GC44212MK-886 (sodium salt)
    CAS: 118427-55-7
    Purity: >99.00%

    Arachidonic acid and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO).

  • GC44295 structure
    GC44295N-acetyl Leukotriene E4
    CAS: 80115-95-3
    Purity: >97.00%

    N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile.

  • GC44415 structure
    GC44415N-methyl Leukotriene C4
    CAS: 131391-65-6
    Purity: >97.00%

    Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.

  • GC44579 structure
    GC44579PCTR1
    CAS: 1810710-59-8
    Purity: >96.00%

    Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid.

  • GC44580 structure
    GC44580PCTR2
    CAS: 1810710-63-4
    Purity: >96.00%

    Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid.

  • GC44581 structure
    GC44581PCTR3
    CAS: 1810710-69-0
    Purity: >96.00%

    Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid.

  • GC44818 structure
    GC44818Resolvin D4
    CAS: 1025684-60-9
    Purity: >95.00%

    Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid.

  • GC44879 structure
    GC44879Sclerotiorin
    CAS: 549-23-5
    Purity: >98.00%

    Sclerotiorin is a natural product isolated primarily from Penicillium species.

  • GC45024 structure
    GC45024tetranor-12(S)-HETE
    CAS: 121842-79-3
    Purity: >98%

    12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway.

  • GC45768 structure
    GC45768Pranlukast-d4
    CAS: 2713172-43-9
    Purity: >99.00%

    A neuropeptide with diverse biological activities

  • GC45931 structure
    GC459314(S),11(R)-DiHDoHE
    Purity: >95.00%

    A neuropeptide with diverse biological activities

  • GC45948 structure
    GC459481,2,3-Trilinoelaidoyl-rac-glycerol
    CAS: 5188-25-0
    Purity: >98.00%

    A triacylglycerol

  • GC45951 structure
    GC45951BLX3887
    CAS: 934758-70-0
    Purity: >95.00%

    A 15-LO-1 inhibitor

  • GC45960 structure
    GC459609c(i472)
    CAS: 2349374-37-2
    Purity: >95.00%

    9c(i472) is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM.

  • GC46048 structure
    GC4604817(S)-HDHA-d5
    CAS: 2738376-87-7
    Purity: >99.00%

    A neuropeptide with diverse biological activities

  • GC46057 structure
    GC460572,5-Dihydroxycinnamic Acid phenethyl ester
    CAS: 179691-97-5
    Purity: >98.00%

    An inhibitor of 5-LO

  • GC46105 structure
    GC46105Butyrolactone II
    CAS: 87414-44-6
    Purity: >95.00%

    A fungal metabolite